Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The protective mechanism of tamoxifen action in the ovary during chemotherapy

2016/21/B/NZ4/00202

Keywords:

tumor chemotherapy fertility preservation tamoxifen the rat transcriptomics proteomics

Descriptors:

  • NZ1_1: Molecular biology
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ4_12: Other related subjects

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Biologii i Biotechnologii

woj. warmińsko-mazurskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Renata Ciereszko 

Number of co-investigators in the project: 6

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 074 770 PLN

Project start date (Y-m-d): 2017-02-01

Project end date (Y-m-d): 2021-01-31

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Gilotyna (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (2)
  1. Molecular action of tamoxifen in the ovaries of rats with mammary neoplasia
    Authors:
    Nynca Anna, Swigonska Sylwia, Molcan Tomasz, Petroff Brian K, Ciereszko Renata E.
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 15767), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  2. Tamoxifen decreases ovarian toxicity without compromising cancer treatment in a rat model of mammary cancer
    Authors:
    Anna Nynca, Sylwia Swigonska, Monika Ruszkowska, Agnieszka Sadowska, Karina Orlowska, Tomasz Molcan, Kamil Myszczynski, Iwona Otrocka‑Domagala, Katarzyna Paździor‑Czapula, Beata Kurowicka, Brian Kelli Petroff and Renata Elzbieta Ciereszko
    Academic press:
    BMC Genomics (rok: 2023, tom: 24, strony: 325 (open access)), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12864-023-09423-0 - link to the publication
  1. The effects of tamoxifen on steroid hormone production in cancer rats receiving cyclophosphamide treatment
    Authors:
    Nynca A., Swigonska S., Ruszkowska M., Sadowska A., Orlowska K., Molcan T., Ciereszko R. E.
    Conference:
    Animal Physiology 2019, 15 International Scientific Conference (rok: 2019, ), Wydawca: Slovak University of Agriculture in Nitra
    Data:
    konferencja 2019-05-27-29
    Status:
    Published
  2. The effects of tamoxifen on serum gonadotropin levels in tumor-bearing rats treated with cyclophosphamide
    Authors:
    Ruszkowska M., Nynca A., Sadowska A., Orlowska K., Swigonska S., Ciereszko R.E.
    Conference:
    Animal Physiology 2019, 15 International Scientific Conference (rok: 2019, ), Wydawca: Slovak University of Agriculture in Nitra
    Data:
    konferencja 2019-05-27-29
    Status:
    Published

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