Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Products formed during thermo-oxidative degradation of stigmasterol and its esters - isolation, fractionation and evaluation of their cytotoxicity and mechanisms of action in human normal cells in vitro

2015/17/B/NZ9/01535

Keywords:

phytosterols fatty acids thermo-oxidation degradation cytotoxicity genotoxicity

Descriptors:

  • NZ9_7: Nutrition and food sciences

Panel:

NZ9 - Fundamentals of applied life sciences and biotechnology: agricultural, forestry, horticulture, animal production and fishery, food and nutrition sciences, industrial biosciences, environmental biotechnology and remediation

Host institution :

Uniwersytet Przyrodniczy w Poznaniu, Wydział Nauk o Żywności i Żywieniu

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Magdalena Rudzińska 

Number of co-investigators in the project: 10

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 1 164 900 PLN

Project start date (Y-m-d): 2016-04-27

Project end date (Y-m-d): 2020-02-26

Project duration:: 46 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Autosampler do chromatografu gazowego Trace 1300 (75 000 PLN)
  2. Komputer osobisty typu laptop (2 szt.) (10 000 PLN)
  3. Generator wodoru (33 381 PLN)
  4. Zestaw do elektroforezy i elektrotransferu białek z zasilaczem (10 000 PLN)
  5. Zestaw pipet automatycznych (5 500 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Impact of added phytosteryl/phytostanyl fatty acid esters on chemical parameters of margarines upon heating and pan-frying
    Authors:
    Raczyk M., Bonte A., Matthaus B., Rudzińska M.
    Academic press:
    European Journal of Lipid Science and Technology (rok: 2018, tom: 120, strony: 1700281 (11 stron)), Wydawca: Wiley VCH Verlag GmbH & Co. KGaA Weinheim
    Status:
    Published
    DOI:
    10.1002/ejlt.201700281 - link to the publication
  2. The degradation of bioactive compounds and formation of their oxidation derivatives in refined rapeseed oil during heating in model system
    Authors:
    Kasprzak Maria, Rudzińska Magdalena, Przybylski Roman, Kmiecik Dominik, Siger Aleksander, Olejnik Anna
    Academic press:
    LWT - Food Science and Technology (rok: 2020, tom: 123, strony: 109078), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.lwt.2020.109078 - link to the publication
  3. Anti-proliferative potential and oxidative reactivity of thermo-oxidative degradation products of stigmasterol and stigmasteryl esters for human intestinal cells
    Authors:
    Kasprzak M., Rudzińska M., Juzwa W., Olejnik A.
    Academic press:
    Scientific Reports (rok: 2023, tom: 13, strony: 7093), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-023-34335-0 - link to the publication
  4. Acyl moiety and temperature affects thermo-oxidative degradation of steryl esters. Cytotoxicity of the degradation products.
    Authors:
    Kasprzak Maria, Rudzińska Magdalena, Kmiecik Dominik, Przybylski Roman, Olejnik Anna
    Academic press:
    Food and Chemical Toxicology (rok: 2020, tom: 136, strony: 111074), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.fct.2019.111074 - link to the publication

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