Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Determination of the mechanism of action of polycyclic aromatic hydrocarbons on endocrine and metabolic function of human placenta in co-culture model, reflecting the fetal-placental unit.

2015/19/N/NZ7/01093

Keywords:

placental steroidogenesis polycyclic aromatic hydrocarbons feto-placental unit metabolism

Descriptors:

  • NZ4_6: Endocrinology
  • NZ7_15: Toxicology
  • NZ7_2: Environment and health risks

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński, Wydział Biologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Eliza Drwal 

Number of co-investigators in the project: 2

Call: PRELUDIUM 10 - announced on 2015-09-15

Amount awarded: 149 440 PLN

Project start date (Y-m-d): 2016-08-12

Project end date (Y-m-d): 2019-08-11

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zestaw do analizy Western blot (Mini Protean Tetra Cell, PowerPac HC Power Supply, Mini Trans-Blot Cells) (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Review: Polycyclic aromatic hydrocarbons (PAHs)-Action on placental function and health risks in future life of newborns.
    Authors:
    Eliza Drwal, Agnieszka Rak, Ewa Gregoraszczuk
    Academic press:
    Toxicology (rok: 2019, tom: 411, strony: 133-142), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.003 - link to the publication
  2. Co-culture of JEG-3, BeWo and syncBeWo cell lines with adrenal H295R cell line: an alternative model for examining endocrine and metabolic properties of the fetoplacental unit
    Authors:
    Eliza DrwalAgnieszka RakEwa Gregoraszczuk
    Academic press:
    Cytotechnology (rok: 2017, tom: 70, strony: 285–297), Wydawca: Springer Netherlands
    Status:
    Published
    DOI:
    10.1007/s10616-017-0142-z - link to the publication
  3. Differential effects of ambient PAH mixtures on cellular and steroidogenic properties of placental JEG-3 and BeWo cells.
    Authors:
    Drwal E, Rak A, Gregoraszczuk EL
    Academic press:
    Reproductive Toxicology (rok: 2019, tom: 86, strony: 14-22), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.reprotox.2019.03.003 - link to the publication

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