Projects funded by the NCN


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332 projects found matching your search criteria :

  1. Design and synthesis of acylpeptide hydrolase inhibitors as potential inducers of apoptosis in tumor cells

    Call: PRELUDIUM 5 , Panel: ST5

    Principal investigator: Maciej Sławomir Walczak

    Politechnika Wrocławska, Wydział Chemiczny

  2. RNA chaperone activity of HIV-2 Gag and nuclocapsid proteins: implications for the design of the new retroviral inhibito...

    Call: SONATA 1 , Panel: NZ1

    Principal investigator: dr Katarzyna Pachulska-Wieczorek

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  3. Design and synthesis of selective and irreversible inhibitors of HAT protease.

    Call: PRELUDIUM 5 , Panel: ST5

    Principal investigator: Marcin Skoreński

    Politechnika Wrocławska, Wydział Chemiczny

  4. Phosphonic inhibitors of human neutrophil elastase in cancer therapy

    Call: SONATA 5 , Panel: NZ4

    Principal investigator: dr Łukasz Winiarski

    Politechnika Wrocławska, Wydział Chemiczny

  5. Determination of the structural elements responsible for the narrow substrate specificity of staphylococcal proteases Sp...

    Call: PRELUDIUM 1 , Panel: NZ1

    Principal investigator: Michał Waldemar Zdżalik

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  6. Inhibition of activity tryptophan hydroxylase-1 - the new conception in the treatment of mineral and bone disorders in c...

    Call: OPUS 5 , Panel: NZ7

    Principal investigator: prof. Krystyna Pawlak

    Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

  7. New methods for mRNA 5' end labeling and examples of their application in studies on RNA metabolism and searching for in...

    Call: OPUS 5 , Panel: ST5

    Principal investigator: dr hab. Jacek Jemielity

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  8. Inhibitory neurotransmitter GABA in the aging of nervous system

    Call: OPUS 5 , Panel: NZ3

    Principal investigator: dr Monika Barbara Liguz-Lęcznar

    Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

  9. Assessment of mechanisms of tumour necrosis factor alpha (TNF-alpha) inhibitors' action in rheumatoid arthritis female p...

    Call: PRELUDIUM 5 , Panel: NZ5

    Principal investigator: Anna Iwona Szeremeta

    Śląski Uniwersytet Medyczny w Katowicach, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

  10. Morita-Baylis-Hillman adducts as substrates in the synthesis of biologically active organophosphorus compounds

    Call: OPUS 5 , Panel: ST5

    Principal investigator: dr hab. Artur Jacek Mucha

    Politechnika Wrocławska, Wydział Chemiczny

  11. Synthesis and studies of reaction products of oxirane derivatives with the -NH-(C=)-Br functionality of heteroaromatic c...

    Call: PRELUDIUM 1 , Panel: NZ4

    Principal investigator: dr Marzena Agnieszka Baran

    Uniwersytet Jagielloński- Collegium Medicum, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

  12. Extracellular proteolytic activity of human epithelium - role in the modulation of signal transduction.

    Call: SYMFONIA 1 , Panel: NZ1

    Principal investigator: prof. Jan Stanislaw Potempa

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  13. The role of neutral endopeptidase (NEP) and its inhibitor, sialorphin, in colon cancer cells biology.

    Call: OPUS 4 , Panel: NZ3

    Principal investigator: prof. Martyna Maria Kandefer-Szerszeń

    Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

  14. Design, chemical synthesis and enzymatic evaluation of peptidic substrates and inhibitors of cathepsin C

    Call: PRELUDIUM 4 , Panel: ST5

    Principal investigator: dr Monika Katarzyna Łęgowska

    Uniwersytet Gdański, Wydział Chemii

  15. Synthesis and preliminary studies on biological activity of glycosyltransferases natural substrates analogues, derivativ...

    Call: PRELUDIUM 4 , Panel: ST5

    Principal investigator: Roman Marcin Komor

    Politechnika Śląska, Wydział Chemiczny

  16. One-pot synthesis of O-2-isocepham and N-2-isocepham derivatives bearing retroamide/thioretroamide or phosphono/thiophos...

    Call: PRELUDIUM 4 , Panel: NZ7

    Principal investigator: Marta Leokadia Schielmann

    Politechnika Gdańska, Wydział Chemiczny

  17. Theoretical model of SH2-dependent STAT1 dimerization as a novel tool to identify specific compounds of functional inhib...

    Call: PRELUDIUM 4 , Panel: NZ2

    Principal investigator: Małgorzata Szeląg

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

  18. Kinases of emerging relevance in cancer - structural characterization.

    Call: SONATA BIS 2 , Panel: NZ1

    Principal investigator: dr Grzegorz Dubin

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  19. Synthesis and pharmacological properties of mono- di- and triheterocyclic azole derivatives as a hybrid receptor and PDE...

    Call: OPUS 4 , Panel: NZ7

    Principal investigator: prof. Maciej Henryk Pawłowski

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  20. DNA double-stranded break repair proteins as a target for personalized cancer therapy based on synthetic lethality

    Call: OPUS 4 , Panel: NZ7

    Principal investigator: dr hab. Tomasz Śliwiński

    Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

  21. Search of novel multifunctional ligands targeting neurodegereneration processes.

    Call: OPUS 4 , Panel: NZ7

    Principal investigator: prof. Barbara Antonina Malawska

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  22. New chemical and biological properties of topoizomeraze I inhibitors alkylating DNA oligomers

    Call: OPUS 4 , Panel: ST4

    Principal investigator: prof. Lech Jan Kozerski

    Instytut Chemii Organicznej Polskiej Akademii Nauk

  23. Synthesis and analysis of potential furin inhibitors in the development of the new therapeutic strategies against viral ...

    Call: PRELUDIUM 4 , Panel: ST5

    Principal investigator: Monika Aleksandra Lewandowska-Goch

    Uniwersytet Gdański, Wydział Chemii

  24. In vitro/in vivo characteristics of hydrophilic matrix containing phosphodiesterase-5 inhibitors.

    Call: SONATA 4 , Panel: NZ7

    Principal investigator: dr Anna Krupa

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  25. Cardioprotective effect of inhibitors of matrix metalloproteinase-2 (MMP-2) and inhibitors of posttanslational modificat...

    Call: HARMONIA 3 , Panel: NZ3

    Principal investigator: prof. Mieczysław Woźniak

    Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

  26. Effect of deimination of essential arginine residues on the function of protease inhibitors and other components of inna...

    Call: OPUS 3 , Panel: NZ6

    Principal investigator: dr Tomasz Kantyka

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  27. Impact of combined therapy of non-steroidal anti-inflammatory drugs and selective serotonin reuptake inhibitors on oxida...

    Call: OPUS 3 , Panel: NZ5

    Principal investigator: dr hab. Piotr Gałecki

    Uniwersytet Medyczny w Łodzi, Wydział Wojskowo-Lekarski; Klinika Psychiatrii Dorosłych

  28. Structure - activity relationship studies of new flavonoids derivatives as the inhibitors of the bacterial tyrosyl-tRNA ...

    Call: PRELUDIUM 3 , Panel: NZ7

    Principal investigator: dr Mirosława Anna Skupińska

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  29. Stilbene and stilbazole derivatives as potential cyclooxygenase-2 (COX-2) inhibitors with probable antitumor and chemopr...

    Call: PRELUDIUM 1 , Panel: NZ4

    Principal investigator: Miłosz Jakub Regulski

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

  30. Stimulation of endogenous neurogenesis as a novel therapeutic strategy in neonatal hypoxic-ischemic brain injury.

    Call: OPUS 3 , Panel: NZ3

    Principal investigator: dr Małgorzata Nałęcz

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  31. The role of corticotropin releasing factor (CRF) in low and high anxiety rats, and teh iteraction between of the CRF sys...

    Call: OPUS 3 , Panel: NZ7

    Principal investigator: dr Anna Karolina Skórzewska

    Instytut Psychiatrii i Neurologii

  32. Diaminophosphonates as specific inhibitors of Neisseria meningitidis aminopeptidase N - synthesis and biological activit...

    Call: PRELUDIUM 3 , Panel: ST5

    Principal investigator: Ewelina Marta Węglarz-Tomczak

    Politechnika Wrocławska, Wydział Chemiczny

  33. Evaluation of pharmacological activity of new, nonselective gamma-aminobutyric acid (GABA) transport inhibitors in some ...

    Call: OPUS 3 , Panel: NZ7

    Principal investigator: dr hab. Kinga Sałat

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  34. Organometallic inhibitors of tubulin polymerisation. Synthesis, anticancer activities and tubulin affinities.

    Call: OPUS 3 , Panel: ST5

    Principal investigator: dr hab. Damian Plażuk

    Uniwersytet Łódzki, Wydział Chemii

  35. Modifications of aglycones of leucomycins via Michael addition and Huisgen dipolar cycloaddition as a new routes of synt...

    Call: SONATA BIS 1 , Panel: ST5

    Principal investigator: dr hab. Piotr Przybylski

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

  36. Identification of amino acid residues located in positions P7 and P8 of model inhibitor of proprotein convertases that d...

    Call: PRELUDIUM 3 , Panel: ST5

    Principal investigator: Izabela Małuch

    Uniwersytet Gdański, Wydział Chemii

  37. Synthesis of mononucleotide N2,N2,7-trimethylguanosine cap analogues as translation inhibitors in Ascaris suum

    Call: PRELUDIUM 3 , Panel: ST5

    Principal investigator: dr Karolina Ewa Piecyk

    Uniwersytet Warszawski, Wydział Chemii

  38. The influence of metabolic pathway inhibitors on the development and quality of bovine embryos produced in vitro.

    Call: OPUS 3 , Panel: NZ9

    Principal investigator: dr hab. Dorota Marta Cieślak

    Uniwersytet Przyrodniczy w Poznaniu, Wydział Medycyny Weterynaryjnej i Nauk o Zwierzętach

  39. Pattern-Specific Inhibitors (PSI) - introduction and basic characteristics of a new class of inhibitors that block recog...

    Call: OPUS 3 , Panel: NZ6

    Principal investigator: dr Krzysztof Guzik

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  40. Peptide splicing - the mechanism and its application for designing compounds with potential use in medicinal practice

    Call: OPUS 1 , Panel: ST5

    Principal investigator: prof. Krzysztof Rolka

    Uniwersytet Gdański, Wydział Chemii

  41. Research into the understanding of a defense mechanism of wheat (Triticum aestivum) in response to feeding Oulema spp. -...

    Call: OPUS 2 , Panel: NZ9

    Principal investigator: dr hab. Aleksandra Julia Obrępalska-Stęplowska

    Instytut Ochrony Roślin - Państwowy Instytut Badawczy

  42. Solution NMR investigations of human cystatin C - structure, dynamics and protein-ligand interactions.

    Call: PRELUDIUM 2 , Panel: ST4

    Principal investigator: Martyna Ewa Maszota-Zieleniak

    Uniwersytet Gdański, Wydział Chemii

  43. Hydrogen exchange mass spectrometry (HXMS) for studying human serum amyloid A fibril formation.

    Call: PRELUDIUM 2 , Panel: NZ5

    Principal investigator: Marta Sosnowska

    Uniwersytet Gdański, Wydział Chemii

  44. Novel urease inhibitors as means to control ureolytic microbial pathogens

    Call: OPUS 2 , Panel: NZ6

    Principal investigator: dr Agnieszka Grabowiecka

    Politechnika Wrocławska

  45. Novel insights into inhibition of PD-L1/PD-1 immune checkpoint – discovery and optimization of covalent PD-L1 inhibitors...

    Call: SONATA 20 , Panel: ST5

    Principal investigator: dr Radosław Dariusz Kitel

    Uniwersytet Jagielloński

  46. A new feature of the yeast Kazachstania humilis species: Growth-inhibitory properties against a broad spectrum of bacter...

    Call: OPUS 28 , Panel: NZ9

    Principal investigator: dr hab. Anna Sikora

    Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

  47. Environmental modulation of CDK4/6 inhibitor efficacy: Impact of mycotoxin alternariol exposure on anti-cancer therapies

    Call: SONATA 20 , Panel: NZ5

    Principal investigator: dr Anna Dominika Walczak-Szeffer

    Uniwersytet Medyczny w Łodzi

  48. Phytochemicals as inhibitors of polylactide's photooxidation and thermooxidation

    Call: SONATA 20 , Panel: ST11

    Principal investigator: dr Aleksander Mateusz Hejna

    Politechnika Poznańska

  49. Analysis of pharmacokinetic, pharmacodynamic and molecular determinants of intolerance and resistance to the Janus kinas...

    Call: OPUS 27 , Panel: NZ7

    Principal investigator: dr hab. Marta Katarzyna Karaźniewicz-Łada

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  50. Frog skin derived cyclic peptide as a molecular scaffold to create a novel tool for combining visualization and inhibiti...

    Call: PRELUDIUM 23 , Panel: ST5

    Principal investigator: Aleksandra Dorota Helbik-Maciejewska

    Uniwersytet Gdański