Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Histone deacetylase inhibitors as potential modulatory factors of inflammatory response induced in the rat brain after neonatal asphyxia.

2017/27/B/NZ3/00582

Keywords:

HDAC inhibitors Sodium Butyrate Givinostat neonatal asphyxia microglia polarization

Descriptors:

  • NZ3_6: Cell neurobiology
  • NZ3_5: Molecular neurobiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Małgorzata Nałęcz 

Number of co-investigators in the project: 6

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 801 847 PLN

Project start date (Y-m-d): 2018-07-24

Project end date (Y-m-d): 2023-07-23

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Incubator NU-58.41 (52 500 PLN)
  2. Sprzęt komputerowy (8 000 PLN)
  3. Komora laminarna NuAire NU-545 (40 500 PLN)
  4. Waga laboratoryjna (8 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Aberrant Complement System Activation in Neurological Disorders
    Authors:
    Karolina Ziabska, Małgorzata Ziemka-Nalecz , Paulina Pawelec , Joanna Sypecka, Teresa Zalewska
    Academic press:
    International Journal of Molecular Scences (rok: 2021, tom: 22, strony: 4675), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094675 - link to the publication
  2. Effect of the HDAC Inhibitor, Sodium Butyrate, on Neurogenesis in a Rat Model of Neonatal Hypoxia-Ischemia: Potential Mechanism of Action.
    Authors:
    Joanna Jaworska, Teresa Zalewska, Joanna Sypecka, Małgorzata Ziemka-Nałęcz
    Academic press:
    Molecular Neurobiology (rok: 2019, tom: 56 (9), strony: 6341-6370), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-019-1518-1 - link to the publication
  3. Analysis of Givinostat/ITF2357 Treatment in a Rat Model of Neonatal Hypoxic-Ischemic Brain Damage.
    Authors:
    Paulina Pawelec, Joanna Sypecka , Teresa Zalewska, Małgorzata Ziemka-Nalecz
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23(15), strony: 8287), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23158287 - link to the publication
  4. The impact of the histone deacetylase inhibitor sodium butyrate on microglial polarization after oxygen and glucose deprivation
    Authors:
    Karolina Ziąbska , Justyna Gargaś, Joanna Sypecka, Małgorzata Ziemka-Nałęcz
    Academic press:
    Pharmacological Reports (rok: 2022, tom: 74(5), strony: 909-919), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-022-00384-x - link to the publication
  5. Impact of a histone deacetylase inhibitor - Trichostatin A on neurogenesis after hypoxia-ischemia in immature rats.
    Authors:
    Teresa Zalewska, Joanna Jaworska, Joanna Sypecka, Malgorzata Ziemka-Nalecz
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21 (11), strony: 3808), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21113808 - link to the publication
  6. The Impact of the CX3CL1/CX3CR1 Axis in Neurological Disorders
    Authors:
    Paulina Pawelec, Malgorzata Ziemka-Nalecz, Joanna Sypecka, Teresa Zalewska
    Academic press:
    Cells (rok: 2020, tom: 9 (10), strony: 2277), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9102277 - link to the publication
  7. Sexual Dimorphism in Neurodegenerative Diseases and in Brain Ischemia
    Authors:
    Teresa Zalewska, Paulina Pawelec, Karolina Ziąbska , Małgorzata Ziemka-Nałęcz
    Academic press:
    Biomolecules (rok: 2023, tom: 13(1), strony: 26), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom13010026 - link to the publication

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