Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Anticancer activity of novel tubulin polymerization inhibitors obtained by the chemical modification of colchicine

2016/21/B/ST5/00111

Keywords:

anticancer drugs synthesis inhibitors of microtubule polymerization anticancer activity

Descriptors:

  • ST5_16:
  • NZ4_12: Other related subjects
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Adam Huczyński 

Number of co-investigators in the project: 5

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 813 360 PLN

Project start date (Y-m-d): 2017-01-18

Project end date (Y-m-d): 2020-01-17

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Profesjonalny zestaw do chromatografii typu FLASH i preparatywnej HPLC z detektorami UV i ELSD (375 000 PLN)

Information in the final report

  • Publication in academic press/journals (12)
  1. Carbamate derivatives of colchicine show potent activity towards primary acute lymphoblastic leukemia and primary breast cancer cells – in vitro and ex vivo study
    Authors:
    A. Urbaniak, F.Jousheghany, S. Piña-Oviedo, Y. Yuan, U. Majcher-Uchańska, G. Klejborowska, A. Moorjani, B. Monzavi-Karbassi, A. Huczyński ,T.C. Chambers
    Academic press:
    Journal of Biochemical and Molecular Toxicology (rok: 2020, tom: 34(6), strony: e22487), Wydawca: John Wiley & Sons
    Status:
    Published
    DOI:
    10.1002/jbt.22487 - link to the publication
  2. In silico Investigations of the Mode of Action of Novel Colchicine Derivatives Targeting β-Tubulin Isotypes: A Search for a Selective and Specific β-III Tubulin Ligand
    Authors:
    Pallante L., Rocca A., Klejborowska G., Huczynski A., Grasso G., Tuszynski J. A., Deriu M. A.
    Academic press:
    Frontiers in Chemistry (rok: 2020, tom: 8, strony: 108), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fchem.2020.00108 - link to the publication
  3. Synthesis, antiproliferative activity, and molecular docking studies of 4-chlorothiocolchicine analogues
    Authors:
    G. Klejborowska, M. Moshari, E. Maj, U. Majcher, J. Preto, J. Wietrzyk, J.A ,Tuszynski, A. Huczyński*
    Academic press:
    Chemical Biology and Drug Design (rok: 2020, tom: 95(1), strony: 182-191), Wydawca: John Wiley & Sons Ltd.
    Status:
    Published
    DOI:
    10.1111/cbdd.13618 - link to the publication
  4. Synthesis, biological evaluation and molecular docking studies of new amides of 4-bromothiocolchicine as anticancer agents,
    Authors:
    G. Klejborowska, A. Urbaniak, J. Preto, E. Maj, M. Moshari, J. Wietrzyk, J. A. Tuszynski, T.C. Chambers, A. Huczyński*
    Academic press:
    Bioorganic & Medicinal Chemistry (rok: 2019, tom: 27, strony: art. no. 115144), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmc.2019.115144 - link to the publication
  5. Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents
    Authors:
    U. Majcher, G. Klejborowska, M. Kaik, E. Maj, J. Wietrzyk, M. Moshari, J. Preto, J. Tuszynski, A. Huczyński*
    Academic press:
    Cells (rok: 2018, tom: 7, strony: 216), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells7110192 - link to the publication
  6. Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives
    Authors:
    U. Majcher, G. Klejborowska, M. Moshari, E. Maj, J. Wietrzyk, F. Bartl, J.A. Tuszynski, A. Huczyński*
    Academic press:
    Cells (rok: 2018, tom: 7, strony: 192), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells7110192 - link to the publication
  7. Synthesis and antiproliferative screening of novel analogs of regioselectively demethylated colchicine and thiocolchicine
    Authors:
    D. Czerwonka, S. Sobczak, E.Maj, J. Wietrzyk, A.Katrusiak, A. Huczynski*
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 1180), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25051180 - link to the publication
  8. Synthesis, Antiproliferative Activity and Molecular Docking Studies of Novel Doubly Modified Colchicine Amides and Sulfonamides as Anticancer Agents.
    Authors:
    Krzywik, J.; Mozga, W.; Aminpour, M.; Janczak, J.; Maj, E.; Wietrzyk, J.; Tuszyński, J.A.; Huczyński, A.*
    Academic press:
    Moleules (rok: 2020, tom: 25(8), strony: 1789), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25081789 - link to the publication
  9. Synthesis, anticancer activity and molecular docking studies of N-deacetylthiocolchicine and 4-iodo-N-deacetylthiocolchicine derivatives,
    Authors:
    Greta Klejborowska, Alicja Urbaniak, Ewa Maj, Joanna Wietrzyk, Mahshad Moshari, Jordane Preto, Jack A. Tuszynski, Timothy C. Chambers, Adam Huczyński*
    Academic press:
    Bioorganic & Medicinal Chemistry (rok: 2021, tom: 32, strony: 116014), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmc.2021.116014 - link to the publication
  10. Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes
    Authors:
    U. Majcher, A. Urbaniak, E. Maj, M. Moshari, M. Delgado, J. Wietrzyk, F. Bartl, T.C. Chambers, J.A. Tuszynski, A. Huczyński*
    Academic press:
    Bioorganic Chemistry (rok: 2018, tom: 81, strony: 553-566), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2018.09.004 - link to the publication
  11. Synthesis, biological evaluation and molecular docking studies of new amides of 4-chlorothiocolchicine as anticancer agents
    Authors:
    G. Klejborowska, A. Urbaniak, E. Maj, J. Preto, M. Moshari, J. Wietrzyk, J. A. Tuszynski, T. C. Chambers, A. Huczyński*
    Academic press:
    Bioorganic Chemistry (rok: 2020, tom: 97, strony: art. nr 103664), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2020.103664 - link to the publication
  12. Photoinduced Skeletal Rearrangement of N-Substituted Colchicine Derivatives
    Authors:
    Dominika Czerwonka, Szymon Sobczak, Tomasz Pędziński, Ewa Maj, Joanna Wietrzyk, Lech Celewicz, Andrzej Katrusiak, and Adam Huczyński*
    Academic press:
    Journal of Organic Chemistry (rok: 2021, ), Wydawca: ACS
    Status:
    Accepted for publication
    DOI:
    10.1021/acs.joc.0c02507 - link to the publication

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