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In search of specific inhibitors of myeloperoxidase, from mechanistic studies to application in enzymatic and cellular systems

2018/31/D/ST4/03494

Keywords

Descriptors

  • ST4_1: Chemia fizyczna
  • ST4_14: Reakcje chemiczne: mechanizmy, termodynamika, kinetyka i kataliza
  • ST4_16: Chemia jądrowa i radiacyjna

Panel

ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution

Politechnika Łódzka, Wydział Chemiczny

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Radosław Michalski

Number of co-investigators in the project: 3

Call

SONATA 14 – announced on 2018-09-14

Amount awarded
938 022 PLN
Project start date
2019-06-18
Project end date
2023-06-17
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Czytnik płytek studzienkowych (taki jak Varioskan Lux). Cost: 240 000 PLN

Information in the final report

Publication in academic press/journals (10)

  1. On the chemical reactivity of tricyanofuran (TCF)-based near-infrared fluorescent redox probes–Effects of glutathione on the probe response and product fluorescence

    Authors:
    Przemysław Siarkiewicz, Radosław Michalski, Adam Sikora, Renata Smulik-Izydorczyk, Marcin Szala, Aleksandra Grzelakowska, Julia Modrzejewska, Asha Bailey, Jacek E Nycz, Balaraman Kalyanaraman, Jan Grzegorz Malecki, Jacek Zielonka, Radosław Podsiadły
    Academic press:
    Dyes and Pigments (year: 2021, volume: 192, pages: 109405), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2021.109405 – link to the publication

  2. Oxidation of ethidium-based probes by biological radicals: mechanism, kinetics and implications for the detection of superoxide

    Authors:
    Radosław Michalski, David Thiebaut, Bartosz Michałowski, Mehmet M Ayhan, Micael Hardy, Olivier Ouari, Michał Rostkowski, Renata Smulik-Izydorczyk, Angelika Artelska, Andrzej Marcinek, Jacek Zielonka, Balaraman Kalyanaraman, Adam Sikora
    Academic press:
    Scientific Reports (year: 2020, volume: 10, pages: 46037), Publisher: Nature research
    Status:
    Published
    DOI:
    10.1038/s41598-020-75373-2 – link to the publication

  3. VEO-IBD NOX1 variant highlights a structural region essential for NOX/DUOX catalytic activity

    Authors:
    Josie Ward, Suisheng Zhang, Adam Sikora, Radosław Michalski, Yuting Yin, Aurora D'Alessio, Rachel McLoughlin, Vincent Jaquet, Franck Fieschi, Ulla G Knaus
    Academic press:
    Redox Biology (year: 2023, volume: 67, pages: 102905), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2023.102905 – link to the publication

  4. Fluorescent probes for monitoring myeloperoxidase‑derived hypochlorous acid: a comparative study

    Authors:
    Karolina Pierzchała, Marlena Pięta, Monika Rola, Małgorzata Świerczyńska, Angelika Artelska, Karolina Dębowska, Radosław Podsiadły, Jakub Pięta, Jacek Zielonka, Adam Sikora, Andrzej Marcinek, Radosław Michalski
    Academic press:
    Scientific Reports (year: 2022, volume: 12, pages: 9314), Publisher: Nature Publishing Group UK
    Status:
    Published
    DOI:
    10.1038/s41598-022-13317-8 – link to the publication

  5. The Chemistry of HNO: Mechanisms and Reaction Kinetics

    Authors:
    Radosław Michalski, Renata Smulik-Izydorczyk, Jakub Pięta, Monika Rola, Angelika Artelska, Karolina Pierzchała, Jacek Zielonka, Balaraman Kalyanaraman, Adam Bartłomiej Sikora
    Academic press:
    Frontiers in Chemistry (year: 2022, volume: 10, pages: brak), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fchem.2022.930657 – link to the publication

  6. A new and fast-response fluorescent probe for monitoring hypochlorous acid derived from myeloperoxidase

    Authors:
    Małgorzata Świerczyńska, Daniel Słowiński, Radosław Michalski, Jarosław Romański, Radosław Podsiadły
    Academic press:
    Molecules (year: 2023, volume: 28, pages: 6055), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28166055 – link to the publication

  7. Selective, stoichiometric and fast-response fluorescent probe based on 7-nitrobenz-2-oxa-1, 3-diazole fluorophore for hypochlorous acid detection

    Authors:
    Małgorzata Świerczyńska, Daniel Słowiński, Aleksandra Grzelakowska, Marcin Szala, Jarosław Romański, Karolina Pierzchała, Przemysław Siarkiewicz, Radosław Michalski, Radosław Podsiadły
    Academic press:
    Dyes and Pigments (year: 2021, volume: 193, pages: 109563), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2021.109563 – link to the publication

  8. A thiomorpholine-based fluorescent probe for the far-red hypochlorous acid monitoring

    Authors:
    Małgorzata Świerczyńska, Daniel Słowiński, Radosław Michalski, Jarosław Romański, Radosław Podsiadły
    Academic press:
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (year: 2023, volume: 289, pages: 122193), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.saa.2022.122193 – link to the publication

  9. Boronate-Based Oxidant-Responsive Derivatives of Acetaminophen as Proinhibitors of Myeloperoxidase

    Authors:
    Karolina Pierzchała, Jakub Pięta, Marlena Pięta, Monika Rola, Jacek Zielonka, Adam Sikora, Andrzej Marcinek, Radosław Michalski
    Academic press:
    Chemical Research in Toxicology (year: 2023, volume: XXXX, pages: XXX-XXX), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.chemrestox.3c00140 – link to the publication

  10. Boronate-based probes for biological oxidants: A novel class of molecular tools for redox biology

    Authors:
    Adam Bartlomiej Sikora, Jacek Zielonka, Karolina Dębowska, Radosław Michalski, Renata Smulik-Izydorczyk, Jakub Pięta, Radosław Podsiadły, Angelika Artelska, Karolina Pierzchała, Balaraman Kalyanaraman
    Academic press:
    Frontiers in Chemistry (year: 2020, volume: 8, pages: 11689), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fchem.2020.580899 – link to the publication

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Graphic design and implementation: Jakub Piotrowski