Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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In search of specific inhibitors of myeloperoxidase, from mechanistic studies to application in enzymatic and cellular systems

2018/31/D/ST4/03494

Keywords:

myeloperoxidase inhibitors proihnibitors hypochlorous acid hydrogen peroxide nitroxides hydroxamic acids salicylichydroxamic acid profluorescent probes boronic acids

Descriptors:

  • ST4_1: Physical chemistry, chemical physics
  • ST4_14: Catalysis
  • ST4_16: Ionic liquids

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Politechnika Łódzka, Wydział Chemiczny

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Radosław Michalski 

Number of co-investigators in the project: 3

Call: SONATA 14 - announced on 2018-09-14

Amount awarded: 938 022 PLN

Project start date (Y-m-d): 2019-06-18

Project end date (Y-m-d): 2023-06-17

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Czytnik płytek studzienkowych (taki jak Varioskan Lux) (240 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  1. On the chemical reactivity of tricyanofuran (TCF)-based near-infrared fluorescent redox probes–Effects of glutathione on the probe response and product fluorescence
    Authors:
    Przemysław Siarkiewicz, Radosław Michalski, Adam Sikora, Renata Smulik-Izydorczyk, Marcin Szala, Aleksandra Grzelakowska, Julia Modrzejewska, Asha Bailey, Jacek E Nycz, Balaraman Kalyanaraman, Jan Grzegorz Malecki, Jacek Zielonka, Radosław Podsiadły
    Academic press:
    Dyes and Pigments (rok: 2021, tom: 192, strony: 109405), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2021.109405 - link to the publication
  2. Oxidation of ethidium-based probes by biological radicals: mechanism, kinetics and implications for the detection of superoxide
    Authors:
    Radosław Michalski, David Thiebaut, Bartosz Michałowski, Mehmet M Ayhan, Micael Hardy, Olivier Ouari, Michał Rostkowski, Renata Smulik-Izydorczyk, Angelika Artelska, Andrzej Marcinek, Jacek Zielonka, Balaraman Kalyanaraman, Adam Sikora
    Academic press:
    Scientific Reports (rok: 2020, tom: 10, strony: 45306), Wydawca: Nature research
    Status:
    Published
    DOI:
    10.1038/s41598-020-75373-2 - link to the publication
  3. Fluorescent probes for monitoring myeloperoxidase‑derived hypochlorous acid: a comparative study
    Authors:
    Karolina Pierzchała, Marlena Pięta, Monika Rola, Małgorzata Świerczyńska, Angelika Artelska, Karolina Dębowska, Radosław Podsiadły, Jakub Pięta, Jacek Zielonka, Adam Sikora, Andrzej Marcinek, Radosław Michalski
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 9314), Wydawca: Nature Publishing Group UK
    Status:
    Published
    DOI:
    10.1038/s41598-022-13317-8 - link to the publication
  4. A thiomorpholine-based fluorescent probe for the far-red hypochlorous acid monitoring
    Authors:
    Małgorzata Świerczyńska, Daniel Słowiński, Radosław Michalski, Jarosław Romański, Radosław Podsiadły
    Academic press:
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (rok: 2023, tom: 289, strony: 122193), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.saa.2022.122193 - link to the publication
  5. Boronate-Based Oxidant-Responsive Derivatives of Acetaminophen as Proinhibitors of Myeloperoxidase
    Authors:
    Karolina Pierzchała, Jakub Pięta, Marlena Pięta, Monika Rola, Jacek Zielonka, Adam Sikora, Andrzej Marcinek, Radosław Michalski
    Academic press:
    Chemical Research in Toxicology (rok: 2023, tom: XXXX, strony: XXX-XXX), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.chemrestox.3c00140 - link to the publication
  6. Boronate-based probes for biological oxidants: A novel class of molecular tools for redox biology
    Authors:
    Adam Bartlomiej Sikora, Jacek Zielonka, Karolina Dębowska, Radosław Michalski, Renata Smulik-Izydorczyk, Jakub Pięta, Radosław Podsiadły, Angelika Artelska, Karolina Pierzchała, Balaraman Kalyanaraman
    Academic press:
    Frontiers in Chemistry (rok: 2020, tom: 8, strony: 11689), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fchem.2020.580899 - link to the publication
  7. The Chemistry of HNO: Mechanisms and Reaction Kinetics
    Authors:
    Radosław Michalski, Renata Smulik-Izydorczyk, Jakub Pięta, Monika Rola, Angelika Artelska, Karolina Pierzchała, Jacek Zielonka, Balaraman Kalyanaraman, Adam Bartłomiej Sikora
    Academic press:
    Frontiers in Chemistry (rok: 2022, tom: 10, strony: brak), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fchem.2022.930657 - link to the publication
  8. VEO-IBD NOX1 variant highlights a structural region essential for NOX/DUOX catalytic activity
    Authors:
    Josie Ward, Suisheng Zhang, Adam Sikora, Radosław Michalski, Yuting Yin, Aurora D'Alessio, Rachel McLoughlin, Vincent Jaquet, Franck Fieschi, Ulla G Knaus
    Academic press:
    Redox Biology (rok: 2023, tom: 67, strony: 102905), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2023.102905 - link to the publication
  9. A new and fast-response fluorescent probe for monitoring hypochlorous acid derived from myeloperoxidase
    Authors:
    Małgorzata Świerczyńska, Daniel Słowiński, Radosław Michalski, Jarosław Romański, Radosław Podsiadły
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 6055), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28166055 - link to the publication
  10. Selective, stoichiometric and fast-response fluorescent probe based on 7-nitrobenz-2-oxa-1, 3-diazole fluorophore for hypochlorous acid detection
    Authors:
    Małgorzata Świerczyńska, Daniel Słowiński, Aleksandra Grzelakowska, Marcin Szala, Jarosław Romański, Karolina Pierzchała, Przemysław Siarkiewicz, Radosław Michalski, Radosław Podsiadły
    Academic press:
    Dyes and Pigments (rok: 2021, tom: 193, strony: 109563), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2021.109563 - link to the publication

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