Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Inhibitors of BTLA-HVEM complex formation as potential targets for cancer immunotheraphy

2017/26/D/ST5/00919

Keywords:

inhibitors peptides BTLA HVEM immune checkpoints ELISA tests affinity chromatography

Descriptors:

  • ST5_16:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Gdański, Wydział Chemii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marta Spodzieja 

Number of co-investigators in the project: 4

Call: SONATA 13 - announced on 2017-06-14

Amount awarded: 1 233 000 PLN

Project start date (Y-m-d): 2018-03-21

Project end date (Y-m-d): 2023-03-20

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  1. Targeting BTLA with the peptide inhibitor HVEM(14-39)—a new way to the restore activity of T cells in melanoma
    Authors:
    Karolina Wojciechowicz, Katarzyna Kuncewicz, Jacek Rutkowski, Jacek Jassem, Sylwia Rodziewicz- Motowidło, Anna Wardowska, Marta Spodzieja
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2024, tom: 175, strony: 116675), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2024.116675 - link to the publication
  2. The effect of gD-derived peptides on T cell immune response mediated by BTLA-HVEM protein complex in melanoma patients
    Authors:
    Karolina Wojciechowicz, Katarzyna Kuncewicz, Jacek Rutkowski, Jacek Jassem, Anna Wardowska, Marta Spodzieja
    Academic press:
    Frontiers in Immunology (rok: 2024, tom: 15, strony: 1362152), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2024.1362152 - link to the publication
  3. BTLA-derived peptides as inhibitors of BTLA/HVEM complex formation – design, synthesis and biological evaluation
    Authors:
    Kuncewicz Katarzyna, Bojko Magdalena, Battin Claire, Karczyńska Agnieszka, Sieradzan Adam, Sikorska Emilia, Węgrzyn Katarzyna, Wojciechowicz Karolina, Wardowska Anna, Steinberger Peter, Rodziewicz-Motowidło Sylwia, Spodzieja Marta
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2023, tom: 165, strony: 115161), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2023.115161 - link to the publication
  4. Peptides targeting the BTLA-HVEM complex can modulate T cell immune response
    Authors:
    Karolina Wojciechowicz, Katarzyna Kuncewicz, Katarzyna A. Lisowska, Anna Wardowska, Marta Spodzieja
    Academic press:
    European Journal of Pharmaceutical Sciences (rok: 2024, tom: 193, strony: 106677), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejps.2023.106677 - link to the publication
  5. Targeting the HVEM protein using a fragment of glycoprotein D to inhibit formation of the BTLA/HVEM complex
    Authors:
    Kuncewicz Katarzyna, Battin Claire, Węgrzyn Katarzyna, Sieradzan Adam, Wardowska Anna, Sikorska Emilia, Giedrojć Irma, Smardz Pamela, Pikuła Michał, Steinberger Peter, Rodziewicz-Motowidło Sylwia, Spodzieja Marta
    Academic press:
    Bioorganic Chemistry (rok: 2022, tom: 122, strony: 45305), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2022.105748 - link to the publication
  6. The BTLA-HVEM complex – The future of cancer immunotherapy
    Authors:
    Karolina Wojciechowicz, Marta Spodzieja, Anna Wardowska
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2024, tom: 268, strony: 116231), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2024.116231 - link to the publication
  7. Disulfide-linked peptides for blocking BTLA/HVEM binding
    Authors:
    Marta Spodzieja, Katarzyna Kuncewicz, Adam Sieradzan, Agnieszka Karczyńska, Justyna Iwaszkiewicz, Valérie Cesson, Katarzyna Węgrzyn, Igor Zhukov, Martyna Maszota-Zieleniak, Olivier Michielin, Daniel E. Speiser, Vincent Zoete, Laurent Derre, Sylwia Rodziewicz-Motowidło
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21(2), strony: 636), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21020636 - link to the publication
  8. Fragments of gD protein as inhibitors of BTLA/HVEM complex formation-design, synthesis, and cellular studies
    Authors:
    Katarzyna Kuncewicz, Claire Battin, Adam Sieradzan, Agnieszka Karczyńska, Marta Orlikowska, Anna Wardowska, Michał Pikuła, Peter Steinberger, Sylwia Rodziewicz-Motowidło, Marta Spodzieja
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21(22), strony: 8876), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21228876 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy