Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Structure and function characterization of newly discovered unique inhibitors of proteases

2016/21/B/NZ1/00292

Keywords:

enzyme protease regulation proteolysis proteinaceous inhibitor mechanism of inhibition crystallographic structure

Descriptors:

  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jan Potempa 

Number of co-investigators in the project: 4

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 2 193 900 PLN

Project start date (Y-m-d): 2017-02-15

Project end date (Y-m-d): 2020-05-14

Project duration:: 39 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komora HS KS z wyposażeniem.
  2. Tube Roller.
  3. Instrument to badania mechanizmów oddziaływań międzycząsteczkowych, w tym kinetyki, w oparciu o zjawisko powierzchniowych fal akustycznych (500 000 PLN)
  4. Inkubator CO2 Midi 40.

Information in the final report

  • Publication in academic press/journals (4)
  1. In vivo expression of proteases and protease inhibitor, a serpin, by periodontal pathogens at teeth and implants.
    Authors:
    Eckert M, Mizgalska D, Sculean A, Potempa J, Stavropoulos A, Eick S.
    Academic press:
    Molecular Oral Microbiology (rok: 2018, tom: 33, strony: 240-248), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/omi.12220 - link to the publication
  2. Complement Activation as a Helping Hand for Inflammophilic Pathogens and Cancer.
    Authors:
    Okrój M, Potempa J
    Academic press:
    Frontiers Immunology (rok: 2019, tom: 9, strony: 3125), Wydawca: www.frontiersin.org
    Status:
    Published
    DOI:
    10.3389/fimmu.2018.03125 - link to the publication
  3. A unique network of attack, defence and competence on the outer membrane of the periodontitis pathogen Tannerella forsythia
    Authors:
    Książek M, Goulas T, Mizgalska D, Rodríguez-Banqueri A, Eckhard U, Veillard F, Waligórska I, Benedyk-Machaczka M, Sochaj-Gregorczyk AM, Madej M, Thøgersen IB, Enghild JJ, Cuppari A, Arolas JL, de Diego I, López-Pelegrín M, Garcia-Ferrer I, Guevara T, Dive V, Zani ML, Moreau T, Potempa J, Gomis-Rüth FX.
    Academic press:
    Chemical Science (rok: 2023, tom: 14, strony: 869-888), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d2sc04166a - link to the publication
  4. Analysis of Oral Microbiome From Fossil Human Remains Revealed the Significant Differences in Virulence Factors of Modern and Ancient Tannerella Forsythia
    Authors:
    Philips A, Stolarek I, Handschuh L, Nowis K, Juras A, Trzciński D, Nowaczewska W, Wrzesińska A, Potempa J, Figlerowicz M.
    Academic press:
    BMC Genomics (rok: 2020, tom: 21, strony: 402), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12864-020-06810-9 - link to the publication

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