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Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Design, chemical synthesis and biological activity of inhibitors of matriptase-2.

2014/13/N/ST5/01299

Keywords:

matriptase-2 serine proteinases inhibitors peptides

Descriptors:

  • ST5_16:
  • ST5_23:
  • NZ1_2: Biochemistry

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Gdański, Wydział Chemii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Agata Gitlin-Domagalska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 7 - announced on 2014-03-17

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2015-02-12

Project end date (Y-m-d): 2018-02-11

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Platforma do wytrząsarki typ 358A.
  2. Wyparka próżniowa (20 000 PLN)
  3. Zespół napędowy do wytrząsarki typ 358A.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (1)
  1. Inhibitors of Matriptase-2 Based on the Trypsin Inhibitor SFTI-1.
    Authors:
    Gitlin A., Dębowski D., Karna N., Łęgowska A., Stirnberg M., Gütschow M., Rolka K.
    Academic press:
    ChemBioChem (rok: 2015, tom: 16, strony: 1601-1607), Wydawca: WILEY-BLACKWELL
    Status:
    Published
    DOI:
    10.1002/cbic.201500200 - link to the publication
  2. Matriptase-2: monitoring and inhibiting its proteolytic activity
    Authors:
    Gitlin-Domagalska A., Mangold M., Dębowski D., Łęgowska A., Gütschow M., Rolka K.,
    Academic press:
    Future Med. Chem. (rok: 2018, tom: 10, strony: 2745–2761), Wydawca: Future Science
    Status:
    Published
    DOI:
    0.4155/fmc-2018-0346 - link to the publication
  3. Design and chemical syntheses of potent matriptase-2 inhibitors based on trypsin inhibitor SFTI-1 isolated from sunflower seeds
    Authors:
    Gitlin-Domagalska A., Dębowski D., Łęgowska A., Stirnberg M., Okońska J., Gütschow M., Rolka K.
    Academic press:
    Biopolymers. Peptide Science (rok: 2017, tom: 108, strony: e23031), Wydawca: New York, NY : Wiley
    Status:
    Published
    DOI:
    10.1002/bip.23031 - link to the publication
  1. Designing and chemical syntheses of selective matriptase-2 inhibitors based on trypsin inhibitor SFTI-1 isolated from sunflower seeds
    Authors:
    Gitlin-Domagalska A., Dębowski D., Ptaszyńska (Karna) N., Łęgowska A., Stirnberg M., Gütschow M., Rolka K
    Conference:
    34th European Peptide Symposium (rok: 2017, ), Wydawca: European Peptide Society, Proceedings of the 34th European Peptide Symposium and the 8th International Peptide Symposium, edited by: A. Beck-Sickinger, K. Mörl, K. Bellmann-Sickert, S. Els-Heindl.
    Data:
    konferencja 04-09.09.2016
    Status:
    Published
    DOI:
    link to the publication

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