Projects funded by the NCN
Allosteric inhibitors of proteasome - optimization of the structure of PR39 analogs in order to achieve greater efficiency and stability
2016/23/N/ST5/02812
Keywords:
proteasome inhibitors allostery PR39
Descriptors:
- ST5_16:
Panel:
ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution :
Uniwersytet Gdański, Wydział Chemii
woj. pomorskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 12 - announced on 2016-09-15
Amount awarded: 99 900 PLN
Project start date (Y-m-d): 2017-09-27
Project end date (Y-m-d): 2019-09-26
Project duration:: 24 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- Proline- and arginine-rich peptides as flexible allosteric modulators of human proteasome activityAuthors:Małgorzata Giżyńska, Julia Witkowska, Przemysław Karpowicz, Rafał Rostankowski, Estrella S. Chocron, Andrew M. Pickering, Pawel Osmulski, Maria Gaczynska, Elżbieta JankowskaAcademic press:Journal of Medicinal Chemistry (rok: 2019, tom: 62, strony: 359–370), Wydawca: ACS PublicationsStatus:PublishedDOI:10.1021/acs.jmedchem.8b01025 - link to the publication