Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Use of novel small molecule inhibitors of PERK kinase dependent UPR pathway for the primary open-angle glaucoma treatment

2016/21/B/NZ5/01411

Keywords:

PERK inhibitors glaucoma

Descriptors:

  • NZ5_3:
  • NZ5_5:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ireneusz Jacek Majsterek 

Number of co-investigators in the project: 7

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 986 700 PLN

Project start date (Y-m-d): 2017-03-08

Project end date (Y-m-d): 2023-05-07

Project duration:: 74 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Aparat ChemiDoc MP system do Western Blott (130 000 PLN)

Information in the final report

  • Publication in academic press/journals (16)
  • Articles in post-conference publications (12)
  1. The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases
    Authors:
    Wioletta Rozpedek-Kaminska, Natalia Siwecka, Adam Wawrzynkiewicz, Radosław Wojtczak, Dariusz Pytel, J. Alan Diehl, Ireneusz Majsterek
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, 2108, strony: 14611), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21062108 - link to the publication
  2. Inhibition of the PERK-dependent Unfolded Protein Response Signaling Pathway Involved in the Pathogenesis of Alzheimer's Disease
    Authors:
    Wioletta Rozpedek, Dariusz Pytel, Tomasz Popławski, Anna Walczak, Kinga Gradzik, Adam Wawrzynkiewicz, Radosław Wojtczak, Bartosz Mucha, J. Alan Diehl, and Ireneusz Majsterek
    Academic press:
    Current Alzheimer Research, 2019, 16, 1-10 (rok: 2019, tom: 16, strony: 45667), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    10.2174/1567205016666190228121157 - link to the publication
  3. Inhibition of the PERK-dependent Unfolded Protein Response Signaling Pathway Involved in the Pathogenesis of Alzheimer's Disease
    Authors:
    Wioletta Rozpedek, Dariusz Pytel, Tomasz Popławski, Anna Walczak, Kinga Gradzik, Adam Wawrzynkiewicz, Radosław Wojtczak, Bartosz Mucha, J. Alan Diehl, and Ireneusz Majsterek
    Academic press:
    Current Alzheimer Research, 2019, 16, 1-10 (rok: 2019, tom: 16, strony: 45667), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    10.2174/1567205016666190228121157 - link to the publication
  4. Inhibitor of pro-apoptotic PERK-dependent signaling pathway as a novel treatment strategy in Alzheimer's disease treatment
    Authors:
    Wioletta Rozpędek, Justyna Basak, Igor Sokołowski, Radosław Wojtczak, Dariusz Pytel, J. Alan Diehl, Ireneusz Majsterek
    Academic press:
    Farmakoterapia w Psychiatrii i Neurologii (rok: 2019, tom: 35 (1), strony: 25-36), Wydawca: Instytut Psychiatrii i Neurologii
    Status:
    Published
    DOI:
    10.33450/fpn.2019.03.003 - link to the publication
  5. Association of the expression level of the neurodegeneration-related proteins with the risk of development and progression of primary open-angle glaucoma
    Authors:
    Alicja Nowak, Wioletta Rozpezdek, Magda Cuchra, Radosław Wojtczak, Mateusz Siwak, Katarzyna Szymanek, Marta Szaflik, Jerzy Szaflik, Jacek Szaflik, Ireneusz Majsterek
    Academic press:
    Acta Ophthalmologica (rok: 2018, tom: 2018, strony: 97-98), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/aos.13479 - link to the publication
  6. The Structure, Activation and Signaling of IRE1 and Its Role in Determining Cell Fate
    Authors:
    Natalia Siwecka, Wioletta Rozpedek-Kaminska, Adam Wawrzynkiewicz, Dariusz Pytel, J. Alan Diehl, Ireneusz Majsterek
    Academic press:
    Biomedicines (rok: 2021, tom: 9, 156, strony: 45686), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines9020156 - link to the publication
  7. Small‐molecule PKR‐like endoplasmic reticulum kinase inhibitors as a novel targeted therapy for Parkinson's disease
    Authors:
    WERONIKA LUSA, WIOLETTA ROZPĘDEK‐KAMIŃSKA, NATALIA SIWECKA, GRZEGORZ GALITA, IRENEUSZ MAJSTEREK, EWA KUCHARSKA
    Academic press:
    MOLECULAR MEDICINE REPORTS (rok: 2023, tom: 27: 102, strony: 45672), Wydawca: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/mmr.2023.12989 - link to the publication
  8. Small-molecule inhibitors of the PERK-dependent Unfolded Protein Response signaling pathway as a novel treatment strategy against Alzheimer's disease
    Authors:
    WIOLETTA ROZPĘDEK, DARIUSZ PYTEL, J. ALAN DIEHL, IRENEUSZ MAJSTEREK
    Academic press:
    Polski Merkuriusz Lekarski (rok: 2019, tom: XLVI (271), strony: 51-57), Wydawca: MEDPRESS
    Status:
    Published
  9. Inhibitor of pro-apoptotic PERK-dependent signaling pathway as a novel treatment strategy in Alzheimer's disease treatment
    Authors:
    Wioletta Rozpędek, Justyna Basak, Igor Sokołowski, Radosław Wojtczak, Dariusz Pytel, J. Alan Diehl, Ireneusz Majsterek
    Academic press:
    Farmakoterapia w Psychiatrii i Neurologii (rok: 2019, tom: 35 (1), strony: 25-36), Wydawca: Instytut Psychiatrii i Neurologii
    Status:
    Published
    DOI:
    10.33450/fpn.2019.03.003 - link to the publication
  10. The Potential Role of Small-Molecule PERK Inhibitor LDN-0060609 in Primary Open-Angle Glaucoma Treatment
    Authors:
    Wioletta Rozpedek-Kaminska, Grzegorz Galita, Natalia Siwecka 1 , Steven L. Carroll, John Alan Diehl, Ewa Kucharska, Dariusz Pytel, Ireneusz Majsterek
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, 4494, strony: 12055), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094494 - link to the publication
  11. Analysis of the polymorphic variants of RAN and GEMIN3 genes and risk of Primary Open-Angle Glaucoma in the Polish population
    Authors:
    Milena Molasy, Anna Walczak, Karolina Przybyłowska-Sygut, Anna Zaleska-Żmijewska, Jerzy Szaflik, Jacek P. Szaflik, Ireneusz Majsterek
    Academic press:
    Ophthalmic Genetics (rok: 2018, tom: VOL. 39, NO. 2,, strony: 180-188), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.2017.1381978 - link to the publication
  12. The relationship between HDAC6, CXCR3, and SIRT1 genes expression levels with progression of primary open-angle glaucoma
    Authors:
    Mateusz Siwak, Marcin Maślankiewicz, Alicja Nowak-Zduńczyk, Wioletta Rozpędek, Radosław Wojtczak, Katarzyna Szymanek, Marta Szaflik, Jerzy Szaflik, Jacek P Szaflik, Ireneusz Majsterek
    Academic press:
    Ophthalmic Genetics (rok: 2018, tom: 2018, strony: 45664), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.2018.1432061 - link to the publication
  13. Potencjalne zastosowanie terapeutyczne inhibitorów PERK
    Authors:
    Justyna Basak, Wioletta Rozpędek, Dariusz Pytel, Ireneusz Majsterek
    Academic press:
    Postępy Biochemii (rok: 2019, tom: brak, strony: 45666), Wydawca: Polish Biochemical Society
    Status:
    Published
  14. Small‐molecule PKR‐like endoplasmic reticulum kinase inhibitors as a novel targeted therapy for Parkinson's disease
    Authors:
    WERONIKA LUSA, WIOLETTA ROZPĘDEK‐KAMIŃSKA, NATALIA SIWECKA, GRZEGORZ GALITA, IRENEUSZ MAJSTEREK, EWA KUCHARSKA
    Academic press:
    MOLECULAR MEDICINE REPORTS (rok: 2023, tom: 27: 102, strony: 45672), Wydawca: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/mmr.2023.12989 - link to the publication
  15. The Genetic and Endoplasmic Reticulum-Mediated Molecular Mechanisms of Primary Open-Angle Glaucoma
    Authors:
    Wioletta Rozpedek-Kaminska, Radosław Wojtczak, Jacek P. Szaflik, Jerzy Szaflik, Ireneusz Majsterek
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 13516), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21114171 - link to the publication
  16. Small-molecule inhibitors of the PERK-dependent Unfolded Protein Response signaling pathway as a novel treatment strategy against Alzheimer's disease
    Authors:
    WIOLETTA ROZPĘDEK, DARIUSZ PYTEL, J. ALAN DIEHL, IRENEUSZ MAJSTEREK
    Academic press:
    Polski Merkuriusz Lekarski (rok: 2019, tom: XLVI (271), strony: 51-57), Wydawca: MEDPRESS
    Status:
    Published
    DOI:
    brak - link to the publication
  1. Innovative approach to primary open-angle glaucoma treatment
    Authors:
    Julia Barczuk, Grzegorz Galita, Natalia Siwecka, Wioletta Rozpędek-Kamińska, Ireneusz Majsterek
    Conference:
    IX Ogólnopolskie Sympozjum Biomedyczne ESKULAP (rok: 2022, ), Wydawca: ESKULAP, Lublin
    Data:
    konferencja 3 grudnia 2022
    Status:
    Published
  2. SMALL-MOLECULE PERK INHIBITORS IN PRIMARY OPEN-ANGLE GLAUCOMA TREATMENT
    Authors:
    Julia Barczuk, Wioletta Rozpędek-Kamińska, Grzegorz Galita, Natalia Siwecka, Julia Barczuk, Ireneusz Majsterek
    Conference:
    National Scientific Conference "Science and Young Researchers" VI Edition (rok: 2022, ), Wydawca: PRomovenDI
    Data:
    konferencja 4 czerwiec 2022
    Status:
    Published
  3. Reactions of radicals with PERK kinase inhibitor under oxidative and reductive stress conditions. Pulse radiolysis study
    Authors:
    Karolina Radomska, Wioletta Rozpędek, Marian Wolszczak, Ireneusz Majsterek
    Conference:
    The 17th Annual Congress of International Drug Discovery Science & Technology (rok: 2019, ), Wydawca: BIT's 17th Annual Congress of International Drug Discovery Science & Technology-2019
    Data:
    konferencja 2019-07-25/2019-07-27
    Status:
    Published
  4. Small-molecule inhibitors of PERK-dependent signaling pathway as a novel strategy in open-angle glaucoma treatment
    Authors:
    Adam Wawrzynkiewicz, Natalia Siwecka, Wioletta Rozpedek-Kaminska, Dariusz Pytel, J. Alan Diehl, Ireneusz Majsterek
    Conference:
    Juvenes Pro Medicina (rok: 2020, ), Wydawca: Medical University of Lodz
    Data:
    konferencja 15-16 May
    Status:
    Published
  5. SMALL-MOLECULE PERK INHIBITORS IN PRIMARY OPEN-ANGLE GLAUCOMA TREATMENT
    Authors:
    Julia Barczuk, Wioletta Rozpędek-Kamińska, Grzegorz Galita, Natalia Siwecka, Julia Barczuk, Ireneusz Majsterek
    Conference:
    National Scientific Conference "Science and Young Researchers" VI Edition (rok: 2022, ), Wydawca: PRomovenDI
    Data:
    konferencja 4 czerwiec 2022
    Status:
    Published
  6. Small-molecule inhibitors of PERK-dependent signaling pathway as a novel strategy in open-angle glaucoma treatment
    Authors:
    Adam Wawrzynkiewicz, Natalia Siwecka, Wioletta Rozpedek-Kaminska, Dariusz Pytel, J. Alan Diehl, Ireneusz Majsterek
    Conference:
    Juvenes Pro Medicina (rok: 2020, ), Wydawca: Medical University of Lodz
    Data:
    konferencja 15-16 May
    Status:
    Published
  7. Innovative approach to primary open-angle glaucoma treatment
    Authors:
    Julia Barczuk, Grzegorz Galita, Natalia Siwecka, Wioletta Rozpędek-Kamińska, Ireneusz Majsterek
    Conference:
    IX Ogólnopolskie Sympozjum Biomedyczne ESKULAP (rok: 2022, ), Wydawca: ESKULAP, Lublin
    Data:
    konferencja 3 grudnia 2022
    Status:
    Published
  8. Neuroprotective effect of UPR inhibitor in Parkinson's Disease cellular model
    Authors:
    Zuzanna Granek
    Conference:
    INTERNATIONAL MEDICAL CONGRESS OF SILESIA (rok: 2023, ), Wydawca: STUDENTS' SCIENTIFIC ASSOCIATION OF MEDICAL UNIVERSITY OF SILESIA
    Data:
    konferencja 17-19 maj 2023
    Status:
    Published
  9. USE OF SMALL-MOLECULE PERK INHIBITORS IN PRIMARY OPEN-ANGLE GLAUCOMA TREATMENT
    Authors:
    Wioletta Rozpędek-Kamińska, Julia Barczuk, Grzegorz Galita, Natalia Siwecka, Julia Barczuk, Ireneusz Majsterek
    Conference:
    National Scientific Conference "Science and Young Researchers" VI Edition (rok: 2022, ), Wydawca: PRomovenDI
    Data:
    konferencja 4 czerwiec 2022
    Status:
    Published
  10. Neuroprotective effect of UPR inhibitor in Parkinson's Disease cellular model
    Authors:
    Zuzanna Granek
    Conference:
    INTERNATIONAL MEDICAL CONGRESS OF SILESIA (rok: 2023, ), Wydawca: STUDENTS' SCIENTIFIC ASSOCIATION OF MEDICAL UNIVERSITY OF SILESIA
    Data:
    konferencja 17-19 maj 2023
    Status:
    Published
  11. Procesy redoks inhibitorów kinazy PERK w warunkach stresu utleniającego i redukującego. Pomiary radiolizy impulsowej.
    Authors:
    Karolina Radomska, Ireneusz Majsterek, Marian Wolszczak
    Conference:
    62. Zjazd Naukowy Polskiego Towarzystwa Chemicznego (rok: 2019, ), Wydawca: Polskie Towarzystwo Chemiczne, ul. Freta 16, 00-227 Warszawa
    Data:
    konferencja 2019-06-02/2019-09-06
    Status:
    Published
  12. USE OF SMALL-MOLECULE PERK INHIBITORS IN PRIMARY OPEN-ANGLE GLAUCOMA TREATMENT
    Authors:
    Wioletta Rozpędek-Kamińska, Julia Barczuk, Grzegorz Galita, Natalia Siwecka, Julia Barczuk, Ireneusz Majsterek
    Conference:
    National Scientific Conference "Science and Young Researchers" VI Edition (rok: 2022, ), Wydawca: PRomovenDI
    Data:
    konferencja 4 czerwiec 2022
    Status:
    Published

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