Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The significance of cancer specific PFK-II (PFKFB3 and PFKFB4) isoenzymes inhibition in overcoming resistance to BRAF inhibitors in malignant melanoma therapy

2018/31/N/NZ5/03561

Keywords:

6-phosphofructo-20kinase/fructose-2,6-bisphosphatase malignant melanoma glucose metabolism BRAF inhibitors

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Sonia Trojan 

Number of co-investigators in the project: 3

Call: PRELUDIUM 16 - announced on 2018-09-14

Amount awarded: 209 929 PLN

Project start date (Y-m-d): 2019-08-01

Project end date (Y-m-d): 2024-07-31

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. The Warburg efect: a score for many instruments in the concert of cancer and cancer niche cells
    Authors:
    Martyna Jaworska, Julia Szczudło, Adrian Pietrzyk, Jay Shah, Sonia E. Trojan, Barbara Ostrowska, Kinga A. Kocemba‑Pilarczyk
    Academic press:
    Pharmacological Reports (rok: 2023, tom: 75, strony: 876-890), Wydawca: SPRINGER HEIDELBERG
    Status:
    Published
    DOI:
    10.1007/s43440-023-00504-1 - link to the publication
  2. The influence of PFK-II overexpression on neuroblastoma patients' survival may be dependent on the particular isoenzyme expressed, PFKFB3 or PFKFB4
    Authors:
    Sonia E. Trojan, Michał J. Markiewicz, Katarzyna Leśkiewicz & Kinga A. Kocemba-Pilarczyk
    Academic press:
    Cancer Cell International (rok: 2019, tom: 0,994444444444444, strony: 679-685), Wydawca: BioMed Central Part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12935-019-1005-9 - link to the publication
  3. Expression of Alternative Splice Variants of 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase-4 in Normoxic and Hypoxic Melanoma Cells
    Authors:
    Sonia E. Trojan, Paulina Dudzik, Justyna Totoń-Żurańska, Piotr Laidler, Kinga A. Kocemba-Pilarczyk
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(16), strony: nr pierwszej strony 8848; 17 stron), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22168848 - link to the publication

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