Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Interaction and PK/PD studies of phosphodiesterase inhibitors in a murine model of autoimmune hepatitis

2018/29/N/NZ7/00432

Keywords:

autoimmune hepatitis phosphodiesterase inhibitors interactions PK/PD analysis

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Artur Świerczek 

Number of co-investigators in the project: 2

Call: PRELUDIUM 15 - announced on 2018-03-15

Amount awarded: 209 900 PLN

Project start date (Y-m-d): 2019-01-21

Project end date (Y-m-d): 2023-01-20

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator CO2 (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. PK/PD Modeling of the PDE7 Inhibitor—GRMS-55 in a Mouse Model of Autoimmune Hepatitis
    Authors:
    Artur Świerczek, Hanna Plutecka, Marietta Ślusarczyk, Grażyna Chłoń-Rzepa, Elżbieta Wyska
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13, strony: 597), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13050597 - link to the publication
  2. Comparative Assessment of the New PDE7 Inhibitor - GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach
    Authors:
    Artur Świerczek, Krzysztof Pociecha, Marietta Ślusarczyk, Grażyna Chłoń-Rzepa, Sebastian Baś, Jacek Młynarski, Krzysztof Więckowski, Monika Zadrożna, Barbara Nowak, Elżbieta Wyska
    Academic press:
    Pharmaceutical Research (rok: 2020, tom: 1,55486111111111, strony: 45312), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s11095-019-2727-z - link to the publication
  3. Pharmacokinetic/Pharmacodynamic Assessment of Selective Phosphodiesterase Inhibitors in a Mouse Model of Autoimmune Hepatitis
    Authors:
    Artur Świerczek, Bartosz Pomierny, Elżbieta Wyska, William J. Jusko
    Academic press:
    Journal of Pharmacology and Experimental Therapeutics (rok: 2022, tom: 381(2), strony: 151-163), Wydawca: American Society for Pharmacology and Experimental Therapeutics
    Status:
    Published
    DOI:
    10.1124/jpet.121.001004 - link to the publication
  4. New imidazopyridines with phosphodiesterase 4 and 7 inhibitory activity and their efficacy in animal models of inflammatory and autoimmune diseases
    Authors:
    Veronika Ručilová, Artur Świerczek, David Vanda, Petr Funk, Barbora Lemrová, Alicja Gawalska, Adam Bucki, Barbara Nowak, Monika Zadrożna, Krzysztof Pociecha, Miroslav Soural, Elżbieta Wyska, Maciej Pawłowski, Grażyna Chłoń-Rzepa, Paweł Zajdel
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2021, tom: 209, strony: 112854), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2020.112854 - link to the publication

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