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Histidine Biosynthetic Pathway in Plants: Structural and Functional Studies as a Framework for the Design of Inhibitors and Activators

2018/31/D/NZ1/03630

Keywords:

protein crystallography plant structural biology inhibitor design enzymology histidine biosynthesis biosynthetic pathways

Descriptors:

  • NZ1_4:
  • NZ1_1:
  • NZ1_2:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Miłosz Ruszkowski 

Number of co-investigators in the project: 3

Call: SONATA 14 - announced on 2018-09-14

Amount awarded: 1 442 800 PLN

Project start date (Y-m-d): 2019-09-26

Project end date (Y-m-d): 2023-08-25

Project duration:: 47 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (9)
  • Articles in post-conference publications (2)
  1. Legume-type glutamate dehydrogenase: Structure, activity, and inhibition studies
    Authors:
    Marta Grzechowiak, Joanna Sliwiak, Andreas Link, Milosz Ruszkowski
    Academic press:
    International Journal of Biological Macromolecules (rok: 2024, tom: 278(P2), strony: 134648), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2024.134648 - link to the publication
  2. Serendipitous crystallization of E. coli HPII catalase, a sequel to the tale usually not told"
    Authors:
    Marta Grzechowiak, Bartosz Sekula, Mariusz Jaskolski, Milosz Ruszkowski
    Academic press:
    Acta Biochimica Polonica (rok: 2021, tom: 68, strony: epub 5501), Wydawca: Polish Biochemical Society
    Status:
    Published
    DOI:
    10.18388/abp.2020_5501 - link to the publication
  3. Insights into the substrate specificity, structure, and dynamics of plant histidinol-phosphate aminotransferase (HISN6)
    Authors:
    Maria Rutkiewicz, Isabel Nogues, Wojciech Witek, Sebastiana Angelaccio, Roberto Contestabile , Milosz Ruszkowski
    Academic press:
    Plant Physiology and Biochemistry (rok: 2023, tom: 196, strony: 759-773), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.plaphy.2023.02.017 - link to the publication
  4. Structural Studies of Glutamate Dehydrogenase (Isoform 1) From Arabidopsis thaliana, an Important Enzyme at the Branch-Point Between Carbon and Nitrogen Metabolism
    Authors:
    Marta Grzechowiak, Joanna Sliwiak, Mariusz Jaskolski, Milosz Ruszkowski
    Academic press:
    Frontiers in Plant Science (rok: 2020, tom: 11, strony: epub 754), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fpls.2020.00754 - link to the publication
  5. Structural, kinetic, and evolutionary peculiarities of HISN3, a plant 5′-ProFAR isomerase
    Authors:
    Wojciech Witek, Barbara Imiolczyk, Milosz Ruszkowski
    Academic press:
    Plant Physiology and Biochemistry (rok: 2024, tom: 215(3), strony: 109065), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.plaphy.2024.109065 - link to the publication
  6. Deciphering the structure of Arabidopsis thaliana 5-enol-pyruvyl- shikimate-3-phosphate synthase: An essential step toward the discovery of novel inhibitors to supersede glyphosate
    Authors:
    Milosz Ruszkowski, Giuseppe Forlani
    Academic press:
    Computational and Structural Biotechnology Journal (rok: 2022, tom: 20, strony: 1494-1505), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.csbj.2022.03.020 - link to the publication
  7. Structural and mechanistic insights into the bifunctional HISN2 enzyme catalyzing the second and third steps of histidine biosynthesis in plants
    Authors:
    Wojciech Witek, Joanna Sliwiak, Milosz Ruszkowski
    Academic press:
    Scientific Reports (rok: 2021, tom: 11, strony: 9647), Wydawca: Nature Springer
    Status:
    Published
    DOI:
    10.1038/s41598-021-88920-2 - link to the publication
  8. Structural and functional studies of Arabidopsis thaliana glutamate dehydrogenase isoform 2 demonstrate enzyme dynamics and identify its calcium binding site
    Authors:
    Marta Grzechowiak, Joanna Sliwiak, Mariusz Jaskolski, Milosz Ruszkowski
    Academic press:
    Plant Physiology and Biochemistry (rok: 2023, tom: 201, strony: 107895), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.plaphy.2023.107895 - link to the publication
  9. Targeting imidazole-glycerol phosphate dehydratase in plants: novel approach for structural and functional studies, and inhibitor blueprinting.
    Authors:
    Wojciech Witek, Joanna Sliwiak, Michal Rawski, Milosz Ruszkowski
    Academic press:
    Frontiers in Plant Science (rok: 2024, tom: 15, strony: 1343980), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fpls.2024.1343980 - link to the publication
  1. Structural studies of the histidine biosynthetic pathway in plants towards the discovery of novel herbicides
    Authors:
    Wojciech Witek, Joanna Sliwiak, Maria Rutkiewicz, Zbigniew Dauter, Milosz Ruszkowski
    Conference:
    Structural drug design 2023: biology, chemistry and computers (rok: 2023, ), Wydawca: Ettore Majorana Foundation and Centre for Scientific Culture
    Data:
    konferencja czerwiec 2023
    Status:
    Published
  2. Structural and Functional Characterization of the Histidine Biosynthetic Pathway in Plants
    Authors:
    Wojciech Witek, Milosz Ruszkowski
    Conference:
    Gordon Research Conference: Enzymes, Coenzymes and Metabolic Pathways (rok: 2023, ), Wydawca: Gordon Research Conferences
    Data:
    konferencja lipiec 2023
    Status:
    Published

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