Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Histidine Biosynthetic Pathway in Plants: Structural and Functional Studies as a Framework for the Design of Inhibitors and Activators

2018/31/D/NZ1/03630

Keywords:

protein crystallography plant structural biology inhibitor design enzymology histidine biosynthesis biosynthetic pathways

Descriptors:

  • NZ1_4:
  • NZ1_1:
  • NZ1_2:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Miłosz Ruszkowski 

Number of co-investigators in the project: 3

Call: SONATA 14 - announced on 2018-09-14

Amount awarded: 1 442 800 PLN

Project start date (Y-m-d): 2019-09-26

Project end date (Y-m-d): 2023-08-25

Project duration:: 47 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (2)
  1. Structural Studies of Glutamate Dehydrogenase (Isoform 1) From Arabidopsis thaliana, an Important Enzyme at the Branch-Point Between Carbon and Nitrogen Metabolism
    Authors:
    Marta Grzechowiak, Joanna Sliwiak, Mariusz Jaskolski, Milosz Ruszkowski
    Academic press:
    Frontiers in Plant Science (rok: 2020, tom: 11, strony: epub 754), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fpls.2020.00754 - link to the publication
  2. Structural, kinetic, and evolutionary peculiarities of HISN3, a plant 5′-ProFAR isomerase
    Authors:
    Wojciech Witek, Barbara Imiolczyk, Milosz Ruszkowski
    Academic press:
    Plant Physiology and Biochemistry (rok: 2024, tom: 215(3), strony: 109065), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.plaphy.2024.109065 - link to the publication
  3. Legume-type glutamate dehydrogenase: Structure, activity, and inhibition studies
    Authors:
    Marta Grzechowiak, Joanna Sliwiak, Andreas Link, Milosz Ruszkowski
    Academic press:
    International Journal of Biological Macromolecules (rok: 2024, tom: 278(P2), strony: 134648), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2024.134648 - link to the publication
  1. Structural and Functional Characterization of the Histidine Biosynthetic Pathway in Plants
    Authors:
    Wojciech Witek, Milosz Ruszkowski
    Conference:
    Gordon Research Conference: Enzymes, Coenzymes and Metabolic Pathways (rok: 2023, ), Wydawca: Gordon Research Conferences
    Data:
    konferencja lipiec 2023
    Status:
    Published
  2. Structural studies of the histidine biosynthetic pathway in plants towards the discovery of novel herbicides
    Authors:
    Wojciech Witek, Joanna Sliwiak, Maria Rutkiewicz, Zbigniew Dauter, Milosz Ruszkowski
    Conference:
    Structural drug design 2023: biology, chemistry and computers (rok: 2023, ), Wydawca: Ettore Majorana Foundation and Centre for Scientific Culture
    Data:
    konferencja czerwiec 2023
    Status:
    Published

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