Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Analysis of the effectiveness of anticancer activity of tyrosine kinase inhibitors combined with nanoparticles in in vitro model of non-small cell lung cancer lines using spectroscopic methods

2016/21/D/ST4/02178

Keywords:

tyrosine kinase inhibitors colloidal nanoparticles vibrational spectroscopy

Descriptors:

  • ST4_3: Molecular architecture and structure
  • ST4_4: Theoretical and computational chemistry
  • ST4_5: Analytical chemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Instytut Fizyki Jądrowej im. Henryka Niewodniczańskiego Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Natalia Piergies 

Number of co-investigators in the project: 2

Call: SONATA 11 - announced on 2016-03-15

Amount awarded: 390 440 PLN

Project start date (Y-m-d): 2017-01-17

Project end date (Y-m-d): 2022-01-16

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Oprogramowanie naukowo - techniczne Matlab (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  • Articles in post-conference publications (4)
  1. Vibrational Fingerprint of Erlotinib: FTIR, RS, and DFT Studies
    Authors:
    N. Piergies, C. Paluszkiewicz, W.M. Kwiatek
    Academic press:
    Journal of Spectroscopy (rok: 2019, tom: 2019, strony: 45301), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2019/9191328 - link to the publication
  2. Spectroscopic insights into the effect of pH, temperature, and stabilizer on erlotinib adsorption behavior onto Ag nanosurface
    Authors:
    N. Piergies, M. Oćwieja, C. Paluszkiewicz, W.M.Kwiatek
    Academic press:
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (rok: 2020, tom: 228, strony: 45299), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.saa.2019.117737 - link to the publication
  3. A physicochemical and spectroscopic characterization of novel erlotinib conjugates with platinum nanoparticles
    Authors:
    P. Gnacek, N. Piergies, D. Duraczyńska, M. Kozak, C. Paluszkiewicz, M. Oćwieja
    Academic press:
    Colloids and Surfaces A: Physicochemical and Engineering Aspects (rok: 2022, ), Wydawca: ELSEVIER
    Status:
    Accepted for publication
    DOI:
    10.1016/j.colsurfa.2022.130069 - link to the publication
  4. Nanoparticle stabilizer as a determining factor of the drug/gold surface interaction: SERS and AFM-SEIRA studies
    Authors:
    N. Piergies, M. Oćwieja, C. Paluszkiewicz, W.M. Kwiatek
    Academic press:
    Applied Surface Science (rok: 2021, tom: 537, strony: 45301), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.apsusc.2020.147897 - link to the publication
  5. IR nanospectroscopy to decipher drug/metal nanoparticle interactions: towards a better understanding of the spectral signal enhancement and its distribution
    Authors:
    N. Piergies, J. Mathurin, A. Dazzi, A. Deniset-Besseau, M. Oćwieja, C. Paluszkiewicz, W.M. Kwiatek
    Academic press:
    Applied Surface Science , Wydawca: ELSEVIER
    Status:
    Submitted
    DOI:
    brak - link to the publication
  6. Identification of erlotinib adsorption pattern onto silver nanoparticles: SERS studies
    Authors:
    N. Piergies, M. Oćwieja, C. Paluszkiewicz, W.M. Kwiatek
    Academic press:
    Journal of Raman Spectroscopy (rok: 2018, tom: 49, strony: 1065-1273), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jrs.5384 - link to the publication
  7. Monitoring the Interfacial Behavior of Selective Y5 Receptor Antagonist on Colloidal Gold Nanoparticle Surfaces: Surface-Enhanced Vibrational Spectroscopy Studies
    Authors:
    E. Pięta, N. Piergies, M. Oćwieja, H. Domin, C. Paluszkiewicz, E. Bielańska, W.M. Kwiatek
    Academic press:
    Journal Physical Chemistry C (rok: 2017, tom: 121, strony: 17276-17288), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcc.7b04435 - link to the publication
  8. Nanoscale image of the drug/metal mono-layer interaction: Tapping AFM-IR investigations
    Authors:
    N.Piergies, A. Dazzi, A. Deniset-Besseau, J. Mathurin, M. Oćwieja, C. Paluszkiewicz, W.M. Kwiatek
    Academic press:
    Nano Research (rok: 2020, tom: 13, strony: 1020-1028), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12274-020-2738-4 - link to the publication
  9. Polarization effect in tip-enhanced infrared nanospectroscopy studies of the selective Y5 receptor antagonist Lu AA33810
    Authors:
    N. Piergies, E. Pięta, C. Paluszkiewicz, H. Domin, W.M. Kwiatek
    Academic press:
    Nano Research (rok: 2018, tom: 11, strony: 4401-4411), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12274-018-2030-z - link to the publication
  1. Monitoring of the Adsorption Process of the Anticancer Drug Erlotinib Onto Potential Colloidal Nanocarriers
    Authors:
    N. Piergies, C. Paluszkiewicz, M. Oćwieja, W.M. Kwiatek
    Conference:
    LII Zakopane School of Physics (rok: 2017, ), Wydawca: IFJ PAN
    Data:
    konferencja 22.05 - 27.05. 2017 r.
    Status:
    Published
  2. A novel approach to characterize a drug-loaded nanoparticle system by means of IR nanospectroscopy
    Authors:
    N. Piergies , A. Dazzi, A. Deniset-Besseau, J. Mathurin , M. Oćwieja, C. Paluszkiewicz, W.M. Kwiatek
    Conference:
    11th International Conference on Advanced Vibrational Spectroscopy (ICAVS 11) (rok: 2021, ), Wydawca: Jagiellonian University in Krakow
    Data:
    konferencja 23.08 - 26.08.2021 r.
    Status:
    Published
  3. Temperature and Time - Dependent SERS Investigations: Insights Into the Drug - Nanocarrier Conjugates Stability
    Authors:
    N. Piergies, M. Oćwieja, C. Paluszkiewicz, W.M. Kwiatek
    Conference:
    XVth International Conference on Molecular spectroscopy (rok: 2019, ), Wydawca: Institute of Low Temperature and Structure Research of the Polish Academy of Sciences
    Data:
    konferencja 2019-09-15 - 2019-09-19
    Status:
    Published
  4. Adsorption Geometry Variations of the Anticancer Drug Onto Potential Colloidal Nanocarriers
    Authors:
    N. Piergies, C. Paluszkiewicz, M. Oćwieja, W.M. Kwiatek
    Conference:
    XIVth International Conference On Molecular Spectroscopy (rok: 2017, ), Wydawca: Wydawnictwo Naukowe "Akapit"
    Data:
    konferencja 03.09 - 07.09.2017r.
    Status:
    Published

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