Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Synthesis of 2-phosphonocarboxylates as potential covalent inhibitors of Rab geranylgeranyl transferase

2016/23/N/ST5/03230

Keywords:

Phosphonocarboxylates Geranylgeranylation Rab geranylgeranyl transferase covalent inhibitors

Descriptors:

  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Łódzka, Wydział Chemiczny

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Joanna Małolepsza 

Number of co-investigators in the project: 3

Call: PRELUDIUM 12 - announced on 2016-09-15

Amount awarded: 99 800 PLN

Project start date (Y-m-d): 2017-09-14

Project end date (Y-m-d): 2019-09-13

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Pompa próżniowa membranowa (17 835 PLN)
  2. Kolumna do HPLC, jonowymienna (7 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. Rational design, optimization, and biological evaluation of novel α-Phosphonopropionic acids as covalent inhibitors of Rab geranylgeranyl transferase
    Authors:
    Joanna Małolepsza, Aleksandra Marchwicka, Remigiusz A. Serwa, Sanna P. Niinivehmas, Olli T. Pentikäinen, Edyta Gendaszewska-Darmach, Katarzyna M. Błażewska
    Academic press:
    Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2022, tom: 37, strony: 940-951), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/14756366.2022.2053525 - link to the publication
  2. The McKenna reaction – avoiding side reactions in phosphonate deprotection
    Authors:
    Katarzyna Justyna, Joanna Małolepsza, Damian Kusy, Waldemar Maniukiewicz, Katarzyna M. Błażewska
    Academic press:
    Beilstein Journal of Organic Chemistry (rok: 2020, tom: 16, strony: 1436-1446), Wydawca: Beilstein Institut
    Status:
    Published
    DOI:
    10.3762/bjoc.16.119 - link to the publication

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