Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular mechanism of action and therapeutic effect of 5-aza-2'-deoxycytidine and topoisomerase inhibitors combination in treatment of colorectal cancer

2017/25/B/NZ5/02608

Keywords:

colorectal cancer 5-aza-2'-deoxycytidine topoisomerase inhibitor optical tweezers

Descriptors:

  • NZ5_7:
  • NZ5_9:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Wojciech Kałas 

Number of co-investigators in the project: 16

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 072 520 PLN

Project start date (Y-m-d): 2018-03-09

Project end date (Y-m-d): 2022-03-08

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. The Contrasting Delayed Effects of Transient Exposure of Colorectal Cancer Cells to Decitabine or Azacitidine
    Authors:
    Pawlak, Alicja, Kinga Chybicka, Ewa Zioło, Leon Strządała, and Wojciech Kałas
    Academic press:
    Cancers (Basel) (rok: 2022, tom: 14(6),, strony: 1530;), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers14061530 - link to the publication
  2. Profound Nanoscale Structural and Biomechanical Changes in DNA Helix upon Treatment with Anthracycline Drugs
    Authors:
    Aleksandra Kaczorowska, Weronika Lamperska, Kaja Frączkowska, Jan Masajada, Sławomir Drobczyński, Marta Sobas, Tomasz Wróbel, Kinga Chybicka, Radosław Tarkowski, Sebastian Kraszewski, Halina Podbielska, Wojciech Kałas, Marta Kopaczyńska
    Academic press:
    Int J Mol Sci (rok: 2020, tom: 21 (11), strony: 4142), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21114142 - link to the publication