Molecular mechanism of action and therapeutic effect of 5-aza-2'-deoxycytidine a

Molecular mechanism of action and therapeutic effect of 5-aza-2'-deoxycytidine and topoisomerase inhibitors combination in treatment of colorectal cancer

2017/25/B/NZ5/02608

Keywords

Descriptors

NZ5_7: Leczenie chorób człowieka
NZ5_9: Inne zagadnienia pokrewne

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Wojciech Kałas

Number of co-investigators in the project: 16

Call

OPUS 13 – announced on 2017-03-15

Amount awarded: 1 072 520 PLN
Project start date: 2018-03-09
Project end date: 2022-03-08
Project duration: 48 months (the same as in the proposal)
Project status: Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (2)

Profound Nanoscale Structural and Biomechanical Changes in DNA Helix upon Treatment with Anthracycline Drugs

Authors:
Aleksandra Kaczorowska, Weronika Lamperska, Kaja Frączkowska, Jan Masajada, Sławomir Drobczyński, Marta Sobas, Tomasz Wróbel, Kinga Chybicka, Radosław Tarkowski, Sebastian Kraszewski, Halina Podbielska, Wojciech Kałas, Marta Kopaczyńska

Academic press:
Int J Mol Sci (year: 2020, volume: 21 (11), pages: 4142), Publisher: MDPI

Status:
Published

DOI:
10.3390/ijms21114142 – link to the publication
The Contrasting Delayed Effects of Transient Exposure of Colorectal Cancer Cells to Decitabine or Azacitidine

Authors:
Pawlak, Alicja, Kinga Chybicka, Ewa Zioło, Leon Strządała, and Wojciech Kałas

Academic press:
Cancers (Basel) (year: 2022, volume: 14(6),, pages: 1530;), Publisher: MDPI

Status:
Published

DOI:
10.3390/cancers14061530 – link to the publication

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