Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Design, synthesis and biological evaluation of the new steroid sulfatase (STS) inhibitors based on sulfamate analogs containing C-F bonds

2015/19/N/NZ7/00938

Keywords:

steroid sulfatase breast cancer STS inhibitors

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ5_7: Human disease treatment
  • ST5_23:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Politechnika Gdańska, Wydział Chemiczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Mateusz Daśko 

Number of co-investigators in the project: 3

Call: PRELUDIUM 10 - announced on 2015-09-15

Amount awarded: 149 600 PLN

Project start date (Y-m-d): 2016-07-22

Project end date (Y-m-d): 2019-07-21

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Waga laboratoryjna (3 800 PLN)
  2. Wyparka obrotowa (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. New potent STS inhibitors based on fluorinated 4-(1-phenyl-1H-[1,2,3]triazol-4-yl)-phenyl sulfamates
    Authors:
    Daśko, M.; Demkowicz, S.; Rachon, J.; Biernacki, K.; Aszyk, J.; Kozak, W.; Masłyk, M.; Kubiński, K.
    Academic press:
    Journal of Asian Natural Products Research (rok: 2019, tom: brak, strony: brak), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/10286020.2019.1680642 - link to the publication
  2. Synthesis and biological evaluation of fluorinated N-benzoyl and N-phenylacetoyl derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as steroid sulfatase inhibitors
    Authors:
    Daśko M., Przybyłowska, M.; Rachon, J.; Masłyk, M.; Kubiński, K.; Misiak, M.; Składanowski, A.; Demkowicz, S.
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2017, tom: 128, strony: 79-87), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2017.01.028 - link to the publication
  3. Synthesis and biological evaluation of N-acylated tyramine sulfamates containing C-F bonds as steroid sulfatase inhibitors
    Authors:
    Daśko, M.; Rachon, J.; Masłyk, M.; Kubiński, K.; Demkowicz, S.
    Academic press:
    Chemical Biology & Drug Design (rok: 2017, tom: 90, strony: 156-161), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/cbdd.12931 - link to the publication
  4. Novel steroid sulfatase inhibitors based on N-thiophosphorylated 3-(4-aminophenyl)-coumarin-7-O-sulfamates
    Authors:
    Daśko, M.; Demkowicz, S.; Biernacki, K.; Harrous, A.; Rachon, J.; Kozak, W.; Martyna, A.; Masłyk, M.; Kubiński, K.; Boguszewska-Czubara, A.
    Academic press:
    Drug Development Research (rok: 2019, tom: brak, strony: brak), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/ddr.21569 - link to the publication
  5. Selected Methods for the Chemical Phosphorylation and Thiophosphorylation of Phenols
    Authors:
    Kozak, W.; Rachon, J.; Daśko, M.; Demkowicz, S.
    Academic press:
    Asian Journal of Organic Chemistry (rok: 2018, tom: 7, strony: 314-323), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/ajoc.201700638 - link to the publication

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