Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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EGFR and c-Met inhibitors as factors limiting formation of invadopodia in human melanoma cells

2014/15/B/NZ5/01467

Keywords:

melanoma invadopodia growth factors receptors inhibitors of growth factor receptors

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_5: Diagnostics in human diseases
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Dorota Nowak 

Number of co-investigators in the project: 4

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 634 940 PLN

Project start date (Y-m-d): 2015-07-22

Project end date (Y-m-d): 2019-07-21

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. system do elektroforezy białkowej i transferu białek metodą Western Blotting.
  2. Pojemnik do przechowywania próbek w ciekłym azocie (20 000 PLN)
  3. Zamrażarka niskotemperaturowa (51 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (4)
  1. Expression level of EGFR and MET receptors regulates invasiveness of melanoma cells
    Authors:
    Katarzyna Pietraszek-Gremplewicz, Aleksandra Simiczyjew, Ewelina Dratkiewicz, Marta Podgórska, Ilona Styczeń, Rafał Matkowski, Marcin Ziętek, Dorota Nowak
    Academic press:
    Journal of Cellular and Molecular Medicine (rok: 2019, tom: 23, strony: 8453–8463), Wydawca: Wiley-Blackwell
    Status:
    Published
    DOI:
    10.1111/jcmm.14730 - link to the publication
  2. Varying effects of EGF, HGF and TGFBeta on formation of invadopodia and invasiveness of melanoma cell lines of different origin.
    Authors:
    Makowiecka A., Simiczyjew A., Nowak D., Mazur A. J.
    Academic press:
    European Journal of Histochemistry (rok: 2016, tom: 60, strony: 230-238), Wydawca: PagePress
    Status:
    Published
    DOI:
    10.4081/ejh.2016.2728 - link to the publication
  3. Characterization of Melanoma Cell Lines Resistant to Vemurafenib and Evaluation of Their Responsiveness to EGFR- and MET-Inhibitor Treatment.
    Authors:
    Dratkiewicz Ewelina, Simiczyjew Aleksandra, Pietraszek-Gremplewicz Katarzyna, Mazurkiewicz Justyna, Nowak Dorota.
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 113), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21010113 - link to the publication
  4. Gefitinib or lapatinib with foretinib synergistically induce a cytotoxic effect in melanoma cell lines
    Authors:
    Ewelina Dratkiewicz, Katarzyna Pietraszek-Gremplewicz, Aleksandra Simiczyjew, Antonina Joanna Mazur, Dorota Nowak
    Academic press:
    Oncotarget (rok: 2018, tom: Vol.9 (No26), strony: 18254-18268), Wydawca: Impact Journal LLC
    Status:
    Published
    DOI:
    10.18632/oncotarget.24810 - link to the publication
  5. Combination of selected MET and EGFR inhibitors decreases melanoma cells' invasive abilities
    Authors:
    Aleksandra Simiczyjew, Katarzyna Pietraszek-Gremplewicz, Ewelina Dratkiewicz, Marta Podgórska, Rafał Matkowski, Marcin Ziętek, Dorota Nowak
    Academic press:
    Frontiers in Pharmacology (rok: 2019, tom: brak, strony: brak), Wydawca: Frontiers
    Status:
    Accepted for publication
    DOI:
    10.3389/fphar.2019.01116 - link to the publication
  1. Foretinib in combination with lapatinib orgefitinib reduces invasion of melanoma cells.
    Authors:
    Simiczyjew S., Pietraszek-Gremplewicz K., Dratkiewicz E., Podgóorska M., Matkowski R., Ziętek M., Nowak D.
    Conference:
    FEBS Congress (rok: 2019, ), Wydawca: FEBS press
    Data:
    konferencja 6-11.07.2019
    Status:
    Published
  2. Vemurafenib-resistant melanoma cells demonstrate altered invadopodia and changes in sensitivity to EGFR and c-Met inhibitors
    Authors:
    Dratkiewicz E., Simiczyjew A., Pietraszek-Gremplewicz K., Nowak D.
    Conference:
    Congress BIO2018 (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Data:
    konferencja 18-21.09.2018
    Status:
    Published
  3. Effect of EGFR and c-Met inhibitors on melanoma viability, cell cycle and migration
    Authors:
    Ewelina Dratkiewicz, Aleksandra Simiczyjew, Katarzyna Pietraszek-Gremplewicz, Dorota Nowak
    Conference:
    FEBS Advanced Lecture Course and European Cytoskeletal Forum Meeting / Cytoskeleton: Mechanical Coupling from the Plasma Membrane to Nucleus (rok: 2017, ), Wydawca: FEBS
    Data:
    konferencja 04-08.2017
    Status:
    Published
  4. Melanoma cells resistant to vemurafenib exhibited changes in expression profile of growth factor receptors and elevated invasive abilities.
    Authors:
    Dratkiewicz E., Simiczyjew A, Pietraszek-Gremplewicz K., Nowak D.
    Conference:
    FEBS Congress (rok: 2019, ), Wydawca: FEBS press
    Data:
    konferencja 6-11.07.2019
    Status:
    Published

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