Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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BET Bromodomain Inhibitors and improvement of glioblastoma therapy

2017/27/B/NZ5/02620

Keywords:

Bromodomain inhibitors nitric oxide glioblastoma photodynamic therapy

Descriptors:

  • NZ5_7: Human disease treatment
  • NZ1_2: Biochemistry
  • NZ3_7: Signal transduction

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Witold Korytowski 

Number of co-investigators in the project: 3

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 895 000 PLN

Project start date (Y-m-d): 2018-08-03

Project end date (Y-m-d): 2023-01-02

Project duration:: 53 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Aparat do PCR w czasie rzeczywistym (153 000 PLN)
  2. Inkubator CO2 (30 000 PLN)
  3. Pipetor Eppendorf.
  4. Zamrażarka głębokiego zamrażania -80oC (32 000 PLN)
  5. Mikroskop odwrócony fluorescencyjny Axio Observer 7ACR ze stolikiem skanującym STEP, stacją dokującą, komorą inkubacyjną i platformą antywibracyjną (420 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Negative effects of tumor cell nitric oxide on antiglioblastoma photodynamic therapy
    Authors:
    Albert W. Girotti, Jonathan M. Fahey and Witold Korytowski
    Academic press:
    . J Cancer Metastasis Treatment (rok: 2020, tom: 6, strony: 52-67), Wydawca: OAE Publishing Inc
    Status:
    Published
    DOI:
    10.20517/2394-4722.2020.107 - link to the publication
  2. Nitric Oxide Mediated Bystander Effect in Photodynamic Therapy
    Authors:
    J. Bazak, W. Korytowski, A. Girotti
    Academic press:
    Trends in Photochemistry and Photobiology (rok: 2019, tom: 18, strony: 59-67), Wydawca: Research Trends
    Status:
    Published
    DOI:
    Brak - link to the publication
  3. Upstream signaling events leading to elevated production of pro-survival nitric oxide in photodynamically-challenged glioblastoma cells
    Authors:
    Fahey, JM (Fahey, Jonathan M.) ; Korytowski, W (Korytowski, Witold) ; Girotti, AW (Girotti, Albert W.)
    Academic press:
    FREE RADICAL BIOLOGY AND MEDICINE (rok: 2019, tom: Volume: 137, strony: Pages: 37-45), Wydawca: ELSEVIER SCIENCE INC, STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2019.04.013 - link to the publication
  4. Bystander Effects of Nitric Oxide in Cellular Models of Anti-Tumor Photodynamic Therapy
    Authors:
    Bazak, Jerzy ; Korytowski, Witold ; Girotti, Albert W.
    Academic press:
    Cancers (rok: 2019, tom: 11, strony: ***), Wydawca: MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
    Status:
    Published
    DOI:
    10.3390/cancers11111674 - link to the publication
  5. Nitric oxide-elicited resistance to anti-glioblastoma photodynamic therapy
    Authors:
    Girotti, AW, Fahey, JM, and Korytowski, W.
    Academic press:
    Cancer Drug Resist. (rok: 2020, tom: 3, strony: 401-414), Wydawca: QAE Publishing Inc.
    Status:
    Published
    DOI:
    10.20517/cdr.2020.25 - link to the publication
  6. Role of nitric oxide in hyper-aggressiveness of tumor cells that survive various anti-cancer therapies
    Authors:
    AW Girotti, Jonathan F. Fahey and Witold Korytowski
    Academic press:
    Critical Reviews in Oncology/Hematology (rok: 2022, tom: 179, strony: 103805-103814), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.critrevonc.2022.103805 - link to the publication
  7. PRO-TUMOR BYSTANDER EFFECTS OF NITRIC OXIDE IN ANTI-TUMOR PHOTODYNAMIC THERAPY
    Authors:
    Girotti AW, Bazak J, Korytowski W.
    Academic press:
    Pharmaceutics (rok: 2023, tom: *, strony: *), Wydawca: MDPI
    Status:
    Submitted
    DOI:
    * - link to the publication

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