Projects funded by the NCN
Structure optimization of inhibitor for paracaspase MALT1
2013/11/N/ST5/01995
Keywords:
paracaspase MALT1 substrate specificty optimal inhibitor combinatorial chemistry
Descriptors:
- ST5_16:
- ST5_23:
Panel:
ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution :
Politechnika Wrocławska, Wydział Chemiczny
woj. dolnośląskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 6 - announced on 2013-09-16
Amount awarded: 100 000 PLN
Project start date (Y-m-d): 2014-10-01
Project end date (Y-m-d): 2016-09-30
Project duration:: 24 months (the same as in the proposal)
Project status: Project settled
Information in the final report
- Publication in academic press/journals (2)
- Book publications / chapters in book publications (1)
- Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probesAuthors:Paulina Kasperkiewicz, Sonia Kołt, Tomasz Janiszewski, Katarzyna Groborz, Marcin Poręba, Scott J. Snipas, Guy S. Salvesen, Marcin DrągAcademic press:Scientific Reports (rok: 2018, tom: 8, strony: Article number: 15998 (2018),), Wydawca: Nature publishing group, https://www.nature.com/articles/s41598-018-34476-7Status:PublishedDOI:10.1038/s41598-018-34476-7 - link to the publication
- Emerging challenges in the design of selective substrates, inhibitors and activity-based probes for indistinguishable proteases.Authors:Kasperkiewicz P, Poreba M, Groborz K, Drag MAcademic press:FEBS Journal (rok: 2017, tom: 284(10), strony: 1518-1539), Wydawca: WILEY-BLACKWELLStatus:PublishedDOI:10.1111/febs.14001 - link to the publication
- Screening Combinatorial Peptide Libraries in Protease Inhibitor Drug DiscoveryAuthors:Marcin Poreba, Paulina Kasperkiewicz, Wioletta Rut and Marcin DragBook:Extracellular Targeting of Cell Signaling in Cancer: Strategies Directed at MET and RON Receptor Tyrosine Kinase Pathways, (rok: 2018, tom: 1, strony: 307-350), Wydawca: John Wiley & Sons Ltd.Status:Published