Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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New inhibitors of catalytic subunit of telomerase.

2014/13/B/NZ7/02207

Keywords:

telomerase inhibitors anticancer compounds medicinal chemistry dibenzopyrrole derivatives

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • ST5_20:
  • NZ2_10: Biological systems analysis, modelling and simulation

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Politechnika Gdańska, Wydział Chemiczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maciej Bagiński 

Number of co-investigators in the project: 7

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 529 720 PLN

Project start date (Y-m-d): 2015-01-28

Project end date (Y-m-d): 2019-07-27

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputer PC (8 000 PLN)
  2. System do dokunentacji żeli (35 000 PLN)

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (3)
  1. Structural, functional, and stability change predictions in human telomerase upon specific point mutations
    Authors:
    U. Kalathiya, M. Padariya, M. Baginski
    Academic press:
    Scientific Reports (rok: 2019, tom: 6,42152777777778, strony: 45304), Wydawca: Nature Publishing group
    Status:
    Published
    DOI:
    10.1038/s41598-019-45206-y - link to the publication
  1. Molecular modeling and evaluation of dibenzopyrrole derivatives towards telomerase.
    Authors:
    M. Padariya, U. Kalathiya, M. Baginski
    Conference:
    EMBO Conference: Towards Novel Therapies: Emerging Insights from Structural and Molecular Biology, Groningen, The Netherlands (rok: 2017, ), Wydawca: EMBO, University of Groningen, The Netherlands
    Data:
    konferencja 42795
    Status:
    Published
  2. Structural analysis and predicting effects of natural mutations on telomerase.
    Authors:
    M. Padariya, U. Kalathiya, and M. Baginski
    Conference:
    24th Congress & General Assembly of the International Union of Crystallography 2017, Hyderabad, India (rok: 2017, ), Wydawca: International Union of Crystallography
    Data:
    konferencja 42948
    Status:
    Published
  3. Novel telomerase inhibitors for cancer therapy - in silico design and biological evaluation
    Authors:
    M. Padariya, U. Kalathiya, M. Wysocka, K. Szwarc, M. Serocki, A. Skladanowski, M. Baginski
    Conference:
    2015 International Chemical Congress of Pacific Basin Societies (rok: 2015, ), Wydawca: PacifiChem
    Data:
    konferencja 15-20 grudzień 2015
    Status:
    Published
    DOI:
    link to the publication

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