New inhibitors of catalytic subunit of telomerase.
2014/13/B/NZ7/02207
Keywords
Descriptors
- NZ7_14: Farmacja, farmakoterapia, farmakologia
- ST5_20: Chemia pojedynczych cząsteczek i makrocząsteczek
- NZ2_10: Modelowanie i symulacje biologiczne
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Politechnika Gdańska, Wydział Chemiczny
Voivodeship: pomorskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 7
Call
OPUS 7 – announced on 2014-03-17
- Amount awarded
- 529 720 PLN
- Project start date
- 2015-01-28
- Project end date
- 2019-07-27
- Project duration
- 54 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Komputer PC. Cost: 8 000 PLN
- System do dokunentacji żeli. Cost: 35 000 PLN
Information in the final report
Publication in academic press/journals (1)
-
Structural, functional, and stability change predictions in human telomerase upon specific point mutations
- Authors:
- U. Kalathiya, M. Padariya, M. Baginski
- Academic press:
- Scientific Reports (year: 2019, volume: 6,42152777777778, pages: 46035), Publisher: Nature Publishing group
- Status:
- Published
- DOI:
- 10.1038/s41598-019-45206-y – link to the publication
Articles in post-conference publications (3)
-
Structural analysis and predicting effects of natural mutations on telomerase.
- Authors:
- M. Padariya, U. Kalathiya, and M. Baginski
- Conference:
- 24th Congress & General Assembly of the International Union of Crystallography 2017, Hyderabad, India (year: 2017, pages: Book of abstracts poster 2059), Publisher: International Union of Crystallography
- Date:
- conference 42948
- Status:
- Published
-
Molecular modeling and evaluation of dibenzopyrrole derivatives towards telomerase.
- Authors:
- M. Padariya, U. Kalathiya, M. Baginski
- Conference:
- EMBO Conference: Towards Novel Therapies: Emerging Insights from Structural and Molecular Biology, Groningen, The Netherlands (year: 2017, pages: Book of abstracts poster 32), Publisher: EMBO, University of Groningen, The Netherlands
- Date:
- conference 42795
- Status:
- Published
-
Novel telomerase inhibitors for cancer therapy - in silico design and biological evaluation
- Authors:
- M. Padariya, U. Kalathiya, M. Wysocka, K. Szwarc, M. Serocki, A. Skladanowski, M. Baginski
- Conference:
- 2015 International Chemical Congress of Pacific Basin Societies (year: 2015, pages: 294-TECH, Abstract 449), Publisher: PacifiChem
- Date:
- conference 15-20 grudzień 2015
- Status:
- Published
- DOI:
- link to the publication