Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Sensitization of cancer cells to chemotherapy by novel DNA repair inhibitors

2013/11/B/NZ7/01340

Keywords:

DNA repair inhibitors of DNA repair chemotherapy

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Tomasz Popławski 

Number of co-investigators in the project: 5

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 280 000 PLN

Project start date (Y-m-d): 2014-07-30

Project end date (Y-m-d): 2017-07-29

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Wirówka z chłodzeniem (20 000 PLN)
  2. Inkubator CO2.

Information in the final report

  • Publication in academic press/journals (4)
  1. DNA double-strand breaks repair inhibitors potentiates the combined effect of VP-16 and CDDP in human colorectal adenocarcinoma (LoVo) cells
    Authors:
    Paulina Kopa, Anna Macieja, Elzbieta Pastwa, Ireneusz Majsterek, Tomasz Poplawski
    Academic press:
    Molecular Biology Reports (rok: 2021, tom: Online, strony: 45303), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11033-020-06124-9 - link to the publication
  2. Comparison of the effect of three different topoisomerase II inhibitors combined with cisplatin in human glioblastoma cells sensitized with double strand break repair inhibitors
    Authors:
    Anna Macieja, Paulina Kopa, Grzegorz Galita, Elżbieta Pastwa, Ireneusz Majsterek,Tomasz Poplawski
    Academic press:
    Molecular Biology Reports (rok: 2019, tom: 46, strony: 3625–3636), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11033-019-04605-0 - link to the publication
  3. Inhibition of DNA‑PK potentiates the synergistic effect of NK314 and etoposide combination on human glioblastoma cells
    Authors:
    Paulina Kopa, Anna Macieja, Izabela Gulbas, Elzbieta Pastwa, Tomasz Poplawski
    Academic press:
    Molecular Biology Reports (rok: 2019, tom: 47, strony: 67-76), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11033-019-05105-x - link to the publication
  4. DNA Double Strand Breaks Repair Inhibitors: Relevance as Potential New Anticancer Therapeutics
    Authors:
    Paulina Kopa, Anna Macieja, Grzegorz Galita, Zbigniew J. Witczak and Tomasz Poplawski
    Academic press:
    Current Medicinal Chemistry (rok: 2018, tom: 25, strony: 45302), Wydawca: Benthamscience
    Status:
    Published
    DOI:
    10.2174/0929867325666180214113154 - link to the publication

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