Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Novel human topoisomerase II inhibitors as anticancer agents

2018/29/N/NZ7/01726

Keywords:

molecular modeling thiosemicarbazide derivatives type II topoisomerase inhibitors anticancer activity

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_15: Toxicology
  • NZ5_7: Human disease treatment

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Nauk o Zdrowiu

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Barbara Kaproń 

Number of co-investigators in the project: 3

Call: PRELUDIUM 15 - announced on 2018-03-15

Amount awarded: 209 558 PLN

Project start date (Y-m-d): 2019-04-12

Project end date (Y-m-d): 2023-04-11

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Laptop (5 000 PLN)
  2. Lodówka (3 700 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. Identification of the first-in-class dual inhibitors of human DNA topoisomerase IIα and indoleamine-2,3-dioxygenase 1 (IDO 1) with strong anticancer properties
    Authors:
    Barbara Kaproń, Anita Płazińska, Wojciech Płaziński, Tomasz Plech
    Academic press:
    Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2023, tom: 38, strony: 192-202), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1080/14756366.2022.2140420 - link to the publication
  2. Thiosemicarbazide Derivatives Targeting Human TopoII α and IDO-1 as Small-Molecule Drug Candidates for Breast Cancer Treatment
    Authors:
    Barbara Kaproń, Robert Czarnomysy, Dominika Radomska, Krzysztof Bielawski, Tomasz Plech
    Academic press:
    International journal of Molecular Sciences (rok: 2023, tom: 24, strony: 5812), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24065812 - link to the publication

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