Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Novel human topoisomerase II inhibitors as anticancer agents

2018/29/N/NZ7/01726

Keywords:

molecular modeling thiosemicarbazide derivatives type II topoisomerase inhibitors anticancer activity

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_15: Toxicology
  • NZ5_7: Human disease treatment

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Nauk o Zdrowiu

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Barbara Kaproń 

Number of co-investigators in the project: 3

Call: PRELUDIUM 15 - announced on 2018-03-15

Amount awarded: 209 558 PLN

Project start date (Y-m-d): 2019-04-12

Project end date (Y-m-d): 2023-04-11

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Laptop (5 000 PLN)
  2. Lodówka (3 700 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. Thiosemicarbazide Derivatives Targeting Human TopoII α and IDO-1 as Small-Molecule Drug Candidates for Breast Cancer Treatment
    Authors:
    Barbara Kaproń, Robert Czarnomysy, Dominika Radomska, Krzysztof Bielawski, Tomasz Plech
    Academic press:
    International journal of Molecular Sciences (rok: 2023, tom: 24, strony: 5812), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24065812 - link to the publication
  2. Identification of the first-in-class dual inhibitors of human DNA topoisomerase IIα and indoleamine-2,3-dioxygenase 1 (IDO 1) with strong anticancer properties
    Authors:
    Barbara Kaproń, Anita Płazińska, Wojciech Płaziński, Tomasz Plech
    Academic press:
    Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2023, tom: 38, strony: 192-202), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.1080/14756366.2022.2140420 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy