Projects funded by the NCN
The role of DNA methylation in enhancing the sensitivity of colorectal cancer cells to topoisomerase inhibitors.
2015/17/N/NZ3/03737
Keywords:
colorectal cancer DNA methylation chemosensitivity epigenetic drugs combination therapy topoisomerase inhibitors LINE-1
Descriptors:
- NZ3_1: Cell biology
- NZ2_1: Molecular genetics
- NZ5_7: Human disease treatment
Panel:
NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology
Host institution :
Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN
woj. dolnośląskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 9 - announced on 2015-03-16
Amount awarded: 150 000 PLN
Project start date (Y-m-d): 2016-01-26
Project end date (Y-m-d): 2018-02-25
Project duration:: 25 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- Long-lasting reduction in clonogenic potential of colorectal cancer cells by sequential treatments with 5-azanucleosides and topoisomerase inhibitors.Authors:Alicja Pawlak, Ewa Ziolo, Anna Fiedorowicz, Klaudyna Fidyt, Leon Strzadala, Wojciech KalasAcademic press:BMC Cancer (rok: 2016, tom: 1,28680555555556, strony: 45304), Wydawca: BioMed CentralStatus:PublishedDOI:10.1186/s12885-016-2925-6 - link to the publication