Projects funded by the NCN


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418 projects found matching your search criteria :

  1. Restoration of beta-cell function via inhibition of diabetic kinome.

    Call: SONATA BIS 9 , Panel: NZ1

    Principal investigator: dr Anna Czarna

    Uniwersytet Jagielloński

  2. Molecular mechanisms, signal transduction and inhibition of PEBP1-15LOX protein complex triggering the ferroptotic cell ...

    Call: SONATA 15 , Panel: ST4

    Principal investigator: dr hab. Karolina Anna Mikulska-Rumińska

    Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Fizyki, Astronomii i Informatyki Stosowanej

  3. Development of a three-dimensional in vitro model for studying the mechanisms of immunostimulatory activity of PD-1/PD-L...

    Call: PRELUDIUM 18 , Panel: NZ5

    Principal investigator: Justyna Natalia Kocik-Król

    Uniwersytet Jagielloński, Wydział Chemii

  4. Modulation of ATP production using glycolysis inhibitors in cancer cells monitored by novel biosensing systems based on ...

    Call: PRELUDIUM 19 , Panel: ST4

    Principal investigator: Katarzyna Cecylia Ratajczak

    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Biologii

  5. Changes in lipid metabolism of resistant to BRAF/MEK inhibitors human melanoma cells associated with the presence of adi...

    Call: SONATA 16 , Panel: NZ5

    Principal investigator: dr Aleksandra Simiczyjew

    Uniwersytet Wrocławski, Wydział Biotechnologii

  6. Synthesis and evaluation of PD-L1 inhibitors based on mixed mode scaffolds containing amino acid derivatives, short pept...

    Call: SONATA 16 , Panel: ST4

    Principal investigator: dr Ewa Maria Surmiak

    Uniwersytet Jagielloński, Wydział Chemii

  7. Cell-based high-throughput screening for small-molecule compounds diminishing molecular markers of pathogenesis in myoto...

    Call: OPUS 20 , Panel: NZ3

    Principal investigator: dr hab. Marzena Wojciechowska

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  8. The role of somatostatin- and parvalbumin interneurons in the modulation of neuronal function and synaptic plasticity vi...

    Call: OPUS 20 , Panel: NZ4

    Principal investigator: dr hab. Joanna Małgorzata Urban-Ciećko

    Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

  9. Heterocyclization of benzenoid ansamycins core as useful strategy for designing anticancer agents

    Call: PRELUDIUM 20 , Panel: ST4

    Principal investigator: Natalia Anna Skrzypczak

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

  10. Targeting of HSF1 as a therapeutic approach to inhibit the progression of hormone-dependent breast cancer.

    Call: OPUS 22 , Panel: NZ5

    Principal investigator: dr Natalia Vydra

    Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Oddział w Gliwicach

  11. Small-molecule inhibitors of protein aggregation and ER stress as a novel strategy against neurodegeneration in the cour...

    Call: PRELUDIUM BIS 3 , Panel: NZ5

    Principal investigator: prof. Ireneusz Jacek Majsterek

    Uniwersytet Medyczny w Łodzi

  12. Covalent inhibiors of bacterial ureases - design, activity and mode of binding

    Call: PRELUDIUM 9 , Panel: NZ1

    Principal investigator: dr Katarzyna Macegoniuk

    Politechnika Wrocławska, Wydział Chemiczny

  13. Protein and gene expression analysis in the course of renal cancer stem-like cells' primary resistance to sorafenib in h...

    Call: PRELUDIUM 9 , Panel: NZ5

    Principal investigator: Zofia Bielecka

    Wojskowy Instytut Medyczny

  14. New approach in bisubstrate analogs inhibitors designing.

    Call: PRELUDIUM 9 , Panel: NZ1

    Principal investigator: dr Maria Winiewska-Szajewska

    Instytut Biochemii i Biofizyki PAN

  15. Insight into biochemistry, structure, evolution and biology of bacterial serpins on example of miropin from human pathog...

    Call: OPUS 9 , Panel: NZ1

    Principal investigator: dr Mirosław Książek

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  16. The role of DNA methylation in enhancing the sensitivity of colorectal cancer cells to topoisomerase inhibitors.

    Call: PRELUDIUM 9 , Panel: NZ3

    Principal investigator: Alicja Pawlak

    Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN

  17. Quantitative model for predicting CYP inhibition parameters for novel arylpiperazine derivatives.

    Call: PRELUDIUM 9 , Panel: NZ7

    Principal investigator: dr Szymon Ulenberg

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

  18. Using X-ray crystallography for localization of the sites of binding of allosteric inhibitors and activators within the ...

    Call: PRELUDIUM 9 , Panel: NZ1

    Principal investigator: Julia Witkowska

    Uniwersytet Gdański, Wydział Chemii

  19. Chemical syntesis and evaluation of biochemical properties of 7-methyloguanosine 5'-diphosphate analogs as inhibitors of...

    Call: PRELUDIUM 1 , Panel: NZ1

    Principal investigator: Marcin Ziemniak

    Uniwersytet Warszawski, Wydział Fizyki

  20. Study of casein kinase CK2 inhibition mechanisms

    Call: OPUS 1 , Panel: ST5

    Principal investigator: prof. Maria Bretner

    Politechnika Warszawska, Wydział Chemiczny, Wydział Chemiczny

  21. Crystallography of DNA repair enzymes as a tool to study substrate specifity and a mechanism of inhibition

    Call: HARMONIA 1 , Panel: NZ1

    Principal investigator: prof. Barbara Tudek

    Instytut Biochemii i Biofizyki PAN

  22. Design and synthesis of new rifampicin analogs as a source of effective bacterial RNA polymerase inhibitors

    Call: OPUS 2 , Panel: ST5

    Principal investigator: dr hab. Piotr Przybylski

    Uniwersytet im. Adama Mickiewicza, Wydział Chemii

  23. Design, synthesis and biological evaluation of Steroid Sulfatase Inhibitors based on organophosphorus compounds.

    Call: SONATA 2 , Panel: NZ7

    Principal investigator: dr Sebastian Demkowicz

    POLITECHNIKA GDAŃSKA

  24. Hydrogen exchange mass spectrometry (HXMS) for studying human serum amyloid A fibril formation.

    Call: PRELUDIUM 2 , Panel: NZ5

    Principal investigator: Marta Sosnowska

    Uniwersytet Gdański, Wydział Chemii

  25. Identification of key structural elements of immunomodulatory proteins - inhibitors of antigenic peptide transporter TAP...

    Call: SONATA 18 , Panel: NZ7

    Principal investigator: dr Natalia Karska

    Uniwersytet Gdański, Wydział Chemii

  26. Targeted inhibition of hypusination pathway

    Call: OPUS 24 , Panel: NZ7

    Principal investigator: dr Przemysław Grudnik

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  27. Development of a cell-based assay for screening of SARS-CoV-2 PLpro inhibitors

    Call: SONATA 18 , Panel: NZ6

    Principal investigator: dr Wioletta Katarzyna Rut

    Politechnika Wrocławska

  28. Development of novel anti-cancer immunotherapy against mesothelioma comprising of oncolytic adenovirus vectors armed wit...

    Call: SONATA 18 , Panel: NZ7

    Principal investigator: dr Łukasz Kuryk

    Narodowy Instytut Zdrowia Publicznego PZH - Państwowy Instytut Badawczy

  29. Designing Active Inhibitors of SARS-CoV-2 Methyltransferases

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Alex Jun Matsuda

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  30. Computational alchemy and experimental validation: a hybrid approach for designing new antimicrobial peptides

    Call: PRELUDIUM 22 , Panel: NZ1

    Principal investigator: Piotr Maciej Chyży

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  31. Understanding the contribution of immunoproteasome activation to the neuropathic pain development.

    Call: OPUS 25 , Panel: NZ7

    Principal investigator: dr Natalia Małek-Chudzik

    Politechnika Wrocławska

  32. Investigating the mechanisms of CD20 downregulation triggered by tyrosine kinase inhibitors in Philadelphia chromosome-p...

    Call: PRELUDIUM 22 , Panel: NZ5

    Principal investigator: Krzysztof Domka

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  33. Theoretical prediction, chemical synthesis and biological analysis of a novel class of HSPA5 inhibitors

    Call: OPUS 25 , Panel: ST4

    Principal investigator: prof. Arkadiusz Chworoś

    Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

  34. Modulation of the N-glycosylation as a tool to improve the CAR-T immunotherapy efficacy

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr Agnieszka Graczyk-Jarzynka

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  35. Restoring Beta-cell Integrity through Targeted SPOP Inhibition and PDX-1 Preservation

    Call: OPUS 26 (LAP) , Panel: NZ7

    Principal investigator: dr Anna Czarna

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  36. Selective inhibition of Janus kinases for the treatment of autoimmune hepatitis: Translational PK/PD modelling from mole...

    Call: SONATA 19 , Panel: NZ7

    Principal investigator: dr Artur Świerczek

    Uniwersytet Jagielloński, Collegium Medicum

  37. Development and characterization of novel multitargeted organometallic tubulin polymerization inhibitors for enhancing t...

    Call: OPUS 27 , Panel: NZ7

    Principal investigator: dr hab. Damian Plażuk

    Uniwersytet Łódzki

  38. Analysis of pharmacokinetic, pharmacodynamic and molecular determinants of intolerance and resistance to the Janus kinas...

    Call: OPUS 27 , Panel: NZ7

    Principal investigator: dr hab. Marta Karaźniewicz-Łada

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  39. Zika virus NS3 protease

    Call: OPUS 11 , Panel: NZ6

    Principal investigator: dr hab. Krzysztof Pyrć

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  40. Precision medicine-guided synthetic lethality targeting DNA repair to eradicate solid tumors

    Call: HARMONIA 8 , Panel: NZ7

    Principal investigator: dr hab. Tomasz Śliwiński

    UNIWERSYTET ŁÓDZKI, Wydział Biologii i Ochrony Środowiska

  41. The role of arginase-1 in antitumor efficacy of cancer immunotherapy using checkpoint inhibitors

    Call: OPUS 12 , Panel: NZ6

    Principal investigator: prof. Dominika Nowis

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  42. Evaluation of SLC22A5 activity modulation in sensitizing glioma cells to the suppression of fatty acid oxidation by CPT1...

    Call: PRELUDIUM 12 , Panel: NZ3

    Principal investigator: Barbara Juraszek

    Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

  43. Role of FMRP protein in the regulation of BRCA1 translation in leukemia cells.

    Call: PRELUDIUM 12 , Panel: NZ3

    Principal investigator: Magdalena Wołczyk

    Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

  44. Serum PAD-activity: Risk Factor in Development and Novel Biomarker in Rheumatoid Arthritis

    Call: OPUS 12 , Panel: NZ5

    Principal investigator: dr hab. Piotr Mydel

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  45. Synthesis of 2-phosphonocarboxylates as potential covalent inhibitors of Rab geranylgeranyl transferase

    Call: PRELUDIUM 12 , Panel: ST5

    Principal investigator: Joanna Małolepsza

    Politechnika Łódzka, Wydział Chemiczny

  46. The role of inhibition in semantic processing in a within-language and between-language context: event-related potential...

    Call: OPUS 13 , Panel: HS6

    Principal investigator: dr Karolina Rataj

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Anglistyki

  47. Anilide derivatives of long-chain cyclic amines as multifunctional serotonin receptors ligands and phosphodiesterase 7 i...

    Call: PRELUDIUM 13 , Panel: NZ7

    Principal investigator: dr Agnieszka Jankowska

    Uniwersytet Jagielloński – Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  48. Pharmacologial protection of transplant kidneys from ischemia/reperfusion injury- animal model study ex vivo i in vivo

    Call: OPUS 14 , Panel: NZ4

    Principal investigator: prof. Grzegorz Sawicki

    Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny

  49. Investigation of the effect of thiol group and urea bond on the peptidomimetics' affinity to receptors associated with a...

    Call: PRELUDIUM 14 , Panel: NZ7

    Principal investigator: dr Anna Puszko

    Uniwersytet Warszawski, Wydział Chemii

  50. The influence of perinatal exposure to selective serotonin reuptake inhibitors on the structure and functions of mice do...

    Call: OPUS 14 , Panel: NZ4

    Principal investigator: prof. Grzegorz Hess

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk