Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Studies on mechanisms of GABAergic plasticity in the interneurons and pyramidal cells in mouse hippocampus

2018/31/B/NZ4/01998

Keywords:

GABAergic Interneurons LTP integrins inhibitory postsynaptic current dopamine

Descriptors:

  • NZ3_6:
  • NZ3_2:
  • NZ4_7:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Lekarski

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jerzy Władysław Mozrzymas 

Number of co-investigators in the project: 7

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 887 600 PLN

Project start date (Y-m-d): 2019-09-03

Project end date (Y-m-d): 2023-09-02

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (10)
  • Articles in post-conference publications (7)
  1. Induction of Inhibitory Synaptic Plasticity Enhances Tonic Current by Increasing the Content of α5-Subunit Containing GABAA Receptors in Hippocampal Pyramidal Neurons
    Authors:
    Marcin Wyroślak, Katarzyna Lebida, Jerzy W Mozrzymas
    Academic press:
    Neuroscience (rok: 2021, tom: 467, strony: 39-46), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2021.05.020 - link to the publication
  2. Somatostatin and somatostatin containing interneurons - from plasticity to pathology.
    Authors:
    Monika Liguz-Lęcznar, Grzegorz Dobrzański, Małgorzata Kossut
    Academic press:
    Biomolecules (rok: 2022, tom: 12, strony: 312), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom12020312 - link to the publication
  3. Integrins bidirectionally regulate the efficacy of inhibitory synaptic transmission and control GABAergic plasticity
    Authors:
    Grzegorz Wiera, Patrycja Brzdąk, Anna Lech, Katarzyna Lebida, Jadwiga Jablonska, Przemyslaw Gmerek, and Jerzy Mozrzymas
    Academic press:
    Journal of Neuroscience (rok: 2022, tom: 42 (30), strony: 5830-5842), Wydawca: Society for Neuroscience
    Status:
    Published
    DOI:
    10.1523/JNEUROSCI.1458-21.2022 - link to the publication
  4. Extracellular Metalloproteinases in the Plasticity of Excitatory and Inhibitory Synapses
    Authors:
    Grzegorz Wiera Jerzy W. Mozrzymas
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 2055 (1-25)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10082055 - link to the publication
  5. GABAergic synapses onto SST and PV interneurons in the CA1 hippocampal region show cell-specific and integrin-dependent plasticity
    Authors:
    Patrycja Brzdąk , Katarzyna Lebida , Marcin Wyroślak Jerzy W Mozrzymas
    Academic press:
    Scientific reports (rok: 2023, tom: 13(1), strony: 5079), Wydawca: Springer Nature Group
    Status:
    Published
    DOI:
    10.1038/s41598-023-31882-4 - link to the publication
  6. Induction of Inhibitory Synaptic Plasticity Enhances Tonic Current by Increasing the Content of α5-Subunit Containing GABAA Receptors in Hippocampal Pyramidal Neurons
    Authors:
    Marcin Wyroślak, Katarzyna Lebida, Jerzy W Mozrzymas
    Academic press:
    Neuroscience (rok: 2021, tom: 467, strony: 39-46), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2021.05.020 - link to the publication
  7. Integrins bidirectionally regulate the efficacy of inhibitory synaptic transmission and control GABAergic plasticity
    Authors:
    Grzegorz Wiera, Patrycja Brzdąk, Anna Lech, Katarzyna Lebida, Jadwiga Jablonska, Przemyslaw Gmerek, and Jerzy Mozrzymas
    Academic press:
    Journal of Neuroscience (rok: 2022, tom: 42 (30), strony: 5830-5842), Wydawca: Society for Neuroscience
    Status:
    Published
    DOI:
    10.1523/JNEUROSCI.1458-21.2022 - link to the publication
  8. Long‑term plasticity of inhibitory synapses in the hippocampus and spatial learning depends on matrix metalloproteinase 3
    Authors:
    Grzegorz Wiera, Katarzyna Lebida, Anna Maria Lech, Patrycja Brzdąk, Inge Van Hove, Lies De Groef, Lieve Moons, Enrica Maria Petrini, Andrea Barberis, Jerzy W. Mozrzymas
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2021, tom: 78, strony: 2279-2298), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-020-03640-6 - link to the publication
  9. Bidirectional plasticity of GABAergic tonic inhibition in hippocampal somatostatin- and parvalbumin-containing interneurons
    Authors:
    Marcin Wyroślak, Grzegorz Dobrzański, Jerzy W. Mozrzymas
    Academic press:
    Frontiers in Cellular Neuroscience (rok: 2023, tom: 17, strony: 1193383), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fncel.2023.1193383 - link to the publication
  10. GABAergic synapses onto SST and PV interneurons in the CA1 hippocampal region show cell-specific and integrin-dependent plasticity
    Authors:
    Patrycja Brzdąk , Katarzyna Lebida , Marcin Wyroślak Jerzy W Mozrzymas
    Academic press:
    Scientific reports (rok: 2023, tom: 13(1), strony: 5079), Wydawca: Springer Nature Group
    Status:
    Published
    DOI:
    10.1038/s41598-023-31882-4 - link to the publication
  1. MUTATIONS OF BETA2 H267 RESIDUE OF GABAA RECEPTOR TRANSMEMBRANE DOMAIN AFFECT GATING TRANSITIONS DURING RECEPTOR ACTIVATION
    Authors:
    Marta M. Czyżewska*, Katarzyna Terejko, Michał A. Michałowski, Marcin Wyroślak, Jerzy W. Mozrzymas
    Conference:
    NEURONUS 2022-NEUROSCIENCE FORUM SUPPORTED BY IBRO (rok: 2022, ), Wydawca: Uniwersytet Jagielloński
    Data:
    konferencja 15-17.10.2022
    Status:
    Published
  2. GABAergic tonic inhibition shows cell type-dependent plasticity in the hippocampus.
    Authors:
    Marcin Wyroślak, Jerzy W. Mozrzymas
    Conference:
    NEURONUS 2020 IBRO NEUROSCIENCE FORUM (rok: 2020, ), Wydawca: Uniwersytet Jagielloński
    Data:
    konferencja 8-11.12.2020
    Status:
    Published
  3. DISTINCT REGULATION OF GABAERGIC TRANSMISSION AND PLASTICITY ONTO INTERNEURONS IN THE CA1 REGION OF HIPPOCAMPUS – ROLE OF INTEGRINS
    Authors:
    Patrycja Brzdąk, Katarzyna Lebida#, Jerzy W. Mozrzymas
    Conference:
    NEURONUS 2022-NEUROSCIENCE FORUM SUPPORTED BY IBRO (rok: 2022, ), Wydawca: Uniwersytet Jagielloński
    Data:
    konferencja 15-17.10.2022
    Status:
    Published
  4. Function and plasticity of GABAergic transmission
    Authors:
    Jerzy W. Mozrzymas, Grzegorz Wiera, Katarzyna Lebida, Patrycja Brzdąk, Jadwiga Jabłońska, Anna Lech, Marcin Wyroślak, Przemysław Gmerek
    Conference:
    5th Congress of Polish Biosciences BIO2023 (rok: 2023, ), Wydawca: nie dotyczy
    Data:
    konferencja 13-16.09.2023
    Status:
    Published
  5. Function and plasticity of GABAergic transmission
    Authors:
    Jerzy W. Mozrzymas, Grzegorz Wiera, Katarzyna Lebida, Patrycja Brzdąk, Jadwiga Jabłońska, Anna Lech, Marcin Wyroślak, Przemysław Gmerek
    Conference:
    5th Congress of Polish Biosciences BIO2023 (rok: 2023, ), Wydawca: nie dotyczy
    Data:
    konferencja 13-16.09.2023
    Status:
    Published
  6. Involvement of integrins in regulation of hippocampal GABAergic synaptic transmission and plasticity in the CA1 region.
    Authors:
    Katarzyna Lebida, Patrycja Brzdąk, Jerzy W. Mozrzymas
    Conference:
    NEURONUS 2020 IBRO NEUROSCIENCE FORUM (rok: 2020, ), Wydawca: Uniwersytet Jagielloński
    Data:
    konferencja 8-11.12.2020
    Status:
    Published
  7. Plasticyty of inhibitory synapses in the hippocampus
    Authors:
    J.W. Mozrzymas, G. Wiera, P. Brzdąk, J. Jabłońska, A. Lech, M. Wyroślak, P. Gmerek
    Conference:
    29 Congress of the Polish Physiological Society (rok: 2023, ), Wydawca: Polskie Towarzystwo Fizjologiczne
    Data:
    konferencja 21-23.09.2023
    Status:
    Published

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