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Gold and silver nanoparticles as carriers for delivery of 5' end mRNA cap analogues with potential therapeutical application

2018/31/B/ST5/03544

Keywords

Descriptors

  • ST5_23: Chemia organiczna
  • ST5_10: Nanomateriały: nanocząstki, nanorurki
  • ST5_16: Chemia biologiczna

Panel

ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution

Uniwersytet Warszawski, Wydział Chemii

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Marzena Jankowska-Anyszka

Number of co-investigators in the project: 10

Call

OPUS 16 – announced on 2018-09-14

Amount awarded
1 367 900 PLN
Project start date
2019-07-24
Project end date
2024-07-23
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (8)

  1. The potential of N2-modified cap analogues for precise genetic manipulation through mRNA engineering

    Authors:
    Karol Kurpiejewski, Anna Stankiewicz-Drogon, Karolina Piecyk, Eliza Rajkowska, Paulina Skrzypczyk , Jingping Geng, Edward Darzynkiewicz, Renata Grzela, Marzena Jankowska-Anyszka
    Academic press:
    Frontiers in Molecular Biosciences (year: 2024, volume: 10, pages: 46032), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmolb.2023.1269028 – link to the publication

  2. N2 modified cap analogues as translation inhibitors and substrates for preparation of therapeutic mRNA

    Authors:
    Karol Kurpiejewski, Marzena Jankowska-Anyszka, Renata Grzela
    Academic press:
    European Biophysics Journal (year: 2023, volume: 52, pages: 511-519), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00249-023-01676-7 – link to the publication

  3. The Synergistic Effect of N2 and N7 Modifications on the Inhibitory Efficacy of mRNA Cap Analogues

    Authors:
    Karol Kurpiejewski, Karolina Piecyk, Maciej Lukaszewicz, Karol Kamel,, Kazimierz Chmurski; Sebastian Kmiecik Marzena Jankowska-Anyszka
    Academic press:
    Pharmaceuticals (year: 2024, volume: 17, pages: 632-646), Publisher: MPDI
    Status:
    Published
    DOI:
    10.3390/ph17050632 – link to the publication

  4. Isoxazole-containing 5′ mRNA cap analogues as inhibitors of the translation initiation process

    Authors:
    Karolina Piecyk, Maciej Łukaszewicz, Karol Kamel, Maria Janowska, Paulina Pietrow, Sebastian Kmiecik, Marzena Jankowska-Anyszka
    Academic press:
    Bioorganic Chemistry (year: 2020, volume: 96, pages: 103583), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2020.103583 – link to the publication

  5. N2 modified dinucleotide cap analogs as a potent tool for mRNA engineering

    Authors:
    Renata Grzela, Karolina Piecyk, Anna Stankiewicz-Drogon, Paulina Pietrow, Maciej Lukaszewicz, Karol Kurpiejewski, Edward Darzynkiewicz, Marzena Jankowska-Anyszka
    Academic press:
    RNA (year: 2023, volume: 29(2), pages: 200-216), Publisher: Cold Spring Harbor Laboratory Press
    Status:
    Published
    DOI:
    10.1261/rna.079460.122 – link to the publication

  6. Decapping Scavenger Enzyme Activity toward N2-Substituted 5′ End mRNA Cap Analogues

    Authors:
    Paulina Pietrow, Aleksandra Ferenc-Mrozek, Karolina Piecyk, Elżbieta Bojarska, Edward Darżynkiewicz, Marzena Jankowska-Anyszka
    Academic press:
    ACS Omega (year: 2019, volume: 4, pages: 17576-17580), Publisher: American Chemical Society Publications
    Status:
    Published
    DOI:
    10.1021/acsomega.9b02715 – link to the publication

  7. Exploring an Optimised Approach for Converting 6- Thioguanosine Derivatives to Asymmetric Disulphides

    Authors:
    Karol Kurpiejewski, Karolina Piecyk, Paulina Pietrow, Sandra Pancer, Marzena Jankowska-Anyszka
    Academic press:
    European Journal of Organic Chemistry (year: 2024, volume: 27, pages: 46033), Publisher: Wiley-VCH GmbH
    Status:
    Published
    DOI:
    10.1002/ejoc.202301144 – link to the publication

  8. Application of Phosphoramidate ProTide Technology for the Synthesis of 5'-mRNA Cap Analogs Modified on the Exocyclic Amine Group

    Authors:
    Izabela Siekierska, Maciej Lukaszewicz, Remigiusz Worch, Marzena Jankowska-Anyszka, Karolina Piecyk
    Academic press:
    ChemMedChem (year: 2023, volume: 18(4), pages: e202200490), Publisher: Wiley-VCH GmbH, Weinheim
    Status:
    Published
    DOI:
    10.1002/cmdc.202200490 – link to the publication

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