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Information of the project and the call

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Gold and silver nanoparticles as carriers for delivery of 5' end mRNA cap analogues with potential therapeutical application

2018/31/B/ST5/03544

Keywords:

cap analogues gold and silver nanoparticles mRNA translation inhibitors

Descriptors:

  • ST5_23:
  • ST5_10:
  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Warszawski, Wydział Chemii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marzena Jankowska-Anyszka 

Number of co-investigators in the project: 10

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 367 900 PLN

Project start date (Y-m-d): 2019-07-24

Project end date (Y-m-d): 2024-07-23

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (11)
  1. Exploring an Optimised Approach for Converting 6- Thioguanosine Derivatives to Asymmetric Disulphides
    Authors:
    Karol Kurpiejewski, Karolina Piecyk, Paulina Pietrow, Sandra Pancer, Marzena Jankowska-Anyszka
    Academic press:
    European Journal of Organic Chemistry (rok: 2024, tom: 27, strony: 45668), Wydawca: Wiley-VCH GmbH
    Status:
    Published
    DOI:
    10.1002/ejoc.202301144 - link to the publication
  2. Application of Phosphoramidate ProTide Technology for the Synthesis of 5'-mRNA Cap Analogs Modified on the Exocyclic Amine Group
    Authors:
    Izabela Siekierska, Maciej Lukaszewicz, Remigiusz Worch, Marzena Jankowska-Anyszka, Karolina Piecyk
    Academic press:
    ChemMedChem (rok: 2023, tom: 18(4), strony: e202200490), Wydawca: Wiley-VCH GmbH, Weinheim
    Status:
    Published
    DOI:
    10.1002/cmdc.202200490 - link to the publication
  3. Exploring an Optimised Approach for Converting 6- Thioguanosine Derivatives to Asymmetric Disulphides
    Authors:
    Karol Kurpiejewski, Karolina Piecyk, Paulina Pietrow, Sandra Pancer, Marzena Jankowska-Anyszka
    Academic press:
    European Journal of Organic Chemistry (rok: 2024, tom: 27, strony: 45668), Wydawca: Wiley-VCH GmbH
    Status:
    Published
    DOI:
    10.1002/ejoc.202301144 - link to the publication
  4. Decapping Scavenger Enzyme Activity toward N2-Substituted 5′ End mRNA Cap Analogues
    Authors:
    Paulina Pietrow, Aleksandra Ferenc-Mrozek, Karolina Piecyk, Elżbieta Bojarska, Edward Darżynkiewicz, Marzena Jankowska-Anyszka
    Academic press:
    ACS Omega (rok: 2019, tom: 4, strony: 17576-17580), Wydawca: American Chemical Society Publications
    Status:
    Published
    DOI:
    10.1021/acsomega.9b02715 - link to the publication
  5. Application of Phosphoramidate ProTide Technology for the Synthesis of 5'-mRNA Cap Analogs Modified on the Exocyclic Amine Group
    Authors:
    Izabela Siekierska, Maciej Lukaszewicz, Remigiusz Worch, Marzena Jankowska-Anyszka, Karolina Piecyk
    Academic press:
    ChemMedChem (rok: 2023, tom: 18(4), strony: e202200490), Wydawca: Wiley-VCH GmbH, Weinheim
    Status:
    Published
    DOI:
    10.1002/cmdc.202200490 - link to the publication
  6. N2 modified dinucleotide cap analogs as a potent tool for mRNA engineering
    Authors:
    Renata Grzela, Karolina Piecyk, Anna Stankiewicz-Drogon, Paulina Pietrow, Maciej Lukaszewicz, Karol Kurpiejewski, Edward Darzynkiewicz, Marzena Jankowska-Anyszka
    Academic press:
    RNA (rok: 2023, tom: 29(2), strony: 200-216), Wydawca: Cold Spring Harbor Laboratory Press
    Status:
    Published
    DOI:
    10.1261/rna.079460.122 - link to the publication
  7. The potential of N2-modified cap analogues for precise genetic manipulation through mRNA engineering
    Authors:
    Karol Kurpiejewski, Anna Stankiewicz-Drogon, Karolina Piecyk, Eliza Rajkowska, Paulina Skrzypczyk , Jingping Geng, Edward Darzynkiewicz, Renata Grzela, Marzena Jankowska-Anyszka
    Academic press:
    Frontiers in Molecular Biosciences (rok: 2024, tom: 10, strony: 45667), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmolb.2023.1269028 - link to the publication
  8. The Synergistic Effect of N2 and N7 Modifications on the Inhibitory Efficacy of mRNA Cap Analogues
    Authors:
    Karol Kurpiejewski, Karolina Piecyk, Maciej Lukaszewicz, Karol Kamel,, Kazimierz Chmurski; Sebastian Kmiecik Marzena Jankowska-Anyszka
    Academic press:
    Pharmaceuticals (rok: 2024, tom: 17, strony: 632-646), Wydawca: MPDI
    Status:
    Published
    DOI:
    10.3390/ph17050632 - link to the publication
  9. The potential of N2-modified cap analogues for precise genetic manipulation through mRNA engineering
    Authors:
    Karol Kurpiejewski, Anna Stankiewicz-Drogon, Karolina Piecyk, Eliza Rajkowska, Paulina Skrzypczyk , Jingping Geng, Edward Darzynkiewicz, Renata Grzela, Marzena Jankowska-Anyszka
    Academic press:
    Frontiers in Molecular Biosciences (rok: 2024, tom: 10, strony: 45667), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmolb.2023.1269028 - link to the publication
  10. N2 modified cap analogues as translation inhibitors and substrates for preparation of therapeutic mRNA
    Authors:
    Karol Kurpiejewski, Marzena Jankowska-Anyszka, Renata Grzela
    Academic press:
    European Biophysics Journal (rok: 2023, tom: 52, strony: 511-519), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00249-023-01676-7 - link to the publication
  11. Isoxazole-containing 5′ mRNA cap analogues as inhibitors of the translation initiation process
    Authors:
    Karolina Piecyk, Maciej Łukaszewicz, Karol Kamel, Maria Janowska, Paulina Pietrow, Sebastian Kmiecik, Marzena Jankowska-Anyszka
    Academic press:
    Bioorganic Chemistry (rok: 2020, tom: 96, strony: 103583), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2020.103583 - link to the publication

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