Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Restoration of beta-cell function via inhibition of diabetic kinome.

2019/34/E/NZ1/00467

Keywords:

diabetes protein kinase beta cells cell culture inhibitor signaling pathways nanotechnology

Descriptors:

  • NZ1_001:
  • NZ1_004:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Czarna 

Number of co-investigators in the project: 6

Call: SONATA BIS 9 - announced on 2019-06-17

Amount awarded: 2 847 868 PLN

Project start date (Y-m-d): 2020-04-14

Project end date (Y-m-d): 2024-10-13

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  1. Binding mechanism and biological effects of flavone DYRK1A inhibitors for the design of new antidiabetics
    Authors:
    Katarzyna Pustelny, Przemyslaw Grygier, Agata Barzowska, Barbara Pucelik, Alex Matsuda, Krzysztof Mrowiec, Emilia Slugocka, Grzegorz M Popowicz, Grzegorz Dubin, Anna Czarna
    Academic press:
    Scientific reports (rok: 2023, tom: 13, strony: 18114), Wydawca: Nature Publishing Group UK
    Status:
    Published
    DOI:
    10.1038/s41598-023-44810-3 - link to the publication
  2. DYRK1A Kinase Inhibitors Promote β-Cell Survival and Insulin Homeostasis
    Authors:
    Barzowska A, Pucelik B, Pustelny K, Matsuda A, Martyniak A, Stępniewski J, Maksymiuk A, Dawidowski M, Rothweiler U, Dulak J, Dubin G, Czarna A.
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 1,94652777777778), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10092263 - link to the publication
  3. Microscale thermophoresis (MST) and spectral shift (SpS) in drug discovery
    Authors:
    Jakub S. Nowak, Anna Czarna, Przemysław Grudnik, Przemyslaw Grygier, Katarzyna Pustelny, Andreas Langer, Grzegorz Dubin
    Academic press:
    TrAC Trends in Analytical Chemistry (rok: 2024, tom: 176, strony: 117716), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.trac.2024.117716 - link to the publication
  4. Diabetic Kinome Inhibitors—A New Opportunity for β-Cells Restoration.
    Authors:
    Pucelik B, Barzowska A, Dąbrowski JM, Czarna A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 6,97430555555556), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22169083 - link to the publication
  5. Exploring Novel GSK-3β Inhibitors for Anti-Neuroinflammatory and Neuroprotective Effects: Synthesis, Crystallography, Computational Analysis, and Biological Evaluation
    Authors:
    Izabella Góral, Tomasz Wichur, Emilia Sługocka, Przemysław Grygier, Monika Głuch-Lutwin, Barbara Mordyl, Ewelina Honkisz-Orzechowska, Natalia Szałaj, Justyna Godyń, Dawid Panek, Paula Zaręba, Anna Sarka, Paweł Żmudzki, Gniewomir Latacz, Katarzyna Pustelny, Adam Bucki, Anna Czarna, Filipe Menezes, and Anna Więckowska
    Academic press:
    ACS Chemical Neuroscience (rok: 2024, tom: 15 (17), strony: 3181-3201), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acschemneuro.4c00365 - link to the publication
  6. Silmitasertib (CX-4945), a Clinically Used CK2-Kinase Inhibitor with Additional Effects on GSK3β and DYRK1A Kinases: A Structural Perspective
    Authors:
    Przemyslaw Grygier, Katarzyna Pustelny, Jakub Nowak, Przemyslaw Golik, Grzegorz M. Popowicz, Oliver Plettenburg, Grzegorz Dubin, Filipe Menezes, and Anna Czarna
    Academic press:
    Journal of Medicinal Chemistry (rok: 2023, tom: 66 (6), strony: 4009-4024), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.2c01887 - link to the publication
  7. DYRK1A inhibitors leucettines and TGF-β inhibitor additively stimulate insulin production in beta cells, organoids, and isolated mouse islets
    Authors:
    Pucelik B, Barzowska A, Czarna A
    Academic press:
    PLOS ONE (rok: 2023, tom: 18(5), strony: e0285208), Wydawca: PLOS ONE
    Status:
    Published
    DOI:
    10.1371/journal.pone.0285208 - link to the publication
  8. Structural perspective on the design of selective DYRK1B inhibitors
    Authors:
    Przemyslaw Grygier, Katarzyna Pustelny, Grzegorz Dubin, Anna Czarna
    Academic press:
    Biorxiv (rok: 2022, tom: 2022.12.23.521429, strony: 2022.12.23.521429), Wydawca: Biorxiv
    Status:
    Published
    DOI:
    10.1101/2022.12.23.521429 - link to the publication

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