Dual action mode inhibitors of urease and their anti-virulent activity against Helicobacter pylori and Cryptococcus neoformans
2018/31/B/NZ6/02017
Keywords
Descriptors
- NZ6_4: Bakteriologia
- ST5_16: Chemia biologiczna
- NZ1_2: Biochemia
Panel
NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology
Host institution
Politechnika Wrocławska
Voivodeship: dolnośląskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 8
Call
OPUS 16 – announced on 2018-09-14
- Amount awarded
- 1 629 000 PLN
- Project start date
- 2019-09-02
- Project end date
- 2023-09-01
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Autoklaw.
- Chłodziarko-zamrażarka.
- Dysk twardy.
- Homogenizator ultradzwiękowy. Cost: 22 000 PLN
- Inkubator z wytrząsaniem. Cost: 56 000 PLN
- Mikroskop stereoskopowy. Cost: 28 000 PLN
- System oczyszczania białek ÄKTA pure z wyposażeniem i kolumnami chromatograficznymi. Cost: 270 000 PLN
- Wyparka rotacyjna z pompą. Cost: 21 000 PLN
- Zestaw dwóch inkubatorów z wytrząsaniem.
Information in the final report
Publication in academic press/journals (6)
-
Covalent Inhibition of Bacterial Urease by Bifunctional Catechol-Based Phosphonates and Phosphinates
- Authors:
- Aikaterini Pagoni, Agnieszka Grabowiecka, Wojciech Tabor, Artur Mucha, Stamatia Vassiliou, Łukasz Berlicki
- Academic press:
- Journal of Medicinal Chemistry (year: 2021, volume: 64, pages: 404–416), Publisher: American Chemical Society
- Status:
- Published
- DOI:
- 10.1021/acs.jmedchem.0c01143 – link to the publication
-
Antibacterial Activity of Ebselen
- Authors:
- Marta Maślanka, Artur Mucha
- Academic press:
- International Journal of Molecular Sciences (year: 2023, volume: 24, pages: 1610), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms24021610 – link to the publication
-
Rational development of bacterial ureases inhibitors
- Authors:
- Saurabh Loharch, Łukasz Berlicki
- Academic press:
- The Chemical Record (year: 2022, volume: 22, pages: e202200026), Publisher: Wiley
- Status:
- Published
- DOI:
- 10.1002/tcr.202200026 – link to the publication
-
Optimized Ebselen-Based Inhibitors of Bacterial Ureases with Nontypical Mode of Action
- Authors:
- Katarzyna Macegoniuk, Wojciech Tabor, Luca Mazzei, Michele Cianci, Mirosław Giurg, Kamila Olech, Małgorzata Burda-Grabowska, Rafał Kaleta, Agnieszka Grabowiecka, Artur Mucha, Stefano Ciurli, Łukasz Berlicki
- Academic press:
- Journal of Medicinal Chemistry (year: 2023, volume: 66, pages: 2054−2063), Publisher: American Chemical Society
- Status:
- Published
- DOI:
- 10.1021/acs.jmedchem.2c01799 – link to the publication
-
Inhibitory activity of catecholic phosphonic and phosphinic acids against Helicobacter pylori ureolysis
- Authors:
- Marta Maślanka, Wojciech Tabor, Paweł Krzyżek, Agnieszka Grabowiecka, Łukasz Berlicki, Artur Mucha
- Academic press:
- European Journal of Medicinal Chemistry (year: 2023, volume: 257, pages: 115528), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.ejmech.2023.115528 – link to the publication
-
Phosphinic acid-based enzyme inhibitors
- Authors:
- Stamatia Vassiliou, Aikaterini Pagoni, Ewelina Węglarz-Tomczak, Michał Talma, Wojciech Tabor, Agnieszka Grabowiecka, Łukasz Berlicki, Artur Mucha
- Academic press:
- Phosphorus, Sulfur, and Silicon and the Related Elements (year: 2022, volume: 197, pages: 451–456), Publisher: Taylor & Francis
- Status:
- Published
- DOI:
- 10.1080/10426507.2021.2011882 – link to the publication