DNA polymerase θ as a novel therapeutic target in personalized anticancer therap

DNA polymerase θ as a novel therapeutic target in personalized anticancer therapy

2020/37/B/NZ7/00422

Keywords

Descriptors

NZ7_014: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Tomasz Adam Śliwiński

Number of co-investigators in the project: 9

Call

OPUS 19 – announced on 2020-03-16

Amount awarded: 1 614 000 PLN
Project start date: 2021-02-05
Project end date: 2025-02-04
Project duration: 48 months (the same as in the proposal)
Project status: Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (3)

Polθ Inhibitor (ART558) Demonstrates a Synthetic Lethal Effect with PARP and RAD52 Inhibitors in Glioblastoma Cells

Authors:
Gabriela Barszczewska-Pietraszek , Piotr Czarny, Małgorzata Drzewiecka, Maciej Błaszczyk, Maciej Radek, Ewelina Synowiec, Paulina Wigner-Jeziorska, Przemysław Sitarek, Janusz Szemraj, Tomasz Skorski, Tomasz Śliwiński

Academic press:
Int. J. Mol. Sci. (year: 2024, volume: 17, pages: 9134), Publisher: MDPI

Status:
Published

DOI:
10.3390/ijms25179134. – link to the publication
Pol Inhibition: An Anticancer Therapy for HR-Deficient Tumours

Authors:
Gabriela Barszczewska-Pietraszek, Małgorzata Drzewiecka, Piotr Czarny, Tomasz Skorski, Tomasz Śliwiński

Academic press:
Int. J. Mol. Sci (year: 2023, volume: 24, pages: 319-334), Publisher: MDPI

Status:
Published

DOI:
10.3390/ijms24010319 – link to the publication
Synthetic Lethality Targeting Pol

Authors:
Małgorzata Drzewiecka, Gabriela Barszczewska-Pietraszek, Piotr Czarny, Tomasz Skorski, Tomasz Śliwiński

Status:
Accepted for publication

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