Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Structure optimization of the PD-1/PD-L1 inhibitors based on the terphenyl scaffold

2020/37/N/ST4/02691

Keywords:

PD-L1 cancer terphenyl organic synthesis optimization SAR analysis

Descriptors:

  • ST4_009:
  • ST4_008:
  • ST4_003:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Jagielloński, Wydział Chemii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Damian Muszak 

Number of co-investigators in the project: 2

Call: PRELUDIUM 19 - announced on 2020-03-16

Amount awarded: 139 940 PLN

Project start date (Y-m-d): 2021-02-01

Project end date (Y-m-d): 2023-01-31

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Exploring the Surface of the Ectodomain of the PD-L1 Immune Checkpoint with Small-Molecule Fragments
    Authors:
    Radoslaw Kitel, Ismael Rodríguez, Xabier del Corte, Jack Atmaj, Magdalena Żarnik, Ewa Surmiak, Damian Muszak, Katarzyna Magiera-Mularz, Grzegorz M. Popowicz, Tad A. Holak, and Bogdan Musielak
    Academic press:
    ACS Chemical Biology (rok: 2022, tom: 17, strony: 2655–2663), Wydawca: ACS Publicationa
    Status:
    Published
    DOI:
    10.1021/acschembio.2c00583 - link to the publication
  2. Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein–Protein Interaction
    Authors:
    Damian Muszak, Ewa Surmiak, Jacek Plewka, Katarzyna Magiera-Mularz, Justyna Kocik-Krol, Bogdan Musielak, Dominik Sala, Radoslaw Kitel, Malgorzata Stec, Kazimierz Weglarczyk, Maciej Siedlar, Alexander Dömling, Lukasz Skalniak, and Tad A. Holak
    Academic press:
    Journal of Medicinal Chemistry (rok: 2021, tom: 64, strony: 11614–11636), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.1c00957 - link to the publication
  3. Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein–Protein Interaction
    Authors:
    Damian Muszak, Ewa Surmiak, Jacek Plewka, Katarzyna Magiera-Mularz, Justyna Kocik-Krol, Bogdan Musielak, Dominik Sala, Radoslaw Kitel, Malgorzata Stec, Kazimierz Weglarczyk, Maciej Siedlar, Alexander Dömling, Lukasz Skalniak, and Tad A. Holak
    Academic press:
    Journal of Medicinal Chemistry (rok: 2021, tom: 64, strony: 11614–11636), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.1c00957 - link to the publication

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