Projects funded by the NCN
Novel, rationally designed modulators of glycosomal import of enzymes in Trypanosoma parasites
2018/31/B/NZ7/02089
Keywords:
medicinal chemistry protein-protein interaction inhibitors PPI glycosome
Descriptors:
- NZ7_14:
- NZ1_10:
- NZ6_6:
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 4
Call: OPUS 16 - announced on 2018-09-14
Amount awarded: 1 719 100 PLN
Project start date (Y-m-d): 2019-07-08
Project end date (Y-m-d): 2024-07-07
Project duration:: 60 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- Computer-Aided Design and Synthesis of a New Class of PEX14 Inhibitors: Substituted 2,3,4,5- tetrahydrobenzo[f][1,4]oxazepines as Potential New Trypanocidal AgentsAuthors:Roberto Fino, Dominik Lenhart, Vishal C. Kalel, Charlotte A. Softley, Valeria Napolitano, Ryan Byrne, Wolfgang Schliebs, Maciej Dawidowski, Ralf Erdmann, Michael Sattler, Gisbert Schneider, Oliver Plettenburg, Grzegorz Popowicz*Academic press:Journal of Chemical Information and Modeling (rok: 2021, tom: 61, strony: 5256−5268), Wydawca: American Chemical SocietyStatus:PublishedDOI:10.1021/acs.jcim.1c00472 - link to the publication