Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Association of TXNDC5 and calreticulin with decreased ER stress, allowing resistant multiple myeloma cells to by-pass proteasome inhibition.

2018/29/N/NZ5/00651

Keywords:

multiple myeloma proteasome inhibitors resistance ER stress TXNDC5 calreticulin

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Tadeusz Kubicki 

Number of co-investigators in the project: 3

Call: PRELUDIUM 15 - announced on 2018-03-15

Amount awarded: 210 000 PLN

Project start date (Y-m-d): 2019-02-18

Project end date (Y-m-d): 2022-02-17

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. Bortezomib- and carfilzomib-resistant myeloma cells show increased activity of all three arms of the unfolded protein response
    Authors:
    Tadeusz Kubicki, Kinga Bednarek, Magdalena Kostrzewska-Poczekaj, Magdalena Luczak, Krzysztof Lewandowski, Lidia Gil, Malgorzata Jarmuz-Szymczak, Dominik Dytfeld
    Academic press:
    American Journal of Cancer Research (rok: 2022, tom: 12(7), strony: 3280-3293), Wydawca: E-CENTURY PUBLISHING CORP
    Status:
    Published
    DOI:
    2156-6976/ajcr0143092 - link to the publication
  2. Endoplasmic reticulum stress and proteasome inhibitors in multiple myeloma – a room for improvement.
    Authors:
    Tadeusz Kubicki, Lidia Gil, Dominik Dytfeld
    Academic press:
    Polish Archives of Internal Medicine (rok: 2021, tom: 131(4), strony: 361-368), Wydawca: Medycyna Praktyczna
    Status:
    Published
    DOI:
    10.20452/pamw.15896 - link to the publication

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