Projects funded by the NCN
Multitarget approach to break the vicious circle of tau pathology and neuroinflammation in Alzheimer's disease: development of dual inhibitors of GSK-3β and IKK-β kinases
2019/34/E/NZ7/00090
Keywords:
medicinal chemistry multifunctional ligands Alzheimer's disease tau protein neuroinflammation
Descriptors:
- NZ7_014:
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Uniwersytet Jagielloński, Collegium Medicum
woj. małopolskie
Principal investigator (from the host institution):
dr hab. Anna Karolina Więckowska
Number of co-investigators in the project: 10
Call: SONATA BIS 9 - announced on 2019-06-17
Amount awarded: 2 414 780 PLN
Project start date (Y-m-d): 2020-04-10
Project end date (Y-m-d): 2026-04-09
Project duration:: 72 months (the same as in the proposal)
Project status: Pending project
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (2)
- Exploring Novel GSK-3β Inhibitors for Anti-Neuroinflammatory and Neuroprotective Effects: Synthesis, Crystallography, Computational Analysis, and Biological EvaluationAuthors:Góral, I.; Wichur, T.; Sługocka, E.; Grygier, P.; Głuch-Lutwin, M.; Mordyl, B.; Honkisz-Orzechowska, E.; Szałaj, N.; Godyń, J.; Panek, D.; Zaręba, P.; Sarka, A.; Żmudzki, P.; Latacz, G.; Pustelny, K.; Bucki, A.; Czarna, A.; Menezes, F.; Więckowska, A.Academic press:ACS Chemical Neuroscience (rok: 2024, tom: 15, strony: 3181-3201), Wydawca: ACS PublicationsStatus:PublishedDOI:10.1021/acschemneuro.4c00365 - link to the publication
- Connecting GSK-3β Inhibitory Activity with IKK-β or ROCK-1 Inhibition to Target Tau Aggregation and Neuroinflammation in Alzheimer's Disease—Discovery, In Vitro and In Cellulo Activity of Thiazole-Based InhibitorsAuthors:Góral, I.; Wichur, T.; Sługocka, E.; Godyń, J.; Szałaj, N.; Zaręba, P.; Głuch-Lutwin, M.; Mordyl, B.; Panek, D.; Więckowska, A.Academic press:Molecules (rok: 2024, tom: 29, strony: 2616), Wydawca: MDPIStatus:PublishedDOI:10.3390/molecules29112616 - link to the publication