Multitarget approach to break the vicious circle of tau pathology and neuroinfla

Multitarget approach to break the vicious circle of tau pathology and neuroinflammation in Alzheimer's disease: development of dual inhibitors of GSK-3β and IKK-β kinases

2019/34/E/NZ7/00090

Keywords

Descriptors

NZ7_014: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Jagielloński, Collegium Medicum

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Anna Karolina Więckowska

Number of co-investigators in the project: 10

Call

SONATA BIS 9 – announced on 2019-06-17

Amount awarded: 2 414 780 PLN
Project start date: 2020-04-10
Project end date: 2026-12-09
Project duration: 80 months (the same as in the proposal)
Project status: Pending project

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (2)

Connecting GSK-3β Inhibitory Activity with IKK-β or ROCK-1 Inhibition to Target Tau Aggregation and Neuroinflammation in Alzheimer's Disease—Discovery, In Vitro and In Cellulo Activity of Thiazole-Based Inhibitors

Authors:
Góral, I.; Wichur, T.; Sługocka, E.; Godyń, J.; Szałaj, N.; Zaręba, P.; Głuch-Lutwin, M.; Mordyl, B.; Panek, D.; Więckowska, A.

Academic press:
Molecules (year: 2024, volume: 29, pages: 2616), Publisher: MDPI

Status:
Published

DOI:
10.3390/molecules29112616 – link to the publication
Exploring Novel GSK-3β Inhibitors for Anti-Neuroinflammatory and Neuroprotective Effects: Synthesis, Crystallography, Computational Analysis, and Biological Evaluation

Authors:
Góral, I.; Wichur, T.; Sługocka, E.; Grygier, P.; Głuch-Lutwin, M.; Mordyl, B.; Honkisz-Orzechowska, E.; Szałaj, N.; Godyń, J.; Panek, D.; Zaręba, P.; Sarka, A.; Żmudzki, P.; Latacz, G.; Pustelny, K.; Bucki, A.; Czarna, A.; Menezes, F.; Więckowska, A.

Academic press:
ACS Chemical Neuroscience (year: 2024, volume: 15, pages: 3181-3201), Publisher: ACS Publications

Status:
Published

DOI:
10.1021/acschemneuro.4c00365 – link to the publication

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