Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Cellular mechanisms and effects in vivo of selective lactate dehydrogenase A inhibitors in experimental models of mesothelioma

2018/31/B/NZ7/02909

Keywords:

metabolism mesothelioma endothelium lactate dehydrogenase anticancer therapy

Descriptors:

  • NZ1_2:
  • NZ7_14:
  • NZ4_11:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Lekarski

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Godefridus J Peters 

Number of co-investigators in the project: 7

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 288 800 PLN

Project start date (Y-m-d): 2019-08-21

Project end date (Y-m-d): 2024-08-20

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (14)
  1. Effects of nucleoside analogues, lipophilic prodrugs and elaidic acids on core signaling pathways in cancer cells
    Authors:
    Marika A. Frańczak, Claudine van der Sande, Elisa Giovannetti, Godefridus J. Peters
    Academic press:
    Nucleosides, Nucleotides & Nucleic Acids (rok: 2024, tom: Brak, strony: 46033), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2024.2339952 - link to the publication
  2. Metabolic Effects of New Glucose Transporter (GLUT-1) and Lactate Dehydrogenase-A (LDH-A) Inhibitors against Chemoresistant Malignant Mesothelioma
    Authors:
    Marika A. Franczak, Oliwia Krol, Gabriela Harasim, Agata Jedrzejewska, Nadia Zaffaroni, Carlotta Granchi, Filippo Minutolo, Amir Avan, Elisa Giovannetti, Ryszard T. Smolenski, Godefridus J. Peters
    Academic press:
    Int. J. Mol.Sci. (rok: 2023, tom: 24(9), strony: 7771), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24097771 - link to the publication
  3. Evaluation of the combination of gemcitabine, carboplatin, and lactate dehydrogenase A inhibitor on malignant mesothelioma
    Authors:
    Marika A Frańczak, Federica Borea, Ryszard T. Smoleński, Carlotta Granchi, Filippo Minutolo, Elisa Giovannetti & Godefridus J. Peters
    Academic press:
    Nucleosides Nucleotides Nucleic Acids (rok: 2024, tom: Brak, strony: 46030), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2024.2356201 - link to the publication
  4. The Influence of Mitochondrial Energy and 1C Metabolism on the Efficacy of Anticancer Drugs: Exploring Potential Mechanisms of Resistance
    Authors:
    Marika Franczak, Isabel Toenshoff, Gerrit Jansen, Ryszard T. Smolenski, Elisa Giovannetti and Godefridus J. Peters
    Academic press:
    Current Medicinal Chemistry (rok: 2022, tom: 30, strony: 1209-1231), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/0929867329666220401110418 - link to the publication
  5. Effects of lactate dehydrogenase A and GLUT1 inhibition on human endothelial cell migration in relation to their intracellular nucleotide pool
    Authors:
    Gabriela Harasim, Marika A. Frańczak, Filippo Minutolo, Carlotta Granchi, Elisa Giovannetti, Ewa M. Słomińska, Ryszard T. Smoleński, Godefridus J. Peters
    Academic press:
    Nucleosides Nucleotides Nucleic Acids (rok: 2024, tom: Brak, strony: 46031), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2024.2379321 - link to the publication
  6. Lactate dehydrogenase A inhibition by small molecular entities: steps in the right direction
    Authors:
    Btissame El Hassouni, Marika Franczak, Mjriam Capula, Christian M. Vonk, Valentina M. Gomez, Ryszard T. Smolenski, Carlotta Granchi, Godefridus J. Peters, Filippo Minutolo, Elisa Giovannetti
    Academic press:
    Oncoscience (rok: 2020, tom: 7, strony: 76-80), Wydawca: Impact Journals (Ostatni IF = 3,16, brak informacji o IF za ostatni rok)
    Status:
    Published
    DOI:
    10.18632/oncoscience.519 - link to the publication
  7. Lactate Dehydrogenase and its clinical significance in pancreatic and thoracic cancers
    Authors:
    Annalisa Comandatore, Marika Franczak, Ryszard T. Smolenski, Luca Morelli, Godefridus J. Peters, Elisa Giovannetti
    Academic press:
    Seminars in Cancer Biology (rok: 2022, tom: 86, strony: 93-100), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.semcancer.2022.09.001 - link to the publication
  8. Splicing deregulation, microRNA and notch aberrations: fighting the three-headed dog to overcome drug resistance in malignant mesothelioma
    Authors:
    Dario P. Anobile, Giulia Montenovo, Camilla Pecoraro, Marika Franczak, Widad Ait Iddouch, Godefridus J Peters, Chiara Riganti & Elisa Giovannetti
    Academic press:
    Expert Review of Clinical Pharmacology (rok: 2022, tom: 15, strony: 305-322), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/17512433.2022.2074835 - link to the publication
  9. Target Therapy in Malignant Pleural Mesothelioma: Hope or Mirage?
    Authors:
    Federica Borea, Marika A. Franczak, Maria Garcia, Matteo Perrino, Nadia Cordua, Ryszard T. Smolenski, Godefridus J. Peters, Rafal Dziadziuszko, Armando Santoro, Paolo A. Zucali, Elisa Giovannetti
    Academic press:
    Int. J. Mol. Sci. (rok: 2023, tom: 24, strony: 9165), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24119165 - link to the publication
  10. A bug in the resistance to EGFR inhibitors: is there a role for Mycoplasma and cytidine deaminase in reducing the activity of osimertinib in lung cancer patients?
    Authors:
    Alessandro Leonetti1,2,3 · Daniela Carbone3,4 · Alessandro Gregori3 · Marcello Tiseo1,2 · Godefridus J. Peters3,5 · Dongmei Deng6 · Elisa Giovannetti3,7
    Academic press:
    Journal of Cancer Research and Clinical Oncology (rok: 2021, tom: 147, strony: 3135-3137), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00432-021-03647-x - link to the publication
  11. The effect of lactate dehydrogenase-A inhibition on intracellular nucleotides and mitochondrial respiration in pancreatic cancer cells
    Authors:
    Marika Franczak, Barbara Kutryb-Zajac, Btissame El Hassouni, Elisa Giovannetti, Carlotta Granchi, Filippo Minutolo, Ryszard T. Smolenski & Godefridus J. Peters
    Academic press:
    Nucleosides, Nucleotides & Nucleic Acids (rok: 2022, tom: 41, strony: 1375-138), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2022.2031215 - link to the publication
  12. Are we still on the right path(way)?: the altered expression of the pentose phosphate pathway in solid tumors and the potential of its inhibition in combination therapy
    Authors:
    Caroline J.W. Meskers, Marika Franczak, Ryszard T. Smolenski, Elisa Giovannetti & Godefridus J. Peters
    Academic press:
    Expert Opinion on Drug Metabolism & Toxicology (rok: 2022, tom: 18, strony: 61-83), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/17425255.2022.2049234 - link to the publication
  13. Impact of hypoxia on chemoresistance of mesotheliomamediated by the proton-coupled folate transporter, andpreclinical activity of new anti-LDH-A compounds
    Authors:
    Giovanna Li Petri, Btissame El Hassouni, Rocco Sciarrillo, Niccola Funel, Giulia Mantini, Eveline A Zeeuw van der Laan, Stella Cascioferro, Amir Avan, Paolo Andrea Zucali, Nadia Zaffaroni, Tonny Lagerweij, Barbara Parrino, Kees Smid, Marcello Deraco, Carlotta Granchi, Alicja Braczko, Ryszard T Smolenski, Larry H Matherly, Gerrit Jansen, Yehuda G Assaraf, Patrizia Diana, Jacqueline Cloos, Godefridus J Peters, Filippo Minutolo, Elisa Giovannetti
    Academic press:
    British Journal of Cancer (rok: 2020, tom: 123, strony: 644-656), Wydawca: Nature Publishing Group. Data pierwszego zgłoszenia pracy to 2019-10-11. Poniżej podano datę złożenia do redakcji korety zawierającej dane z projektu.
    Status:
    Published
    DOI:
    10.1038/s41416-020-0912-9 - link to the publication
  14. Role of exosomes in transferring chemoresistance through modulation of cancer glycolytic cell metabolism
    Authors:
    Mahrou Vahabi, Annalisa Comandatore, Marika A. Franczak, Ryszard T. Smolenski, Godefridus J. Peters, Luca Morelli, Elisa Giovannetti
    Academic press:
    Cytokine Growth Factor Rev (rok: 2023, tom: 73, strony: 163-172), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cytogfr.2023.07.004 - link to the publication

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