Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Development of new and more efficient treatment against mesothelioma utilizing oncolytic adenovirus armed with ICOS ligand combined with check point inhibitor anti PD-1

2019/32/C/NZ7/00156

Keywords:

oncolytic adenovirus immuno-oncology mesothelioma murine cancer models

Descriptors:

  • NZ6_5: Virology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Narodowy Instytut Zdrowia Publicznego - Państwowy Zakład Higieny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Łukasz Kuryk 

Number of co-investigators in the project: 1

Call: SONATINA 3 - announced on 2018-12-14

Amount awarded: 763 168 PLN

Project start date (Y-m-d): 2019-08-26

Project end date (Y-m-d): 2022-08-25

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (10)
  1. Polymer Coated Oncolytic Adenovirus to Selectively Target Hepatocellular Carcinoma Cells
    Authors:
    Mariangela Garofalo, Federica Bellato, Salvatore Magliocca, Alessio Malfanti, Lukasz Kuryk, Beate Rinner, Samuele Negro, Stefano Salmaso, Paolo Caliceti and Francesca Mastrotto
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13, strony: (949) 1-20), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13070949 - link to the publication
  2. Combination of a novel oncolytic adenovirus Ad5-D24-ICOSL-CD40L with anti PD-1 exhibits enhanced anticancer efficacy and promotes intratumoral T cell infiltration in humanized H226 mesothelioma mouse model
    Authors:
    Mariangela Garofalo, Magdalena Wieczorek, Ines Anders, Monika Staniszewska, Michal Lazniewski, Marta Prygiel, Aleksandra Zasada, Teresa Szczepińska, Dariusz Plewczynski, Stefano Salmaso, Paolo Caliceti, Vincenzo Cerullo, Ramon Alemany, Beate Rinner, Katarzyna Pancer and Lukasz Kuryk
    Academic press:
    OncoImmunology (rok: 2022, ), Wydawca: Taylor and Francis online
    Status:
    Submitted
    DOI:
    brak - link to the publication
  3. Chimeric oncolytic Ad5/3 virus replicates and lyses ovarian cancer cells through desmoglein‐2 cell entry receptor
    Authors:
    Lukasz Kuryk, Anne‐Sophie W. Møller
    Academic press:
    Journal of Medical Virology (rok: 2020, tom: 92, strony: 1309-1315), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/jmv.25677 - link to the publication
  4. From conventional therapies to immunotherapy: Melanoma treatment in review
    Authors:
    Lukasz Kuryk, Laura Bertinato, Monika Staniszewska, Katarzyna Pancer, Magdalena Wieczorek, Stefano Salmaso, Paolo Caliceti and Mariangela Garofalo
    Academic press:
    Cancers (rok: 2020, tom: 12, strony: 3057), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12103057 - link to the publication
  5. The Multifaceted Roles of Mast Cells in Immune Homeostasis, Infections and Cancers
    Authors:
    Anna Sobiepanek, Łukasz Kuryk, Mariangela Garofalo, Sandeep Kumar, Joanna Baran, Paulina Musolf, Frank Siebenhaar, Joachim Wilhelm Fluhr, Tomasz Kobiela, Roberto Plasenzotti, Karl Kuchlerand Monika Staniszewska
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 45322), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23042249 - link to the publication
  6. Combination Therapy of Novel Oncolytic Adenovirus with Anti-PD1 Resulted in Enhanced Anti-Cancer Effect in Syngeneic Immunocompetent Melanoma Mouse Model
    Authors:
    Mariangela Garofalo, Laura Bertinato, Monika Staniszewska, Magdalena Wieczorek , Stefano Salmaso, Silke Schrom, Beate Rinner, Katarzyna Wanda Pancer and Lukasz Kuryk
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13, strony: 537 (1-22)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13040547 - link to the publication
  7. Novel Insights Into Mesothelioma Therapy: Emerging Avenues and Future Prospects
    Authors:
    Lukasz Kuryk, Giulia Rodella, Monika Staniszewska, Katarzyna Wanda Pancer, Magdalena Wieczorek, Stefano Salmaso, Paolo Caliceti and Mariangela Garofalo
    Academic press:
    Frontiers in Oncology (rok: 2022, tom: 12, strony: brak), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fonc.2022.916839 - link to the publication
  8. Cancer-derived EVs show tropism for tissues at early stage of neoplastic transformation
    Authors:
    Mariangela Garofalo, Alessandro Villa, Electra Brunialti, Daniela Crescenti, Giulia Dell'Omo, Lukasz Kuryk, Andrea Vingiani, Vincenzo Mazzaferro, Paolo Ciana
    Academic press:
    Nanotheranostics (rok: 2020, tom: 5, strony: 45298), Wydawca: Ivyspring
    Status:
    Published
    DOI:
    10.7150/ntno.47226 - link to the publication
  9. From Immunosuppression to Immunomodulation – Turning Cold Tumours into Hot
    Authors:
    Mariangela Garofalo, Katarzyna Wanda Pancer, Magdalena Wieczorek, Monika Staniszewska, Stefano Salmaso, Paolo Caliceti, and Lukasz Kuryk
    Academic press:
    Journal of Cancer (rok: 2022, tom: 13, strony: 2844-2892), Wydawca: IvySpring
    Status:
    Published
    DOI:
    10.7150/jca.71992 - link to the publication
  10. Prospects of replication-deficient adenovirus based vaccine development against SARS-CoV-2
    Authors:
    Mariangela Garofalo, Monika Staniszewska, Stefano Salmaso, Paolo Caliceti, Katarzyna Wanda Pancer, Magdalena Wieczorek and Lukasz Kuryk
    Academic press:
    Vaccines (rok: 2020, tom: 8, strony: 293), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/vaccines8020293 - link to the publication

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