Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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A new approach of vision restoration based on modified Rabies virus tracing technique

2019/34/E/NZ5/00434

Keywords:

Rabies virus neuronal tracing inhibitory interneurons bipolar cells retina vision restoration gene therapy viral therapy

Descriptors:

  • NZ5_007:
  • NZ5_008:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Chemii Fizycznej Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Andrzej Tomasz Foik 

Number of co-investigators in the project: 4

Call: SONATA BIS 9 - announced on 2019-06-17

Amount awarded: 3 457 800 PLN

Project start date (Y-m-d): 2020-05-26

Project end date (Y-m-d): 2026-05-25

Project duration:: 72 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (10)
  1. Visual system hyperexcitability and compromised V1 receptive field properties in early-stage Retinitis Pigmentosa in mice
    Authors:
    Leinonen H, Lyon DC, Palczewski K, Foik AT
    Academic press:
    eNeuro (rok: 2022, tom: Vol 9 Issue 3, strony: 45673), Wydawca: Society for Neuroscience
    Status:
    Published
    DOI:
    10.1523/ENEURO.0107-22.2022 - link to the publication
  2. Distinct mouse models of Stargardt disease display differences in pharmacological targeting of ceramides and inflammatory responses
    Authors:
    Engfer, Z. J., Lewandowski, D., Dong, Z., Palczewska, G., Zhang, J., Kordecka, K., Płaczkiewicz, J., Panas, D., Foik, A. T., Tabaka, M., & Palczewski, K.
    Academic press:
    Proceedings of the National Academy of Sciences (rok: 2023, tom: 120 (50), strony: e2314698120), Wydawca: PNAS
    Status:
    Published
    DOI:
    10.1073/PNAS.2314698120 - link to the publication
  3. Traumatic brain injury to primary visual cortex produces long-lasting circuit dysfunction
    Authors:
    Frankowski, J.C., Foik, A.T., Tierno, A. et al
    Academic press:
    Current Biology (rok: 2021, tom: 4, strony: 1297), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s42003-021-02808-5 - link to the publication
  4. Traumatic brain injury to primary visual cortex produces long-lasting circuit dysfunction
    Authors:
    Frankowski, J.C., Foik, A.T., Tierno, A. et al
    Academic press:
    Communications Biology (rok: 2021, tom: 4, strony: 1297), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s42003-021-02808-5 - link to the publication
  5. A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models
    Authors:
    Leinonen H, Zhang J, Occelli LM, Seemab U, Choi EH, L P Marinho LF, Querubin J, Kolesnikov AV, Galinska A, Kordecka K, Hoang T, Lewandowski D, Lee TT, Einstein EE, Einstein DE, Dong Z, Kiser PD, Blackshaw S, Kefalov VJ, Tabaka M, Foik A, Petersen-Jones SM, Palczewski KA
    Academic press:
    Nature Communications (rok: 2024, tom: 15(1), strony: 5943), Wydawca: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41467-024-50033-5. - link to the publication
  6. In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration
    Authors:
    Elliot H. Choi, Susie Suh, Andrzej T. Foik, Henri Leinonen, Gregory A. Newby, Xin D. Gao, Samagya Banskota, Thanh Hoang , Samuel W. Du, Zhiqian Dong, Aditya Raguram, Sajeev Kohli, Seth Blackshaw, David C. Lyon, David R. Liu, Krzysztof Palczewski
    Academic press:
    Nature Communications (rok: 2022, tom: 13, strony: Article number: 1830 (2022)), Wydawca: Springer Nature Limited
    Status:
    Published
    DOI:
    10.1038/s41467-022-29490-3 - link to the publication
  7. Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations
    Authors:
    Hołubowicz R, Du SW, Felgner J, Smidak R, Choi EH, Palczewska G, Menezes CR, Dong Z, Gao F, Medani O, Yan AL, Hołubowicz MW, Chen PZ, Bassetto M, Risaliti E, Salom D, Workman JN, Kiser PD, Foik AT, Lyon DC, Newby GA, Liu DR, Felgner PL, Palczewski K.
    Academic press:
    Nature Biomedical Engineering (rok: 2024, tom: 9(1), strony: 57-78), Wydawca: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41551-024-01296-2 - link to the publication
  8. A. In vivo volumetric analysis of retinal vascular hemodynamics in mice with spatio-temporal optical coherence tomography
    Authors:
    Węgrzyn P, Kulesza W, Wielgo M, Tomczewski S, Galińska A, Bałamut B, Kordecka K, Cetinkaya O, Foik A, Zawadzki RJ, Borycki D, Wojtkowski M, Curatolo A
    Academic press:
    Neurophotonics (rok: 2024, tom: 11(4), strony: 0450031-4500322), Wydawca: SPIE
    Status:
    Published
    DOI:
    10.1117/1.NPh.11.4.045003 - link to the publication
  9. In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration
    Authors:
    Elliot H. Choi, Susie Suh, Andrzej T. Foik, Henri Leinonen, Gregory A. Newby, Xin D. Gao, Samagya Banskota, Thanh Hoang , Samuel W. Du, Zhiqian Dong, Aditya Raguram, Sajeev Kohli, Seth Blackshaw, David C. Lyon, David R. Liu, Krzysztof Palczewski
    Academic press:
    Nature Communications (rok: 2022, tom: 13, strony: Article number: 1830 (2022)), Wydawca: Springer Nature Limited
    Status:
    Published
    DOI:
    10.1038/s41467-022-29490-3 - link to the publication
  10. Distinct mouse models of Stargardt disease display differences in pharmacological targeting of ceramides and inflammatory responses
    Authors:
    Engfer, Z. J., Lewandowski, D., Dong, Z., Palczewska, G., Zhang, J., Kordecka, K., Płaczkiewicz, J., Panas, D., Foik, A. T., Tabaka, M., & Palczewski, K.
    Academic press:
    Proceedings of the National Academy of Sciences (rok: 2023, tom: 120 (50), strony: e2314698120), Wydawca: PNAS
    Status:
    Published
    DOI:
    10.1073/PNAS.2314698120 - link to the publication

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