Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Radiolabelled peptidomimetic inhibitors of the VEGF/NRP-1 complex for imaging of pathological angiogenesis associated with early stage of malignant tumours formation

2019/33/B/NZ7/02818

Keywords:

radiopharmaceuticals tumors peptidomimetics xenografts

Descriptors:

  • NZ7_014:
  • ST4_009:
  • ST4_018:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Warszawski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Aleksandra Misicka-Kęsik 

Number of co-investigators in the project: 8

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 1 777 880 PLN

Project start date (Y-m-d): 2020-02-24

Project end date (Y-m-d): 2025-02-23

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (1)
  1. Synthesis, Physicochemical and Biological Study of Gallium-68-and Lutetium-177-Labeled VEGF-A165 /NRP-1 Complex Inhibitors Based on Peptide A7R and Branched Peptidomimetic
    Authors:
    Katarzyna Masłowska, Ewa Witkowska, Dagmara Tymecka, Paweł Krzysztof Halik, Aleksandra Misicka, Ewa Gniazdowska
    Academic press:
    Pharmaceutics (rok: 2022, tom: 14, strony: 100), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics14010100 - link to the publication
  2. Does cysteine rule (Cysr) complete the cendr principle? increase in affinity of peptide ligands for NRP-1 through the presence of N-terminal cysteine
    Authors:
    Anna K. Puszko, Piotr Sosnowski, Françoise Raynaud, Olivier Hermine, Gérard Hopfgartner, Yves Lepelletier, Aleksandra Misicka
    Academic press:
    Biomolecules (rok: 2020, tom: 10, strony: 448), Wydawca: MDPI AG
    Status:
    Published
    DOI:
    10.3390/biom10030448 - link to the publication
  3. The Role of VEGF Receptors as Molecular Target in NuclearMedicine for Cancer Diagnosis and Combination Therapy
    Authors:
    Katarzyna Masłowska, Paweł Krzysztof Halik, Dagmara Tymecka, Aleksandra Misicka, Ewa Gniazdowska
    Academic press:
    Cancers (rok: 2021, tom: 13, strony: 1072), Wydawca: MDPI AG
    Status:
    Published
    DOI:
    10.3390/cancers13051072 - link to the publication
  4. Scandium-44 radiolabeled peptide and peptidomimetic conjugates targeting Neuropilin-1 co-receptor as potential tools for cancer diagnosis and anti-angiogenic therapy.
    Authors:
    Katarzyna Masłowska, Patrycja Redkiewicz, Paweł Krzysztof Halik, Ewa Witkowska, Dagmara Tymecka, Rafał Walczak, Jarosław Choiński, Aleksandra Misicka, Ewa Gniazdowska
    Academic press:
    Biomedicines (rok: 2023, tom: 11, strony: 564), Wydawca: MDPI AG
    Status:
    Published
    DOI:
    10.3390/biomedicines11020564 - link to the publication
  5. Structure-activity relationship studies and biological properties evaluation of peptidic NRP-1 ligands: Investigation of N-terminal cysteine importance
    Authors:
    Anna K. Puszko, Piotr Sosnowski, Olivier Hermine, Gerard Hopfgartner, Yves Lepelletier, Aleksandra Misicka
    Academic press:
    Bioorganic & Medicinal Chemistry (rok: 2023, tom: 94, strony: 117482), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmc.2023.117482 - link to the publication
  6. Urea-peptide hybrids as VEGF-A165/NRP-1 complex inhibitors with improved receptor affinity and biological properties
    Authors:
    Anna K. Puszko, Piotr Sosnowski, Rachel Rignault-Bricard, Olivier Hermine, Gérard Hopfgartner, Karolina Pułka-Ziach, Yves Lepelletier, Aleksandra Misicka
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 72), Wydawca: MDPI AG
    Status:
    Published
    DOI:
    10.3390/ijms22010072 - link to the publication
  7. The Role of VEGF Receptors as Molecular Target in NuclearMedicine for Cancer Diagnosis and Combination Therapy
    Authors:
    Katarzyna Masłowska, Paweł Krzysztof Halik, Dagmara Tymecka, Aleksandra Misicka, Ewa Gniazdowska
    Academic press:
    Cancers (rok: 2021, tom: 13, strony: 1072), Wydawca: MDPI AG
    Status:
    Published
    DOI:
    10.3390/cancers13051072 - link to the publication
  1. Search for Peptidomimetic Inhibitors of the VEGF-A165 / NRP-1 Complex with Modification of the C-Terminal Arginine
    Authors:
    Dagmara Tymecka, Patrycja Redkiewicz, Piotr F.J. Lipiński, Aleksandra Misicka
    Conference:
    Proceedings of the 36th European and the 12th International Peptide Symposium (rok: 2022, tom: 36th European and the 12th International Peptide Symposium, strony: 109-112), Wydawca: European Peptide Society
    Data:
    konferencja 28.08. - 2.09.2022
    Status:
    Published
    DOI:
    10.17952/36EPS.2022.109 - link to the publication

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