Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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New hybrid compounds derived from 2-(2,5-dioxopyrrolidin-1-yl)-propanamide in the search for substances effective in treatment of drug resistant epilepsy

2018/29/N/NZ7/01966

Keywords:

Hybrid compounds amino acid derivatives pyrrolidine-2,5-dione drug resistant epilepsy 6 Hz (44 mA) seizure test MAO-B inhibitors

Descriptors:

  • NZ7_14:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Michał Andrzej Abram 

Number of co-investigators in the project: 3

Call: PRELUDIUM 15 - announced on 2018-03-15

Amount awarded: 208 880 PLN

Project start date (Y-m-d): 2019-03-29

Project end date (Y-m-d): 2023-03-28

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (1)
  1. Development of Novel Alaninamide Derivatives with Anticonvulsant Activity and Favorable Safety Profiles in Animal Models
    Authors:
    Michał Abram, Marcin Jakubiec, Paulina Koczurkiewicz-Adamczyk, Agata Doroz-Płonka, Anna Rapacz, Krzysztof Kamiński
    Academic press:
    International Journal of Molecular Sciences (rok: 2024, tom: 25, strony: 24), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25189861 - link to the publication
  1. Hybrid compounds based on the pyrrolidine-2,5-dione scaffold as candidates for new wide spectrum anticonvulsant agents
    Authors:
    Michał Abram, Marcin Jakubiec, Anna Rapacz, Bartłomiej Szulczyk, Krzysztof Kamiński
    Conference:
    6th International Electronic Conference on Medicinal Chemistry (rok: 2020, ), Wydawca: MDPI
    Data:
    konferencja 2020.11.1-2020.11.30
    Status:
    Published
    DOI:
    link to the publication

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