Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Effects of proteasome inhibition on mitochondrial homeostasis.

2019/33/B/NZ5/00780

Keywords:

mitochondria mitochondrial diseases proteasome proteasome inhibitors mitochondrial peptides

Descriptors:

  • NZ5_003:
  • NZ5_007:
  • NZ3_002:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Agnieszka Małgorzata Chacińska 

Number of co-investigators in the project: 5

Call: OPUS 17 - announced on 2019-03-15

Amount awarded: 2 234 420 PLN

Project start date (Y-m-d): 2020-10-09

Project end date (Y-m-d): 2024-11-08

Project duration:: 49 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  1. Temporal alterations of the nascent proteome in response to mitochondrial stress
    Authors:
    Stępkowski, T. M., Linke, V., Stadnik, D., Zakrzewski, M., Zawada, A. E., Serwa, R. A., & Chacinska, A.
    Academic press:
    Cell reports (rok: 2024, tom: 43(10), strony: 46048), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.celrep.2024.114803 - link to the publication
  2. Monitoring and analysis of mitochondrial precursor protein aggregates in the cytosol
    Authors:
    Maruszczak, K. K., & Chacinska, A.
    Academic press:
    Methods in enzymology (rok: 2024, tom: 706, strony: 287–311), Wydawca: Academic Press
    Status:
    Published
    DOI:
    10.1016/bs.mie.2024.07.020 - link to the publication
  3. Defective mitochondrial import as a challenge for cellular protein homeostasis
    Authors:
    Maruszczak, K. K., Ayyamperumal, S., & Chacinska, A.
    Academic press:
    FEBS letters (rok: 2023, tom: 597, strony: 1555–1568), Wydawca: FEBS Press
    Status:
    Published
    DOI:
    10.1002/1873-3468.14677 - link to the publication
  4. Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction
    Authors:
    Kim, M., Serwa, R. A., Samluk, L., Suppanz, I., Kodroń, A., Stępkowski, T. M., Elancheliyan, P., Tsegaye, B., Oeljeklaus, S., Wasilewski, M., Warscheid, B., & Chacinska, A.
    Academic press:
    Nature Communications (rok: 2023, tom: 14, strony: 46045), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41467-023-39642-8 - link to the publication
  5. Mechanisms of stress management in mitochondrial protein import
    Authors:
    Mukhtar, M., Thakkur, K., Chacinska, A., & Bragoszewski, P.
    Academic press:
    Biochemical Society Transactions (rok: 2023, tom: 51, strony: 2117–2126), Wydawca: Portland Press
    Status:
    Published
    DOI:
    10.1042/BST20230377 - link to the publication
  6. Immunoproteasome-specific subunit alterations as a potential therapeutic target for mitochondriopathies.
    Authors:
    Kodroń, A., Kowalski, K., Marins Mussulini, B. H., Hazir, C., Borrero-Landazabal, M. A., Ngati, S., Wasilewski, M., & Chacinska, A.
    Academic press:
    Journal of molecular biology (rok: 2025, tom: 437, strony: 169229), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jmb.2025.169229 - link to the publication
  7. Methods to monitor mitochondrial disulfide bonds
    Authors:
    Mussulini, B. H. M., Wasilewski, M., & Chacinska, A.
    Academic press:
    Methods in enzymology (rok: 2024, tom: 706, strony: 125–158), Wydawca: Academic Press
    Status:
    Published
    DOI:
    10.1016/bs.mie.2024.07.039 - link to the publication

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