Development of a three-dimensional in vitro model for studying the mechanisms of

Development of a three-dimensional in vitro model for studying the mechanisms of immunostimulatory activity of PD-1/PD-L1 inhibitors

2019/35/N/NZ5/04435

Keywords

Descriptors

NZ1_007: Inżynieria komórkowa
NZ5_007: Leczenie chorób człowieka
NZ6_002: Immunologia kliniczna

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Jagielloński, Wydział Chemii

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

Justyna Natalia Kocik-Król

Number of co-investigators in the project: 2

Call

PRELUDIUM 18 – announced on 2019-09-16

Amount awarded: 140 000 PLN
Project start date: 2020-06-26
Project end date: 2023-06-25
Project duration: 36 months (the same as in the proposal)
Project status: Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (2)

Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein–Protein Interaction

Authors:
Damian Muszak, Ewa Surmiak, Jacek Plewka, Katarzyna Magiera-Mularz, Justyna Kocik-Król, Bogdan Musielak, Dominik Sala, Radosław Kitel, Małgorzata Stec, Kazimierz Węglarczyk, Maciej Siedlar, Alexander Dömling, Łukasz Skalniak, Tad A. Holak

Academic press:
Journal of Medicinal Chemistry (year: 2021, volume: 64, pages: 11614–11636), Publisher: ACS Publications

Status:
Published

DOI:
10.1021/acs.jmedchem.1c00957 – link to the publication
Human and mouse PD-L1: similar molecular structure, but different druggability profiles

Authors:
Katarzyna Magiera-Mularz, Justyna Kocik, Bogdan Musielak, Jacek Plewka, Dominik Sala, Monika Machula, Przemysław Grudnik, Małgorzata Hajduk, Marcin Czepiel, Maciej Siedlar, Tad A.Holak, Łukasz Skalniak

Academic press:
iScience (year: 2021, volume: 24, pages: 101960), Publisher: Cell Press

Status:
Published

DOI:
10.1016/j.isci.2020.101960 – link to the publication

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