Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Development of a three-dimensional in vitro model for studying the mechanisms of immunostimulatory activity of PD-1/PD-L1 inhibitors

2019/35/N/NZ5/04435

Keywords:

immunostimulants immune checkpoints immunotherapy

Descriptors:

  • NZ1_007:
  • NZ5_007:
  • NZ6_002:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński, Wydział Chemii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Justyna Natalia Kocik-Król 

Number of co-investigators in the project: 2

Call: PRELUDIUM 18 - announced on 2019-09-16

Amount awarded: 140 000 PLN

Project start date (Y-m-d): 2020-06-26

Project end date (Y-m-d): 2023-06-25

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein–Protein Interaction
    Authors:
    Damian Muszak, Ewa Surmiak, Jacek Plewka, Katarzyna Magiera-Mularz, Justyna Kocik-Król, Bogdan Musielak, Dominik Sala, Radosław Kitel, Małgorzata Stec, Kazimierz Węglarczyk, Maciej Siedlar, Alexander Dömling, Łukasz Skalniak, Tad A. Holak
    Academic press:
    Journal of Medicinal Chemistry (rok: 2021, tom: 64, strony: 11614–11636), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.1c00957 - link to the publication
  2. Human and mouse PD-L1: similar molecular structure, but different druggability profiles
    Authors:
    Katarzyna Magiera-Mularz, Justyna Kocik, Bogdan Musielak, Jacek Plewka, Dominik Sala, Monika Machula, Przemysław Grudnik, Małgorzata Hajduk, Marcin Czepiel, Maciej Siedlar, Tad A.Holak, Łukasz Skalniak
    Academic press:
    iScience (rok: 2021, tom: 24, strony: 101960), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.isci.2020.101960 - link to the publication

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