Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

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Molecular mechanisms, signal transduction and inhibition of PEBP1-15LOX protein complex triggering the ferroptotic cell death

2019/35/D/ST4/02203

Keywords:

Lipoxygenase ferroptosis cell death PUFA molecular dynamics docking inhibitors drug design asthma

Descriptors:

  • ST4_004:
  • ST4_009:
  • NZ2_010:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Fizyki, Astronomii i Informatyki Stosowanej

woj. kujawsko-pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Karolina Anna Mikulska-Rumińska 

Number of co-investigators in the project: 3

Call: SONATA 15 - announced on 2019-09-16

Amount awarded: 1 240 440 PLN

Project start date (Y-m-d): 2020-07-08

Project end date (Y-m-d): 2024-07-07

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (12)
  1. NO● Represses the Oxygenation of Arachidonoyl PE by 15LOX/PEBP1: Mechanism and Role in Ferroptosis
    Authors:
    Karolina Mikulska-Ruminska, Tamil S Anthonymuthu, Anastasia Levkina, Indira H Shrivastava, Alexandr A Kapralov, Hülya Bayır, Valerian E Kagan, Ivet Bahar
    Academic press:
    International journal of molecular sciences (rok: 2021, tom: 22, strony: 5253), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ijms22105253 - link to the publication
  2. Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis
    Authors:
    Tamil S Anthonymuthu, Yulia Y Tyurina, Wan-Yang Sun, Karolina Mikulska-Ruminska, Indira H Shrivastava, Vladimir A Tyurin, Fatma B Cinemre, Haider H Dar, Andrew P VanDemark, Theodore R Holman, Yoel Sadovsky, Brent R Stockwell, Rong-Rong He, Ivet Bahar, Hülya Bayır, Valerian E Kagan
    Academic press:
    Redox biology (rok: 2021, tom: 38, strony: 101744), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2020.101744 - link to the publication
  3. Strikingly High Activity of 15‐Lipoxygenase Towards Di‐Polyunsaturated Arachidonoyl/Adrenoyl‐Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death
    Authors:
    Svetlana N Samovich, Karolina Mikulska‐Ruminska, Haider H Dar, Yulia Y Tyurina, Vladimir A Tyurin, Austin B Souryavong, Alexander A Kapralov, Andrew A Amoscato, Ofer Beharier, S Ananth Karumanchi, Claudette M St Croix, Xin Yang, Theodore R Holman, Andrew P VanDemark, Yoel Sadovsky, Rama K Mallampalli, Sally E Wenzel, Wei Gu, Yuri L Bunimovich, Ivet Bahar, Valerian E Kagan, Hülya Bayir
    Academic press:
    Angewandte Chemie International Edition (rok: 2024, tom: 63, strony: e202314710), Wydawca: Wiley-VCH GmbH
    Status:
    Published
    DOI:
    10.1002/anie.202314710 - link to the publication
  4. Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis
    Authors:
    Tamil S Anthonymuthu, Yulia Y Tyurina, Wan-Yang Sun, Karolina Mikulska-Ruminska, Indira H Shrivastava, Vladimir A Tyurin, Fatma B Cinemre, Haider H Dar, Andrew P VanDemark, Theodore R Holman, Yoel Sadovsky, Brent R Stockwell, Rong-Rong He, Ivet Bahar, Hülya Bayır, Valerian E Kagan
    Academic press:
    Redox biology (rok: 2021, tom: 38, strony: 101744), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2020.101744 - link to the publication
  5. NO● Represses the Oxygenation of Arachidonoyl PE by 15LOX/PEBP1: Mechanism and Role in Ferroptosis
    Authors:
    Karolina Mikulska-Ruminska, Tamil S Anthonymuthu, Anastasia Levkina, Indira H Shrivastava, Alexandr A Kapralov, Hülya Bayır, Valerian E Kagan, Ivet Bahar
    Academic press:
    International journal of molecular sciences (rok: 2021, tom: 22, strony: 5253), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ijms22105253 - link to the publication
  6. Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators
    Authors:
    Haider H Dar, Karolina Mikulska-Ruminska, Yulia Y Tyurina, Diane K Luci, Adam Yasgar, Svetlana N Samovich, Alexander A Kapralov, Austin B Souryavong, Vladimir A Tyurin, Andrew A Amoscato, Michael W Epperly, Galina V Shurin, Melissa Standley, Theodore R Holman, Claudette M St. Croix, Simon C Watkins, Andrew P VanDemark, Sandeep Rana, Alexey V Zakharov, Anton Simeonov, Juan Marugan, Rama K Mallampalli, Sally E Wenzel, Joel S Greenberger, Ganesha Rai, Hülya Bayir, Ivet Bahar, Valerian E Kagan
    Academic press:
    Proceedings of the National Academy of Sciences (rok: 2023, tom: 120, strony: e2218896120), Wydawca: National Academy of Sciences
    Status:
    Published
    DOI:
    10.1073/pnas.221889612 - link to the publication
  7. Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome
    Authors:
    Valerian E Kagan, Yulia Y Tyurina, Karolina Mikulska-Ruminska, Deena Damschroder, Eduardo Vieira Neto, Alessia Lasorsa, Alexander A Kapralov, Vladimir A Tyurin, Andrew A Amoscato, Svetlana N Samovich, Austin B Souryavong, Haider H Dar, Abu Ramim, Zhuqing Liang, Pablo Lazcano, Jiajia Ji, Michael W Schmidtke, Kirill Kiselyov, Aybike Korkmaz, Georgy K Vladimirov, Margarita A Artyukhova, Pushpa Rampratap, Laura K Cole, Ammanamanchi Niyatie, Emma-Kate Baker, Jim Peterson, Grant M Hatch, Jeffrey Atkinson, Jerry Vockley, Bernhard Kühn, Robert Wessells, Patrick CA van der Wel, Ivet Bahar, Hülya Bayir, Miriam L Greenberg
    Academic press:
    Nature Metabolism (rok: 2023, tom: 5, strony: 2184-2205), Wydawca: Nature Publishing Group UK
    Status:
    Published
    DOI:
    10.1038/s42255-023-00926-4 - link to the publication
  8. Formation of protein adducts with Hydroperoxy-PE electrophilic cleavage products during ferroptosis
    Authors:
    AA Amoscato, T Anthonymuthu, O Kapralov, LJ Sparvero, IH Shrivastava, K Mikulska-Ruminska, VA Tyurin, AA Shvedova, YY Tyurina, I Bahar, S Wenzel, H Bayir, VE Kagan
    Academic press:
    Redox Biology (rok: 2023, tom: 63, strony: 102758), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2023.102758 - link to the publication
  9. Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis
    Authors:
    Tamil S Anthonymuthu, Yulia Y Tyurina, Wan-Yang Sun, Karolina Mikulska-Ruminska, Indira H Shrivastava, Vladimir A Tyurin, Fatma B Cinemre, Haider H Dar, Andrew P VanDemark, Theodore R Holman, Yoel Sadovsky, Brent R Stockwell, Rong-Rong He, Ivet Bahar, Hülya Bayır, Valerian E Kagan
    Academic press:
    Redox biology (rok: 2021, tom: 38, strony: 101744), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2020.101744 - link to the publication
  10. Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal
    Authors:
    Wan-Yang Sun, Vladimir A Tyurin, Karolina Mikulska-Ruminska, Indira H Shrivastava, Tamil S Anthonymuthu, Yu-Jia Zhai, Ming-Hai Pan, Hai-Biao Gong, Dan-Hua Lu, Jie Sun, Wen-Jun Duan, Sergey Korolev, Andrey Y Abramov, Plamena R Angelova, Ian Miller, Ofer Beharier, Gao-Wei Mao, Haider H Dar, Alexandr A Kapralov, Andrew A Amoscato, Teresa G Hastings, Timothy J Greenamyre, Charleen T Chu, Yoel Sadovsky, Ivet Bahar, Hülya Bayır, Yulia Y Tyurina, Rong-Rong He, Valerian E Kagan
    Academic press:
    Nature chemical biology (rok: 2021, tom: 17, strony: 465-476), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41589-020-00734-x - link to the publication
  11. NO● Represses the Oxygenation of Arachidonoyl PE by 15LOX/PEBP1: Mechanism and Role in Ferroptosis
    Authors:
    Karolina Mikulska-Ruminska, Tamil S Anthonymuthu, Anastasia Levkina, Indira H Shrivastava, Alexandr A Kapralov, Hülya Bayır, Valerian E Kagan, Ivet Bahar
    Academic press:
    International journal of molecular sciences (rok: 2021, tom: 22, strony: 5253), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ijms22105253 - link to the publication
  12. Membrane regulation of 15LOX-1/PEBP1 complex prompts the generation of ferroptotic signals, oxygenated PEs
    Authors:
    Thiliban Manivarma, Aleksandr A Kapralov, Svetlana N Samovich, Yulia Y Tyurina, Vladimir A Tyurin, Andrew P VanDemark, Wieslaw Nowak, Hülya Bayır, Ivet Bahar, Valerian E Kagan, Karolina Mikulska-Ruminska
    Academic press:
    Free Radical Biology and Medicine (rok: 2023, tom: 208, strony: 458-467), Wydawca: Pergamon
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2023.09.001 - link to the publication