Projects funded by the NCN

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117 projects found matching your search criteria :

  1. Investigation of a new therapeutic strategy to lower mutant protein in SCA3 / MJD

    Call: OPUS 21 , Panel: NZ2

    Principal investigator: dr hab. Maciej Figiel

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  2. Hybrid human SUMO proteins for selective detection and labelling of SENP proteases

    Call: OPUS 21 , Panel: ST4

    Principal investigator: dr Wioletta Rut

    Politechnika Wrocławska

  3. The role of neutrophil serine proteases in the regulation of function of the podocyte and glomerular filtration barrier.

    Call: OPUS 21 , Panel: NZ4

    Principal investigator: dr hab. Agnieszka Piwkowska

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  4. Living on the edge: evolutionary adaptation of substrate-recruiting subunits of the cullin-RING ubiquitin ligase complex...

    Call: PRELUDIUM 20 , Panel: NZ1

    Principal investigator: Natalia Szulc

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

  5. The study of adsorption mechanisms of N-benzenamino(boronphenyl)methylphosphonic acids on different metal surfaces

    Call: PRELUDIUM 2 , Panel: ST4

    Principal investigator: dr Natalia Piergies

    Uniwersytet Jagielloński, Wydział Chemii

  6. Identification of natural substrates and physiological partners of mitochondrial AtFtsH4 protease from Arabidopsis thali...

    Call: PRELUDIUM 2 , Panel: NZ2

    Principal investigator: dr Elwira Smakowska

    Uniwersytet Wrocławski, Wydział Biotechnologii

  7. Assessment of the functions of granzyme A in neutrophils using induced pluripotent stem cells

    Call: OPUS 20 , Panel: NZ1

    Principal investigator: dr Paulina Kasperkiewicz-Wasilewska

    Politechnika Wrocławska

  8. The role of extracellular proteases – yapsins – in gaining pathogenic advantage by Candida glabrata in the host organism...

    Call: SONATA 16 , Panel: NZ6

    Principal investigator: dr Dorota Satała

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  9. Dissecting cancer activome to develop new generation of antibody-drug conjugates

    Call: OPUS 20 (LAP) , Panel: NZ5

    Principal investigator: dr hab. Marcin Poręba

    Politechnika Wrocławska

  10. Defining the interplay between SLPI and the IL-1 family cytokines in the immune response

    Call: SONATA 16 , Panel: NZ6

    Principal investigator: dr Ewa Oleszycka

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  11. Neutrophils heterogeneity based on serine proteases

    Call: SONATA BIS 10 , Panel: NZ3

    Principal investigator: dr Paulina Kasperkiewicz-Wasilewska

    Politechnika Wrocławska

  12. Role of cereal leaf beetle – associated bacteria in the adaptation of their insect host to the insecticides and protease...

    Call: PRELUDIUM 19 , Panel: NZ9

    Principal investigator: Beata Wielkopolan

    Instytut Ochrony Roślin - Państwowy Instytut Badawczy

  13. Molecular mechanism underlying the anti-inflammatory action of CB2 receptor agonists in microglia: participation of the ...

    Call: OPUS 19 , Panel: NZ7

    Principal investigator: dr Natalia Małek-Chudzik

    Politechnika Wrocławska

  14. Exploring the allosteric regulation of the SARS CoV-2 hydrolases using methyl-TROSY NMR spectroscopy - in search of nove...

    Call: OPUS 19 , Panel: ST4

    Principal investigator: prof. Wiktor Koźmiński

    Uniwersytet Warszawski, Wydział Chemii

  15. Participation of cellular proteins in the inhibition of antigen presentation dependent on UL49.5 protein of bovine herpe...

    Call: ETIUDA 8 , Panel: NZ3

    Principal investigator: Magda Wąchalska

    Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

  16. Host sex effect on immunity and protection after oral immunization with Fasciola hepatica cysteine protease and the para...

    Call: OPUS 18 , Panel: NZ6

    Principal investigator: dr hab. Małgorzata Kęsik-Brodacka

    Sieć Badawcza ŁUKASIEWICZ - Instytut Biotechnologii i Antybiotyków

  17. Novel analogs of human cathelicidin (LL-37) with enhanced resistant to enzymatic degradation. Design chemical synthesis ...

    Call: PRELUDIUM BIS 1 , Panel: ST4

    Principal investigator: prof. Adam Lesner

    Uniwersytet Gdański, Wydział Chemii

  18. Molecular mechanisms modulating the function of UCH-L1 deubiquitinase in human mitochondria

    Call: OPUS 18 , Panel: NZ3

    Principal investigator: prof. Agnieszka Chacińska

    Fundacja ReMedy+

  19. Tannerella forsythia: regulation of intra- and extracellular proteolytic activity in pathogenicity mechanism.

    Call: PRELUDIUM 2 , Panel: NZ1

    Principal investigator: Mirosław Książek

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  20. The KLIKK proteases of human pathogen Tannerella forsythia: putative virulence factors with unique biochemical and struc...

    Call: OPUS 18 , Panel: NZ1

    Principal investigator: dr Mirosław Książek

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  21. SufA bacterial protease inhibitors as potential diagnostic tools and antibacterial agents.

    Call: SONATA 15 , Panel: NZ7

    Principal investigator: dr Ewa Burchacka

    Politechnika Wrocławska

  22. Hijacking the ubiquitin-proteasome system by the UL49.5 protein of bovine herpesvirus 1 as an immune evasion strategy – ...

    Call: PRELUDIUM 18 , Panel: NZ6

    Principal investigator: Magda Wąchalska

    Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

  23. Design and synthesis of proteolytically stable and cell permeable activators of human 20S proteasome and assessing their...

    Call: PRELUDIUM BIS 1 , Panel: NZ7

    Principal investigator: dr hab. Elżbieta Jankowska

    Uniwersytet Gdański, Wydział Chemii

  24. Inhibitors of serine proteases as regulators of dendritic cell function.

    Call: MAESTRO 1 , Panel: NZ5

    Principal investigator: prof. Joanna Cichy

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  25. Cellular adaptation to cold.

    Call: GRIEG 1 , Panel: NZ3

    Principal investigator: dr Wojciech Pokrzywa

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

  26. Preventing the accumulation of cytotoxic oligomers, that are causative agents of neurodegenerative diseases and Type 2 D...

    Call: OPUS 17 , Panel: NZ7

    Principal investigator: dr hab. Elżbieta Jankowska

    Uniwersytet Gdański, Wydział Chemii

  27. Effects of proteasome inhibition on mitochondrial homeostasis.

    Call: OPUS 17 , Panel: NZ5

    Principal investigator: prof. Agnieszka Chacińska

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  28. Analysis of SWI/SNF complexes in Arabidopsis and of their activity's regulation through 26S proteasome with special cons...

    Call: PRELUDIUM 1 , Panel: NZ1

    Principal investigator: Anna Rolicka

    Uniwersytet Warszawski, Wydział Biologii

  29. Epigenetic regulation of pro-epileptic protease Matrix Metalloproteinase-9 expression in the hippocampus during epilepto...

    Call: OPUS 1 , Panel: NZ2

    Principal investigator: dr hab. Marcin Rylski

    CENTRUM MEDYCZNE KSZTAŁCENIA PODYPLOMOWEGO

  30. Doubly knotted proteins - frontiers of topological complexity of proteins

    Call: OPUS 16 , Panel: NZ1

    Principal investigator: dr hab. Joanna Sułkowska

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  31. Molecular basics of type II transmembrane serine proteases (TTSPs)-mediated activation of influenza viruses

    Call: BEETHOVEN LIFE 1 , Panel: NZ1

    Principal investigator: dr Paweł Zmora

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  32. Characterization of two novel proteases from the human periodontopathogen Tannerella forsythia

    Call: PRELUDIUM 16 , Panel: NZ1

    Principal investigator: Irena Waligórska

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  33. Mechanisms of host-pathogen interaction in the immune response of Galleria mellonella after infection with entomopathoge...

    Call: OPUS 1 , Panel: NZ6

    Principal investigator: dr hab. Iwona Wojda

    Uniwersytet Marii Curie-Skłodowskiej, Wydział Biologii i Biotechnologii

  34. Dissecting the proteolytic fingerprint of breast cancer tissues using mass cytometry for personalized oncology.

    Call: SONATA 14 , Panel: NZ5

    Principal investigator: dr Marcin Poręba

    Politechnika Wrocławska

  35. Application of lanthanides in activity-based probes for the simultaneous detection of proteolytic enzymes.

    Call: HARMONIA 10 , Panel: ST5

    Principal investigator: prof. Marcin Drąg

    Politechnika Wrocławska

  36. CP protease of the O'nyong-nyong virus: substrate profiling, design and synthesis of inhibitors and activity-based probe...

    Call: OPUS 15 , Panel: NZ6

    Principal investigator: dr hab. Marcin Sieńczyk

    Politechnika Wrocławska

  37. Association of TXNDC5 and calreticulin with decreased ER stress, allowing resistant multiple myeloma cells to by-pass pr...

    Call: PRELUDIUM 15 , Panel: NZ5

    Principal investigator: Tadeusz Kubicki

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski

  38. Functional and structural interplay between two mitochondrial inner membrane proteases, AtFTSH4 and AtOMA1, in Arabidops...

    Call: OPUS 14 , Panel: NZ2

    Principal investigator: prof. Hanna Jańska

    Uniwersytet Wrocławski, Wydział Biotechnologii

  39. Cellular proteases during coronaviral infection

    Call: OPUS 14 , Panel: NZ6

    Principal investigator: dr hab. Krzysztof Pyrć

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  40. Novel inhibitors of herpes virus protease

    Call: PRELUDIUM 14 , Panel: NZ6

    Principal investigator: Magdalena Pachota

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  41. Role of proteasome in the regulation of Gli protein activity by the Hedgehog pathway

    Call: OPUS 14 , Panel: NZ3

    Principal investigator: dr hab. Paweł Niewiadomski

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  42. Toward understanding allosteric regulation of the proteasome activity

    Call: OPUS 1 , Panel: ST5

    Principal investigator: dr hab. Elżbieta Jankowska

    Uniwersytet Gdański, Wydział Chemii

  43. Determination of arginase-1 as a potential drug target in the treatment of multiple myeloma and in reducing proteasome i...

    Call: OPUS 13 , Panel: NZ6

    Principal investigator: prof. Jakub Gołąb

    Warszawski Uniwersytet Medyczny, Wydział Lekarski

  44. Proteomic analysis of myeloma plasma cells to determine proteins and pathways involved in acquired resistance to proteas...

    Call: OPUS 13 , Panel: NZ5

    Principal investigator: dr hab. Dominik Dytfeld

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski

  45. Identification and therapeutic use of proteasome machinery targets in human cancer

    Call: OPUS 13 , Panel: NZ5

    Principal investigator: dr Dawid Walerych

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  46. The development of classic and aggregation- induced emission activity- based probes for human caspases.

    Call: PRELUDIUM 13 , Panel: ST5

    Principal investigator: Katarzyna Groborz

    Politechnika Wrocławska

  47. An integrated screening platform for determination of human proteasomes extended substrate specificity

    Call: OPUS 13 , Panel: ST5

    Principal investigator: prof. Marcin Drąg

    Politechnika Wrocławska

  48. SLPI-dependent cutaneous antimicrobial and antiviral immunity.

    Call: OPUS 13 , Panel: NZ6

    Principal investigator: prof. Joanna Cichy

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  49. The structural and functional characterization of Tpr, calpain-like peptidase and important virulence factor of Porphyro...

    Call: PRELUDIUM 13 , Panel: NZ1

    Principal investigator: dr Dominika Staniec

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  50. Allosteric inhibitors of proteasome - optimization of the structure of PR39 analogs in order to achieve greater efficien...

    Call: PRELUDIUM 12 , Panel: ST5

    Principal investigator: Małgorzata Giżyńska

    Uniwersytet Gdański, Wydział Chemii

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