Tannerella forsythia: regulation of intra- and extracellular proteolytic activity in pathogenicity mechanism.
2011/03/N/NZ1/00586
Keywords
Descriptors
- NZ1_2: Biochemia
- NZ1_1: Biologia molekularna
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii
Voivodeship: małopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
PRELUDIUM 2 – announced on 2011-09-15
- Amount awarded
- 192 400 PLN
- Project start date
- 2012-09-17
- Project end date
- 2014-09-16
- Project duration
- 24 months (the same as in the proposal)
- Project status
- Project settled
Information in the final report
Publication in academic press/journals (4)
-
Mirolase, a novel subtilisin-like serine protease from the periodontopathogen Tannerella forsythia.
- Authors:
- Ksiazek M, Karim AY, Bryzek D, Enghild JJ, Thøgersen IB, Koziel J, Potempa J
- Academic press:
- Biological Chemistry (year: 2015, volume: 396, pages: 261-75), Publisher: De Gruyter
- Status:
- Published
- DOI:
- 10.1515/hsz-2014-0256 – link to the publication
-
Miropin, a novel bacterial serpin from the periodontopathogen Tannerella forsythia, inhibits a broad range of proteases by using different peptide bonds within the reactive center loop.
- Authors:
- Ksiazek M, Mizgalska D, Enghild JJ, Scavenius C, Thogersen IB, Potempa J
- Academic press:
- The Journal of Biological Chemistry (year: 2015, volume: 290, pages: 658-70), Publisher: American Society of Biochemistry and Molecular Biology
- Status:
- Published
- DOI:
- 10.1074/jbc.M114.601716 – link to the publication
-
Structure of the catalytic domain of the Tannerella forsythia matrix metallopeptidase karilysin in complex with a tetrapeptidic inhibitor
- Authors:
- Guevara T, Ksiazek M, Skottrup PD, Cerdà-Costa N, Trillo-Muyo S, de Diego I, Riise E, Potempa J, Gomis-Rüth FX
- Academic press:
- Acta Crystallogr Sect F Struct Biol Cryst Commun. (year: 2013, volume: 69, pages: 472-6), Publisher: International Union of Crystallography
- Status:
- Published
- DOI:
- 10.1107/S1744309113007392 – link to the publication
-
Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases.
- Authors:
- Veillard F, Sztukowska M, Mizgalska D, Ksiazek M, Houston J, Potempa B, Enghild JJ, Thogersen IB, Gomis-Rüth FX, Nguyen KA, Potempa J.
- Academic press:
- BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (year: 2013, volume: 1830, pages: 4218-4228), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.bbagen.2013.04.005 – link to the publication