Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Optimization of the substrates structure to study deubiquitinating enzymes using methods of combinatorial chemistry

2015/17/N/ST5/03072

Keywords:

proteases deubiquitinating enzymes unnatural amino acids combinatorial fluorogenic substrates library

Descriptors:

  • ST5_16:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Wrocławska, Wydział Chemiczny, Zakład Chemii Bioorganicznej

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Wioletta Rut 

Number of co-investigators in the project: 2

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 99 996 PLN

Project start date (Y-m-d): 2016-03-16

Project end date (Y-m-d): 2018-03-15

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer osobisty (laptop) (3 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (1)
  1. Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design
    Authors:
    Wioletta Rut, Zongyang Lv, Mikolaj Zmudzinski, Stephanie Patchett, Digant Nayak, Scott J. Snipas, Farid El Oualid, Tony T. Huang, Miklos Bekes, Marcin Drag, Shaun K. Olsen
    Academic press:
    Science Advances (rok: 2020, tom: 6, strony: 45304), Wydawca: American Association for the Advancement of Science
    Status:
    Published
    DOI:
    10.1126/sciadv.abd4596 - link to the publication
  2. Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
    Authors:
    Rut W., Zmudzinski M., Snipas S.S., Bekes M., Huang T.T., Drag M.
    Academic press:
    Chemical Science (rok: 2020, tom: 11, strony: 6058-6069), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d0sc01347a - link to the publication
  1. HyCoSuL approach in determining Deubiquitinating enzymes substrate specificity
    Authors:
    W. Rut, M. Bekes, T.T. Huang, M. Drąg
    Conference:
    XVth International Symposium on Proteases, Inhibitors and Biological Control (rok: 2016, ), Wydawca: Boris Turk
    Data:
    konferencja 17-21.09.2016
    Status:
    Published

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