Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Zika virus NS3 protease

2016/21/B/NZ6/01307

Keywords:

zika virus inhibitor protease

Descriptors:

  • NZ6_5: Virology
  • ST4_3: Molecular architecture and structure
  • NZ3_1: Cell biology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Krzysztof Pyrć 

Number of co-investigators in the project: 5

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 853 560 PLN

Project start date (Y-m-d): 2017-05-16

Project end date (Y-m-d): 2022-05-15

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Notebook.
  2. Oprogramowanie do analizy szlaków komórkowych (60 000 PLN)
  3. Laser do mikroskopu konfokalnego (42 000 PLN)
  4. Oprogramowanie do integracji danych z systemów MALDI-TOF-TOF oraz ESI-ITD oraz analizy bioinformatycznej (100 000 PLN)
  5. Sprzęt obliczeniowy (12 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  1. Zika virus: mapping and reprogramming the entry
    Authors:
    Katarzyna Owczarek, Yuliya Chykunova, Christian Jassoy, Beata Maksym, Zenon Rajfur, Krzysztof Pyrc
    Academic press:
    Cell Communication and Signaling (rok: 2019, tom: 17, strony: 41), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12964-019-0349-z - link to the publication
  2. MASS SPECTROMETRY IN VIROLOGICAL SCIENCES.
    Authors:
    Milewska A, Ner-Kluza J, Dabrowska A, Bodzon-Kulakowska A, Pyrc K, Suder P.
    Academic press:
    Mass spectrometry reviews (rok: 2019, tom: --, strony: --), Wydawca: New York : Wiley,
    Status:
    Published
    DOI:
    10.1002/mas.21617 - link to the publication
  3. Self-Organized Nanoparticles of Random and Block Copolymers of Sodium 2-(Acrylamido)-2-methyl-1-propanesulfonate and Sodium 11-(Acrylamido)undecanoate as Safe and Effective Zika Virus Inhibitors
    Authors:
    Botwina P, Obłoza M, Zatorska-Płachta M, Kamiński K, Mizusaki M, Yusa SI, Szczubiałka K, Pyrc K, Nowakowska M.
    Academic press:
    Pharmaceutics (rok: 2022, tom: 14(2), strony: 309), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics14020309 - link to the publication
  4. In Vitro Inhibition of Zika Virus Replication with Poly(Sodium 4-Styrenesulfonate).
    Authors:
    Botwina P, Obłoza M, Szczepański A, Szczubiałka K, Nowakowska M, Pyrć K.
    Academic press:
    Viruses-Basel (rok: 2020, tom: 12, strony: 926), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v12090926 - link to the publication
  5. One Step Beyond: Design of Substrates Spanning Primed Positions of Zika Virus NS2B-NS3 Protease.
    Authors:
    Gruba N, Martinez JIR, Grzywa R, Wysocka M, Skoreński M, Dabrowska A, Łęcka M, Suder P, Sieńczyk M, Pyrc K, Lesner A.
    Academic press:
    ACS medicinal chemistry letters. (rok: 2018, tom: 10, strony: 1025-1029), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acsmedchemlett.8b00316 - link to the publication
  6. Mass Spectrometry versus Conventional Techniques of Protein Detection: Zika Virus NS3 Protease Activity towards Cellular Proteins
    Authors:
    Dabrowska A, Milewska A, Ner-Kluza J, Suder P, Pyrc K.
    Academic press:
    Molecules (rok: 2021, tom: 26(12), strony: 3732), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26123732 - link to the publication
  7. Mouse single oocyte imaging by MALDI-TOF MS for lipids.
    Authors:
    Bodzon-Kulakowska A., Arena R., Mielczarek P., Hartman K., Kozol P., Gibula-Tarlowska E., Wrobel T.P., Gasior L., Polanski Z., Ptak G.E., Suder P.
    Academic press:
    Cytotechnology (rok: 2020, tom: 3, strony: 455-468), Wydawca: SPRINGER
    Status:
    Published
    DOI:
    10.1007/s10616-020-00393-9 - link to the publication
  8. Phosphonate inhibitors of West Nile virus NS2B/NS3 protease.
    Authors:
    Skoreński M, Milewska A, Pyrć K, Sieńczyk M, Oleksyszyn J.
    Academic press:
    Journal of enzyme inhibition and medicinal chemistry. (rok: 2019, tom: 34, strony: 45518), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/14756366.2018.1506772 - link to the publication

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