Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Roles of Candida albicans adhesins and secreted proteases in neutrophil extracellular trap (NET) formation - traitors or allies of host in candidial infection?

2012/05/B/NZ1/00003

Keywords:

Candida albicans neutrophil extracellular trap adhesins protease infection candidiasis

Descriptors:

  • NZ1_10: Microbiology
  • NZ1_2: Biochemistry
  • NZ6_7: Mycology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

UNIWERSYTET JAGIELLOŃSKI, Wydział Biochemii Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Maria Rąpała-Kozik 

Number of co-investigators in the project: 7

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 684 000 PLN

Project start date (Y-m-d): 2013-02-14

Project end date (Y-m-d): 2016-06-13

Project duration:: 40 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Automatyczny licznik komórek (15 000 PLN)
  2. Czytnik mikropłytek z detekcją fluorescencyjną (135 000 PLN)
  3. Inkubator CO2 do hodowli komórkowych (40 000 PLN)
  4. komora laminarna do prac z komórkami.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (7)
  • Book publications / chapters in book publications (1)
  1. Selected mucolytic, anti-inflammatory and cardiovascular drugs change the ability of neutrophils to form extracellular traps (NETs).
    Authors:
    Zawrotniak M, Kozik A, Rapala-Kozik M.
    Academic press:
    Acta Biochim. Pol. (rok: 2015, tom: 62(3), strony: 465-73), Wydawca: Polish Biochemical Society and of the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.18388/abp.2015_1055. - link to the publication
  2. Aspartic proteases and major cell wall components in Candida albicans trigger the release of Neutrophil Extracellular Traps.
    Authors:
    Zawrotniak M., Bochenska O., Karkowska-Kuleta J., Seweryn-Ożóg K., Aoki W., Ueda M., Kozik A. Rapala-Kozik M.
    Academic press:
    Frontiers in Cellular and Infection Microbiology (rok: 2017, tom: 7, strony: article 414), Wydawca: Frontiers,open-access academic publisher
    Status:
    Published
    DOI:
    10.3389/fcimb.2017.00414 - link to the publication
  3. Inactivation of alpha1-proteinase inhibitor by Candida albicans aspartic proteases favors the epithelial and endothelial cell colonization in the presence of neutrophil extracellular traps
    Authors:
    Gogol M., Ostrowska D., Klaga K.,Bochenska O., Wolak N., Aoki W., Ueda M., Kozik A., Rapala-Kozik M.
    Academic press:
    Acta Biochim. Pol. (rok: 2016, tom: 63, strony: 167-175), Wydawca: Polish Biochemical Society and of the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.18388/abp.2015_1163 - link to the publication
  4. Inactivation of the antifungal and immunomodulatory properties of human cathelicidin LL-37 by aspartic proteases produced by the pathogenic yeast Candida albicans
    Authors:
    Maria Rapala-Kozik, Oliwia Bochenska, Marcin Zawrotniak, Natalia Wolak, Grzegorz Trebacz, Mariusz Gogol, Dominika Ostrowska, Wataru Aoki, Mitsuyoshi Ueda, and Andrzej Kozik.
    Academic press:
    Infection and Immunity (IAI) (rok: 2015, tom: 83, strony: 2518-2530), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/IAI.00023-15 - link to the publication
  5. Neutrophil extracellular traps (NETs) - formation and implications.
    Authors:
    Zawrotniak M, Rapala-Kozik M.
    Academic press:
    Acta Biochimica Polonica (rok: 2013, tom: 60(3), strony: 277-84), Wydawca: Polish Biochemical Society and of the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Status:
    Published
    DOI:
    brak - link to the publication
  1. Identification of Candida albicans surface proteins involved in binding of human cathelicidn LL-37 and changes in LL-37 antifungal properties during its citrullination that can occur in Neutrophil Extracellular Traps (NETs)
    Authors:
    M. Rapala-Kozik, K. Seweryn, M. Gogol, D. Zajac, J. Karkowska-Kuleta, O. Bochenska, J. Koziel, J. Potempa, A. Kozik;
    Conference:
    13th ASM Conference on Candida and Candidiasis (rok: 2016, ), Wydawca: ASM
    Data:
    konferencja 13-17 kwietnia
    Status:
    Published
  2. Interaction of Candida albicans cell wall proteins with components of neutrophil extracellular traps formed during the host response to candidal infections
    Authors:
    Rapala-Kozik M., Seweryn K., Kluza A., Zawrotniak M, Klaga K., Kozik A.
    Conference:
    19 th Congress of the International Society for Human and Animal Mycology (rok: 2015, ), Wydawca: ISHAM
    Data:
    konferencja 4-8 May
    Status:
    Published
  3. A possible involvement of secreted aspartic proteases of Candida albicans in the propagation of inflamation during candidiasis
    Authors:
    Gogól M., Kozik A., Rapala-Kozik M.
    Conference:
    6th International Weigl Conference on Microbiology (rok: 2015, ), Wydawca: Polish Biochemical Society
    Data:
    konferencja 8-10 July
    Status:
    Published
  4. Altered production of reactive oxygen species and release of extracellular traps by neutrophils under the influence of selected mucolytic, anti-inflammatory, anti-histamine and cardiovascular drugs
    Authors:
    M. Zawrotniak, A. Kozik, M. Rapala-Kozik
    Conference:
    FEBS-EMBO Conference, Paris 2014 (rok: 2014, ), Wydawca: Federation of European Biochemical Societies, FEBS Journal 281 (Suppl. 1)
    Data:
    konferencja 30.08-4.09
    Status:
    Published
    DOI:
    link to the publication
  5. Degradation of proteinaceous components of neutrophil extracellular traps by aspartic proteases secreted by pathogenic yeasts, Candida albicans
    Authors:
    M. Gogol, O. Bochenska, N. Wolak, W. Aoki, M. Ueda, A. Kozik, M. Rapala-Kozik
    Conference:
    FEBS-EMBO Conference, Paris 2014 (rok: 2014, ), Wydawca: Federation of European Biochemical Societies, FEBS Journal 281 (Suppl. 1)
    Data:
    konferencja 30.08-4.09
    Status:
    Published
    DOI:
    link to the publication
  6. The neutrophil extracellular traps (NETs) influence the susceptibility of epithelial and endothelial cells to fungal infections
    Authors:
    Ostrowska D., Klaga K., Rapala-Kozik M.
    Conference:
    "Regulatory myeloid cells (MRC) in health and disease", (rok: 2015, ), Wydawca: Mye-EUNITER
    Data:
    konferencja Krakow, 14-16 Sept.
    Status:
    Published
  7. Virulence factors of pathogenic yeast Candida albicans that affect the efficiency of fungal cell killing by extracellular traps .
    Authors:
    Rapala - Kozik , M., Zawrotniak , M., Aoki , W., Ueda , M., Gogol , M., Seweryn , K., Wolak , N., Bochenska , O., Karkowska - Kuleta , J., Kluza , A., Kozik , A
    Conference:
    International Symposium NEUTROPHIL 2014 (rok: 2014, ), Wydawca: Society for Leukocyte Biology (SLB).
    Data:
    konferencja 31.05-3.06
    Status:
    Published
    DOI:
    link to the publication
  1. Neutrophil Extracellular Traps in Infectious Human Diseases
    Authors:
    Zawrotniak M., Kozik A., Rapala-Kozik M.
    Book:
    Role of Neutrophils in Disease Pathogenesis (rok: 2017, tom: 45450, strony: 45376), Wydawca: INTECH, Medicine
    Status:
    Published
    DOI:
    link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy