Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Extracellular proteolytic activity of human epithelium - role in the modulation of signal transduction.

2013/08/W/NZ1/00696

Keywords:

protease signalling imaging substrate specificity inhibitor

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry
  • NZ1_4: Structural biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jan Potempa 

Number of co-investigators in the project: 17

Call: SYMFONIA 1

Amount awarded: 6 995 680 PLN

Project start date (Y-m-d): 2013-12-09

Project end date (Y-m-d): 2018-06-08

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (6)
  1. Gingipains of Porphyromonas gingivalis Affect the Stability and Function of Serine Protease Inhibitor of Kazal-type 6 (SPINK6), a Tissue Inhibitor of Human Kallikreins.
    Authors:
    Plaza K, Kalinska M, Bochenska O, Meyer-Hoffert U, Wu Z, Fischer J, Falkowski K, Sasiadek L, Bielecka E, Potempa B, Kozik A, Potempa J, Kantyka T
    Academic press:
    Journal of Biological Chemistry (rok: 2016, tom: 36, strony: 18753-64), Wydawca: American Society of Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1074/jbc.M116.722942 - link to the publication
  2. Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase
    Authors:
    Theodoros Goulas Danuta Mizgalska Irene Garcia-Ferrer Tomasz Kantyka Tibisay GuevaraBorys Szmigielski Aneta Sroka Claudia Millán Isabel Usón Florian Veillard Barbara Potempa Piotr Mydel Maria Solà Jan Potempa F. Xavier Gomis-Rüth
    Academic press:
    Scientific Reports (rok: 2015, tom: 5, strony: 11969 (s. 1-17)), Wydawca: Nature Publishing
    Status:
    Published
    DOI:
    10.1038/srep11969 - link to the publication
  3. Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity
    Authors:
    Natalia Gruba, Ewa Bielecka, Magdalena Wysocka, Anna Wojtysiak, Magdalena Brzezińska-Bodal, Kamila Sychowska, Magdalena Kalińska, Małgorzata Magoch, Aleksandra Pęcak, Katherine Falkowski, Magdalena Wiśniewska, Laura Sąsiadek, Karolina Płaza, Eileen Kroll, Anastasija Pejkovska, Maren Rehders, Klaudia Brix, Grzegorz Dubin, Tomasz Kantyka, Jan Potempa, Adam Lesner
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20(7), strony: 1557), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20071557 - link to the publication
  4. Kallikrein 13: a new player in coronaviral infections
    Authors:
    Aleksandra Milewska, Katherine Falkowski, Magdalena Kalinska, Ewa Bielecka, Antonina Naskalska, Pawel Mak, Adam Lesner, Marek Ochman, Maciej Urlik, Elftherios Diamandis, Ioannis Prassas, Jan Potempa, Tomasz Kantyka, Krzysztof Pyrc
    Academic press:
    Science Signaling (rok: 2020, tom: 13, strony: b.d), Wydawca: Science
    Status:
    Published
    DOI:
    10.1126/scisignal.aba9902 - link to the publication
  5. Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)—A CleavEx Based Analysis
    Authors:
    Katherine Falkowski, Ewa Bielecka, Ida B. Thøgersen, Oliwia Bocheńska, Karolina Płaza, Magdalena Kalińska, Laura Sąsiadek, Małgorzata Magoch, Aleksandra Pęcak, Magdalena Wiśniewska, Natalia Gruba, Magdalena Wysocka, Anna Wojtysiak, Magdalena Brzezińska-Bodal, Kamila Sychowska, Anastasija Pejkovska, Maren Rehders, Georgina Butler, Christopher M Overall, Klaudia Brix, Grzegorz Dubin, Adam Lesner, Andrzej Kozik, Jan J. Enghild, Jan Potempa, Tomasz Kantyka
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21(12), strony: 4383), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21124383 - link to the publication
  6. Kallikreins - The melting pot of activity and function
    Authors:
    Magdalena Kalinska Ulf Meyer-Hoffert Tomasz Kantyka Jan Potempa
    Academic press:
    Biochimie (rok: 2016, tom: 122, strony: 270-82), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biochi.2015.09.023 - link to the publication

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